Increased odds ratio for erectile dysfunction in COVID-19 patients

Katz, Joseph; Yue, Sijia; Xue, Wei; Gao, Hanzhi

doi:10.1007/s40618-021-01717-y

Cited by 32 publications

(30 citation statements)

References 36 publications

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“…This first post COVID-19 screening of sexual functioning may be an important point to remark, as it may represent a long-term effect of drugs and/or COVID-19 related distress and may impact on both reproductive health and quality of life [ 45 – 49 ]. Recent reports highlighted the association of SARS-CoV-2 infection and increased prevalence of ED [ 50 , 51 ]. Sivitrepe et al investigated the presence of ED after three months of hospital discharge for COVID-19 detecting a further worsening of IIEF scores compared to the scores at hospital admission, linking this worsening to IL-6 levels [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Male reproductive health after 3 months from SARS-CoV-2 infection: a multicentric study

Paoli

Pallotti

Anzuini

et al. 2022

J Endocrinol Invest

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Purpose While SARS-CoV-2 infection appears not to be clinically evident in the testes, indirect inflammatory effects and fever may impair testicular function. To date, few long-term data of semen parameters impairment after recovery and comprehensive andrological evaluation of recovered patients has been published. The purpose of this study was to investigate whether SARS-CoV-2 infection affect male reproductive health. Methods Eighty patients were recruited three months after COVID-19 recovery. They performed physical examination, testicular ultrasound, semen analysis, sperm DNA integrity evaluation (TUNEL), anti-sperm antibodies (ASA) testing, sex hormone profile evaluation (Total testosterone, LH, FSH). In addition, all patients were administered International Index of Erectile Function questionnaire (IIEF-15). Sperm parameters were compared with two age-matched healthy pre-COVID-19 control groups of normozoospermic (CTR1) and primary infertile (CTR2) subjects. Results Median values of semen parameters from recovered SARS-CoV-2 subjects were within WHO 2010 fifth percentile. Mean percentage of sperm DNA fragmentation (%SDF) was 14.1 ± 7.0%. Gelatin Agglutination Test (GAT) was positive in 3.9% of blood serum samples, but no positive semen plasma sample was found. Only five subjects (6.2%) had total testosterone levels below the laboratory reference range. Mean bilateral testicular volume was 31.5 ± 9.6 ml. Erectile dysfunction was detected in 30% of subjects. Conclusion Our data remark that COVID-19 does not seem to cause direct damage to the testicular function, while indirect damage appears to be transient. It is possible to counsel infertile couples to postpone the research of parenthood or ART procedures around three months after recovery from the infection.

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Section: Discussionmentioning

confidence: 99%

Male reproductive health after 3 months from SARS-CoV-2 infection: a multicentric study

Paoli

Pallotti

Anzuini

et al. 2022

J Endocrinol Invest

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“…They found an elevated likelihood of new‐onset ED after contracting SARS‐CoV‐2 (Chu et al, 2022 ). And another study, after adjusting for known risk factors and demographics such as obesity, circulatory disease, and diabetes, also showed a strong relationship between COVID‐19 and ED (Katz et al, 2021 ). Researchers discovered that sales of ED drugs increased significantly over the COVID‐19 epidemic, suggesting a possible correlation between COVID‐19 and ED (Hernandez et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, men have a greater severity and fatality rate from SARS‐CoV‐2 infection than women (Mukherjee & Pahan, 2021 ; Tazerji et al, 2022 ). Coronavirus disease 19 (COVID‐19) and erectile dysfunction (ED) have been linked in observational research (Ates et al, 2021 ; Katz et al, 2021 ; Sansone, Mollaioli, Ciocca, Colonnello, et al, 2021 ; Sansone, Mollaioli, Ciocca, Limoncin, et al, 2021 ). Such results, however, can be confounded by a few confounders.…”

Section: Introductionmentioning

confidence: 99%

Genetic susceptibility to COVID ‐19 may increase the risk of erectile dysfunction: A two‐sample Mendelian randomization study

2022

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Coronavirus disease 19 (COVID‐19) and erectile dysfunction (ED) have been linked in some observational research, but the causality of this association in the European population is uncertain. Therefore, the research intended to investigate the causality of susceptibility to COVID‐19 on ED. We used Mendelian randomization (MR) analysis for this research. The subjects were from two genome‐wide association studies (GWAS) of the European population, including COVID‐19 (14,134 cases and 1,284,876 controls) and ED (6175 cases and 217,630 controls). We utilized the inverse variance‐weighted (IVW) to evaluate the causality of COVID‐19 genetic susceptibility on ED. Heterogeneity and pleiotropy were determined using the Cochran's Q test and MR‐Egger regression. The robustness of the findings was verified using the Leave‐one‐out method. We obtained six single nucleotide polymorphisms (SNPs) as COVID‐19 genetic instrumental variables (IVs), and there was no significant pleiotropy, heterogeneity or bias in these IVs. MR analysis revealed the causality of genetic susceptibility to COVID‐19 on elevated risk of ED (OR IVW = 1.235, 95% CI: 1.044–1.462, p < 0.05). The present study suggested the causality of genetic susceptibility to COVID‐19 on elevated ED risk among the European population. Therefore, in order to decrease the ED risk, the European population ought to positively prevent COVID‐19.

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“…It has also been proven that the risk of developing erectile dysfunction is due to both the direct effect of the virus and damage to the vascular endothelium and other cardiovascular effects. Patients with COVID-19 were 3.3 times more likely to have erectile dysfunction with 95% CI (2.8, 3.8) [7]. However, the question of the presence of the SARS-CoV-2 virus in semen and the effect of this fact on fertility is still controversial and requires further research.…”

Section: Methodsmentioning

confidence: 99%

Reproductive health in the context of pandemic COVID-19

Nykula

Омельченко

Yelizarova

2021

Modern Medicine: The Use of Creative Industries in the Healthcare System

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The onset of the COVID-19 pandemic triggered changes in both the public and private lives of millions of people and triggered negative changes in the health of the population [1]. Studying the consequences of the pandemic and the impact of its various aspects on reproductive health is one of the issues in the focus of attention of scientists.Reproductive healthcare is a pressing issue for both the health sector and society as a whole [2]. The social significance of reproductive health is based on the increased probability of population decline and age structure change due to fertility rates decreasing in the European region, the United States, Japan, Hong Kong and other developed countries [3]. These changes might have profound economic, social, and geopolitical impacts [3].

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Increased odds ratio for erectile dysfunction in COVID-19 patients

Cited by 32 publications

References 36 publications

Male reproductive health after 3 months from SARS-CoV-2 infection: a multicentric study

Male reproductive health after 3 months from SARS-CoV-2 infection: a multicentric study

Genetic susceptibility to COVID ‐19 may increase the risk of erectile dysfunction: A two‐sample Mendelian randomization study

Reproductive health in the context of pandemic COVID-19

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