Increased Numbers of Enteric Glial Cells in the Peyer’s Patches and Enhanced Intestinal Permeability by Glial Cell Mediators in Patients with Ileal Crohn’s Disease

Biskou, Olga; de-Faria, Felipe Meira; Walter, Susanna; Winberg, Martin E.; Haapaniemi, Staffan; Myrelid, Pär; Söderholm, Johan D.; Keita, Åsa V.

doi:10.3390/cells11030335

Cited by 14 publications

(9 citation statements)

References 46 publications

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“…Indeed, the function of this follicle-associated epithelium consists in sampling and transporting luminal antigens through M cells and dendritic cells to CD 4+ cells[ 32 ]. Early histological changes in Peyer’s patches were reported in ileal CD such as an increase in mast cells or erosive epithelial lesions[ 33 , 34 ]. Further, the increased number of glial cells in the Peyer’s patches of patients with ileal CD resulted in an enhanced intestinal permeability[ 34 ].…”

Section: The Ileum a Specific Part Of The Gastrointestinal Tractmentioning

confidence: 99%

“…Early histological changes in Peyer’s patches were reported in ileal CD such as an increase in mast cells or erosive epithelial lesions[ 33 , 34 ]. Further, the increased number of glial cells in the Peyer’s patches of patients with ileal CD resulted in an enhanced intestinal permeability[ 34 ]. Together these phenomena may explain the increased vulnerability of the ileal mucosa to bacterial invasion in CD patients[ 35 ].…”

Section: The Ileum a Specific Part Of The Gastrointestinal Tractmentioning

confidence: 99%

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Crohn’s disease: Why the ileum?

Richard¹,

Savoye²,

Leboutte³

et al. 2023

World J Gastroenterol

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Crohn’s disease (CD) is an inflammatory bowel disease characterized by immune-mediated flares affecting any region of the intestine alternating with remission periods. In CD, the ileum is frequently affected and about one third of patients presents with a pure ileal type. Moreover, the ileal type of CD presents epidemiological specificities like a younger age at onset and often a strong link with smoking and genetic susceptibility genes. Most of these genes are associated with Paneth cell dysfunction, a cell type found in the intestinal crypts of the ileum. Besides, a Western-type diet is associated in epidemiological studies with CD onset and increasing evidence shows that diet can modulate the composition of bile acids and gut microbiota, which in turn modulates the susceptibility of the ileum to inflammation. Thus, the interplay between environmental factors and the histological and anatomical features of the ileum is thought to explain the specific transcriptome profile observed in CD ileitis. Indeed, both immune response and cellular healing processes harbour differences between ileal and non-ileal CD. Taken together, these findings advocate for a dedicated therapeutic approach to managing ileal CD. Currently, interventional pharmacological studies have failed to clearly demonstrate distinct response profiles according to disease site. However, the high rate of stricturing disease in ileal CD requires the identification of new therapeutic targets to significantly change the natural history of this debilitating disease.

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Section: The Ileum a Specific Part Of The Gastrointestinal Tractmentioning

confidence: 99%

Section: The Ileum a Specific Part Of The Gastrointestinal Tractmentioning

confidence: 99%

Crohn’s disease: Why the ileum?

Richard¹,

Savoye²,

Leboutte³

et al. 2023

World J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…In patients with inflammatory bowel disease, the proportion of GFAP + in EGCs is increased, and its secreted mediators increase the permeability of intestinal mucosal barrier, thus aggravating inflammation. But in normal people, the medium secreted by EGCs has a protective effect on intestinal mucosa ( 51 ). ENS undergoes structural and phenotypic plastic changes during inflammation.…”

Section: Regulation Of Intestinal Nervous System On Immune Cellsmentioning

confidence: 99%

Neuroimmune regulation in Hirschsprung’s disease associated enterocolitis

Lai

Tou

2023

Front. Immunol.

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Neuroimmune pathways are important part of the regulation of inflammatory response. Nerve cells regulate the functions of various immune cells through neurotransmitters, and then participate in the inflammatory immune response. Hirschsprung’s disease (HD) is a congenital abnormal development of intestinal neurons, and Hirschsprung-associated enterocolitis (HAEC) is a common complication, which seriously affects the quality of life and even endangers the lives of children. Neuroimmune regulation mediates the occurrence and development of enteritis, which is an important mechanism. However, there is a lack of review on the role of Neuroimmune regulation in enterocolitis associated with Hirschsprung’s disease. Therefore, this paper summarizes the characteristics of the interaction between intestinal nerve cells and immune cells, reviews the neuroimmune regulation mechanism of Hirschsprung’s disease associated enterocolitis (HAEC), and looks forward to the potential clinical application value.

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“…Recently, the 51 Cr-EDTA membrane permeability was suggested to be related with the accumulation of enteric glial cells (EGC), which are known to be regulators of gastrointestinal functions. Moreover, increased paracellular permeability from EGC mediators was observed in CD patients, whereas this permeability was decreased by these mediators in controls [ 73 ].…”

Section: Intestinal Membrane Permeability and Electrophysiological Pa...mentioning

confidence: 99%

Intestinal Membrane Function in Inflammatory Bowel Disease

Nakai,

Miyake

2023

Pharmaceutics

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Inflammatory bowel disease is a set of chronic inflammatory diseases that mainly develop in the gastrointestinal mucosa, including ulcerative colitis and Crohn’s disease. Gastrointestinal membrane permeability is an important factor influencing the pharmacological effects of pharmaceuticals administered orally for treating inflammatory bowel disease and other diseases. Understanding the presence or absence of changes in pharmacokinetic properties under a disease state facilitates effective pharmacotherapy. In this paper, we reviewed the gastrointestinal membrane function in ulcerative colitis and Crohn’s disease from the perspective of in vitro membrane permeability and electrophysiological parameters. Information on in vivo permeability in humans is summarized. We also overviewed the inflammatory bowel disease research using gut-on-a-chip, in which some advances have recently been achieved. It is expected that these findings will be exploited for the development of therapeutic drugs for inflammatory bowel disease and the optimization of treatment options and regimens.

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Increased Numbers of Enteric Glial Cells in the Peyer’s Patches and Enhanced Intestinal Permeability by Glial Cell Mediators in Patients with Ileal Crohn’s Disease

Cited by 14 publications

References 46 publications

Crohn’s disease: Why the ileum?

Crohn’s disease: Why the ileum?

Neuroimmune regulation in Hirschsprung’s disease associated enterocolitis

Intestinal Membrane Function in Inflammatory Bowel Disease

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