Increased odds of metabolic syndrome with consumption of high dietary advanced glycation end products in adolescents

Saha, Aparna; Poojary, Priti; Chan, Lili; Chauhan, Kinsuk; Nadkarni, Girish N.; Coca, Steven G.; Uribarri, Jaime

doi:10.1016/j.diabet.2017.01.001

Cited by 14 publications

(12 citation statements)

References 10 publications

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“…Moreover, high dAGEs was significantly associated with impaired fasting glucose regardless of sex, age, family history of cardiovascular disease and energy intake. These results are similar to a cross-sectional study in American adolescents where it was found a significant association between high dAGEs intake and MS [21]. In contrast, Angoorani et al found an association between high dAGEs and abdominal obesity and hypertriglyceridemia, however, failed to show an association with MS after adjusting for energy and macronutrients intake [20].…”

Section: Discussionsupporting

confidence: 85%

“…In order to estimate dAGEs, each subject completed a 24-hour dietary recall in three different days of the week emphasizing cooking methods and food brands. Angoorani et al and Saha et al used dietary questionnaires recorded for other purposes [20,21].…”

Section: Discussionmentioning

confidence: 99%

“…A similar cross-sectional study in American adolescents showed a significant association between high dAGEs intake and MS. Besides, an association was demonstrated with abdominal obesity and hypertriglyceridemia [21]. Given the potential impact of dAGEs intake on metabolic health, the objective of this study was to estimate the consumption of dAGEs in young Mexican adults and describe its association with risk factors for MS.…”

Section: Introductionmentioning

confidence: 99%

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Association of Dietary Advanced Glycation End Products with Metabolic Syndrome in Young Mexican Adults

Mendoza-Herrera¹,

Aradillas‐García

Mejía-Diaz

et al. 2018

Medicines

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Background: Consumption of dietary advanced glycation end products is linked to metabolic syndrome. The objective was to describe the association between dietary advanced glycation end products intake and metabolic syndrome in young Mexican adults. Methods: The present was a cross-sectional study in 126 Mexican adults 18–35 years old evaluating metabolic syndrome through the harmonized criteria. Macronutrients and dietary advanced glycation end products intake were estimated through three 24-hour dietary recalls and food composition tables. Association between metabolic syndrome and high advanced glycation end products intake (≥10,000 kU/day) was evaluated through three logistic regression models adjusted by sex, age, family history of cardiometabolic diseases and energy intake. Results: Subjects with a higher advanced glycation end products intake were more likely to have impaired fasting glucose (OR: 4.91, 95% CI 1.29–18.60, p < 0.05) and metabolic syndrome (OR: 2.67, 95% CI 0.96–7.44, p = 0.059) than those participants with low consumption of these products after adjustment of sex, age, family history of cardiovascular disease and energy intake. Conclusions: High intake of dietary advanced glycation end products was significantly associated with impaired fasting glucose and marginally with metabolic syndrome in young Mexican adults regardless of sex, age, family history of cardiovascular disease and energy intake.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of Dietary Advanced Glycation End Products with Metabolic Syndrome in Young Mexican Adults

Mendoza-Herrera¹,

Aradillas‐García

Mejía-Diaz

et al. 2018

Medicines

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“…Consumption of AGE-rich diets only causes a marginal increase in weight gain, although they were described to increase the odds of adolescents to develop metabolic syndrome [81,82]. On the other hand, AGE-restricted diets have been shown to improve insulin sensitivity in normal, overweight, and diabetic patients, showing the link between increased glycoxidative stress and impaired metabolic homeostasis [64,74,[83][84][85].…”

Section: Evidence In Human Studiesmentioning

confidence: 99%

Another Player in the Field: Involvement of Glycotoxins and Glycosative Stress in Insulin Secretion and Resistance

Matafome

2020

Diabetology

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The term glycotoxins includes the group of advanced glycation end-products (AGEs) and their precursors, most of them highly reactive intermediary compounds, such as methylglyoxal (MG). Glycotoxins were initially thought to participate in the development of diabetic complications because of their increased formation from glucose. However, they also form and accumulate in tissues since the early stages of disease, such as metabolically unhealthy obesity and prediabetes. Such accumulation has been suggested to result from dysregulated activity of detoxification systems, such as the glyoxalase system, as well as increased dietary consumption, namely from high-glucose and high-fructose foods processed at high temperatures. Although some studies may have used supraphysiological doses, in vitro systems and animal models have shown glycotoxin-induced insulin resistance. Moreover, dietary glycotoxin restriction was shown to improve insulin resistance in humans and glyoxalase (GLO)-1 upregulation improved insulin sensitivity and metabolic function. This review summarizes the current knowledge about glycotoxin involvement in the development of insulin resistance, the mechanisms involved and the usefulness of GLO-1 modulation, and a possible therapeutic strategy to improve insulin sensitivity.

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“…For example, a biscotti, with its oven-baked combination of protein and sugar, is extraordinarily high in AGEs-over 35 times higher than a poached egg [90]. This is of relevance because foods high in pre-formed AGEs have been linked to inflammation, oxidative stress and enhanced allergenicity of foods [91][92][93]; on the other hand, dietary interventions to lower exogenous AGE intake can significantly reduce systemic inflammation and oxidative stress [94].…”

Section: Deconstructing Astrofoodmentioning

confidence: 99%

Astrofood, Priorities and Pandemics: Reflections of an Ultra-Processed Breakfast Program and Contemporary Dysbiotic Drift

Logan

Prescott

2017

Challenges

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Abstract:Recognizing the importance of nutrition as part of the grand challenges faced by humanity-the current epidemic of non-communicable diseases (NCDs), sustainability and maintenance of Planetary Health-the United Nations (UN) has declared 2016-2025 the Decade of Nutrition. Research continues to underscore the extent to which ultra-processed foods dominate the contemporary nutritional landscape. Moreover, the dual role played by food technology and marketing in the expansion of ultra-processed foods is under increased scrutiny. As public health experts and clinicians contend with a crisis of NCDs, attempting to untangle a knotted assortment of interrelated strands of causation, an examination of the early origins of highly-marketed ultra-processed foods can provide valuable lessons. Here, we illuminate a little-known piece of history in the annals of ultra-processed nutritional science and childhood welfare. Astrofood was a commercially-marketed, collaborative government-industry effort that brought soy protein-enriched Twinkies as a nutritive breakfast cake to disadvantaged children; its concept and delivery demonstrated an unwillingness to deal with root-cause challenges. Although its official tenure was only about 7 years, we argue that Astrofood and its total food engineering still resonate throughout the global ultra-processed nutritional landscape. New scientific advances in nutritional psychiatry and the microbiome are on a collision course with the profits, marketing and intellectual dishonesty of the ultra-processed food industry. Solutions to the grand challenges of the Decade of Nutrition may be found in lessons from Astrofood. They provide clues to undoing the tangled knots which otherwise maintain an untenable status quo.

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Increased odds of metabolic syndrome with consumption of high dietary advanced glycation end products in adolescents

Cited by 14 publications

References 10 publications

Association of Dietary Advanced Glycation End Products with Metabolic Syndrome in Young Mexican Adults

Association of Dietary Advanced Glycation End Products with Metabolic Syndrome in Young Mexican Adults

Another Player in the Field: Involvement of Glycotoxins and Glycosative Stress in Insulin Secretion and Resistance

Astrofood, Priorities and Pandemics: Reflections of an Ultra-Processed Breakfast Program and Contemporary Dysbiotic Drift

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