Increased numbers of CD68 antigen positive dendritic epidermal cells and upregulation of CLA (cutaneous lymphocyte-associated antigen) expression on these cells in various skin diseases

Nakamura, Koichiro; Yasaka, Nami; Asahina, Akihiko; Kato, Mitsuyasu; Miyazono, Kohei; Furue, Masutaka; Tamaki, Kunihiko

doi:10.1016/s0923-1811(98)00038-3

Cited by 27 publications

(24 citation statements)

References 18 publications

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“…9 When pathological stimuli such as chemokines and adhesion molecules are locally produced and exert their function, not only macrophages but also dendritic cells may proliferate and express CD68 antigen, depending on the disease condition. 10 We regarded CD68-positive interstitial cells with a mononuclear round or spindle appearance as macrophages, although this evaluation may be limited. The study of interstitial macrophage Peritubular αSMA was strongly correlated with interstitial macrophages (Mf; C).…”

Section: Discussionmentioning

confidence: 99%

Correlations of tissue macrophages and cytoskeletal protein expression with renal fibrosis in patients with diabetes mellitus

et al. 2006

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The expression of mesangial alphaSMA may play a role in the progression of glomerular damage, while, on the other hand, newly acquired mesangial vimentin seems to be attenuated by heavy proteinuria. In addition, it was suggested that peritubular alphaSMA-positive myofibroblastic cells, in collaboration with interstitial macrophages, contribute to the progression of interstitial fibrosis in diabetic nephropathy.

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Section: Discussionmentioning

confidence: 99%

Correlations of tissue macrophages and cytoskeletal protein expression with renal fibrosis in patients with diabetes mellitus

et al. 2006

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“…Several antigens were reported in the bullous skin lesions, such as bullous pemphigoid antigen 2 (bullous pemphigoid), 49 130-kDa polypeptide pemphigus vulgaris 29 and cutaneous lymphocyte-associated antigen. 40 …”

Section: Increased Density Of Both Neutrophils and Eosinophils In Bulmentioning

confidence: 99%

“…The marked increase in CD68+ histiocytes or dendritic cells in the epidermis and dermis of the bullous skin lesions is in line with previous findings in other skin dermatoses. 40 Therefore, the presence of CD68+ signals in the epidermis of both normal (occasional) and lesional (frequent) skin may reflect the presence of dendritic cells or histiocytes. It is tempting to speculate that the CD68+ cells have a role in the Immunoreactivity score was evaluated as by other groups 12a 13 .…”

Section: High Density Of Cd68+ Cells In Bullous Skin Lesionsmentioning

confidence: 99%

Immunohistological analysis of immune cells in blistering skin lesions

Hussein

Ali²,

Omar³

2007

J Clin Pathol

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Background: Bullous skin lesions are characterised by the presence of intraepidermal or subepidermal bullae. Although inflammatory cell infiltrate is a constant feature in these lesions, their immunophenotypic characterisation is still incomplete. Aim: To determine whether the development of bullous skin diseases is associated with changes in the inflammatory cell infiltrate. Materials and methods: 34 cases representing lesions with both intraepidermal and subepidermal bullae were examined using immunoperoxidase staining methods and antibodies targeting antigens for histiocytes (CD68), B cells (CD20+), T cells (CD3+), T cells with cytotoxic potential (T cell intracellular associated antigen, TIA1+) and activity (granzyme B, GRB+). The adjacent normal skin (lesions) and an additional five cases of normal skin were also examined (controls). Results: The transition from normal skin to lesional skin (lesions with intraepidermal and subepidermal bullae) was associated with a significant increase (p(0.05) in the density of total inflammatory cell infiltrate, CD68+ cells, CD3+ T lymphocytes, CD20+ B lymphocytes, TIA1+-resting cytotoxic T cells and GRB+ T cells with cytotoxic activity. Conclusions: The increase in inflammatory cell infiltrate during the transition from normal to lesional skin may reflect the presence of an increased antigenicity of the lesional cells or a response to some basement membrane components. CD68+ and CD3+ cells, especially the resting cytotoxic ones, achieved numerical dominance in these lesions. Cell-mediated immunity seems to have critical role in the development of these lesions.

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“…During this transition, some effector and memory T cells acquire new molecular keys such as the cutaneous lymphocyte antigen (CLA), which allow them to preferentially enter inflamed skin where the appropriate ligands are expressed on cutaneous microvascular endothelial cells (Tietz et al, 1998). It could be shown that the majority of T cells in inflamed skin lesions such as atopic dermatitis, psoriasis vulgaris, lichen planus, discoid lupus erythematosus, and cutaneous T cell lymphoma indeed express CLA on their cell surface (Heald et al, 1993;Nakamura et al, 1998). The majority of CLA þ memory T cells express the chemokine receptor (CCR)4 (Campbell et al, 1999).…”

mentioning

confidence: 99%

Role of the Chemokine Receptor CCR4 and its Ligand Thymus- and Activation-Regulated Chemokine/CCL17 for Lymphocyte Recruitment in Cutaneous Lupus Erythematosus

Wenzel

Henze

Wörenkämper

et al. 2005

Journal of Investigative Dermatology

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Skin-infiltrating T lymphocytes are thought to play a major role in the pathogenesis of cutaneous lupus erythematosus (CLE). In this study, we investigated the role of the chemokine receptor 4 (CCR4) and its ligand thymus- and activation-regulated chemokine (TARC/CCL17) for the recruitment of T cells in inflamed skin of patients with CLE. We found significant numbers of CCR4+ T lymphocytes in the skin of all patients with CLE. Interestingly, a subset of patients with disseminated scarring skin involvement were characterized by both lesional and circulating CD8+ T cells expressing CCR4. Destruction of epidermal and adnexal structures was histomorphologically associated with CCR4+ cytotoxic T cells invading basal layers of the epidermis where keratinocytes showed apoptotic death. The CCR4 ligand TARC/CCL17 was strongly expressed in skin lesions and elevated in the serum of CLE patients. The functional relevance of lymphocytic CCR4 expression could be confirmed by TARC/CCL17-specific in vitro migration assays. Our investigations suggest that CCR4 and TARC/CCL17 play a role in the pathophysiology of CLE. In particular, cytotoxic CD8+ T cells expressing CCR4 appear to be involved in scarring subtypes of CLE.

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Increased numbers of CD68 antigen positive dendritic epidermal cells and upregulation of CLA (cutaneous lymphocyte-associated antigen) expression on these cells in various skin diseases

Cited by 27 publications

References 18 publications

Correlations of tissue macrophages and cytoskeletal protein expression with renal fibrosis in patients with diabetes mellitus

Correlations of tissue macrophages and cytoskeletal protein expression with renal fibrosis in patients with diabetes mellitus

Immunohistological analysis of immune cells in blistering skin lesions

Role of the Chemokine Receptor CCR4 and its Ligand Thymus- and Activation-Regulated Chemokine/CCL17 for Lymphocyte Recruitment in Cutaneous Lupus Erythematosus

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