Increased orbitofrontal cortex activation associated with “pro-obsessive” antipsychotic treatment in patients with schizophrenia

Antipsychotics-associated obsessive-compulsive symptoms: individualized treatments and clinical benefits of memantine: a case report

“…Interestingly, in research of pathology on SGAs-induced OCS in schizophrenia, a stronger brain activation was observed by functional magnetic resonance imaging in the OFC during a response inhibition task in patients taking SGAs with a prominent anti-serotoninergic profile compared to patients receiving SGAs with a prominent dopaminergic blockade, correlated with more severe OCS. A correlation was also observed between OFC activation and clinical severity of obsessions reflecting in the YBOCS (13). In primary OCD, genetic researchers have found significant associations with glutamate related genes including glutamate transporter (SLC1A1) gene (14) which has also been implicated in SGAs-induced OCS.…”

Effects of aripiprazole versus risperidone on brain activation during planning and social-emotional evaluation in schizophrenia: A single-blind randomized exploratory study

“…Risperidone shows opposite results. Previous (longitudinal) patient treatment studies did not report significant prefrontal changes after aripiprazole treatment (Schlagenhauf et al, 2010;Sarpal et al, 2015;Ikuta et al, 2014;Schirmbeck et al, 2015). Moreover, single dose studies in healthy subjects show decreased prefrontal activation after aripiprazole treatment (Kim et al, 2013;Kim et al, 2008;Handley et al, 2013), but also preserved prefrontal and parietal brain activation (Goozee et al, 2015) or non-significantly increased frontal and temporal activation (Bolstad et al, 2015).…”

Schizo-Obsessive Disorder: A Brief Report of Neuroimaging Findings

“…While OCD patients were indistinguishable from HC, a similarly reduced lateralization in the inferior frontal gyrus and diminished interhemispheric functional connectivity were noted in the schizo-obsessive and SCZ groups, reporting no differences between schizo-obsessive and SCZ patients. Another recent fMRI study, conducted by Schirmbeck et al [16], utilized response inhibition and N-back working memory paradigms to evaluate the effects of second-generation antipsychotics on the neural mechanisms related to OCS in SCZ patients. The investigators stratified patients in two groups: group I, SCZ patients (n = 21) treated with clozapine or olanzapine, and group II, SCZ patients (n = 19) treated with amisulpride or aripiprazole.…”

“…One [9] of the above-mentioned original research articles was discarded as unrelated to the topic. In addition to our PubMed search, another 4 relevant neuroimaging studies in schizo-obsessive disorder (all original research reports) were also included in this report, based on our knowledge of the subject [16,17,18,19]. All articles were written in the English language.…”