Increased number of substance P positive nerve fibres in interstitial cystitis

Pang, Xinzhu; Marchand, James E.; Sant, Grannum R.; Kream, Richard M.; Theoharides, Theoharis C.

doi:10.1111/j.1464-410x.1995.tb07384.x

Cited by 223 publications

(111 citation statements)

References 35 publications

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“…[1][2][3][4] In addition, the extensive tissue remodeling seen in some clinical forms of bladder inflammation such as interstitial cystitis, 4 along with increased urinary levels of histamine and tryptase 5 suggest a role for mast cells. Because both mast cells 6 -8 and NK-1 receptors are increased in bladder biopsies of interstitial cystitis (IC) patients, 9,10 it is tempting to propose a role for sensory peptides-mast cell communication in the pathogenesis of this disorder.…”

mentioning

confidence: 99%

Gene Expression Profiling of Mouse Bladder Inflammatory Responses to LPS, Substance P, and Antigen-Stimulation

Saban

Nguyen

Hammond

et al. 2002

The American Journal of Pathology

110

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Inflammatory bladder disorders such as interstitial cystitis (IC) deserve attention since a major problem of the disease is diagnosis. IC affects millions of women and isClinical and animal models of acute and chronic urinary bladder inflammation have provided several lines of evidence suggesting a central role of mast cells, sensory nerves, and neurokinin (NK)-1 receptors. Fundamental work regarding the participation of sensory nerves and mast cells in cystitis provides indirect evidence, such as increased numbers of mast cells in the detrusor and submucosa, and morphological evidence of mast cell activation and degranulation. [1][2][3][4] In addition, the extensive tissue remodeling seen in some clinical forms of bladder inflammation such as interstitial cystitis, 4 along with increased urinary levels of histamine and tryptase 5 suggest a role for mast cells. Because both mast cells 6 -8 and NK-1 receptors are increased in bladder biopsies of interstitial cystitis (IC) patients, 9,10 it is tempting to propose a role for sensory peptides-mast cell communication in the pathogenesis of this disorder.Experimentally, we have used classical morphometric analysis and microarray technology to determine the role of mast cells, NK-1 receptors, and bacterial toxins in animal models of cystitis. Time-course experiments indicated early and late genes involved in bladder inflammatory responses. 11 The availability of mice genetically deficient in neurokinin-1 receptor (NK-1R Ϫ/Ϫ ) allowed us to propose a mandatory role of SP receptors in cystitis. 12 We also determined genes that depend on the presence of tissue mast cells for their expression by comparing inflammatory responses in mast cell-deficient (Kit W /

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mentioning

confidence: 99%

Gene Expression Profiling of Mouse Bladder Inflammatory Responses to LPS, Substance P, and Antigen-Stimulation

Saban

Nguyen

Hammond

et al. 2002

The American Journal of Pathology

110

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“…Ghrelin-positive MCs localization near the autonomic nerves in the rat stomach wall correlates with results detecting MCs near the peptidergic nerves in other organs and species [23][24][25]. According to earlier studies, the neuropeptides can influence the secretion of MC cytokines which exert their modulatory effect in neurogenic inflammation [66][67][68]. Moreover, in vivo studies have been performed to confirm that the catecholamines, norepinephrine and epinephrine act as direct ghrelin secretagogues.…”

Section: Resultsmentioning

confidence: 83%

Distribution of ghrelin-positive mast cells in rat stomach

Stefanov

Ananiev

Ivanova

et al. 2017

Biotechnology & Biotechnological Equipment

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It is known that the gastrointestinal peptide hormone ghrelin is expressed in human and rodent B lymphocytes, T lymphocytes, monocytes and natural killer cells. However, there are no data about ghrelin expression by mast cells. These facts, as well as the common progenitor cells of mast cells and the above-mentioned immune cells, motivated us to undertake the current work in order to prove that like other granulocytes, rat gastric mast cells are capable of immunohistochemical expression of ghrelin. Gastric wall sections of Wistar rats were studied immunohistochemically for detection of ghrelin and tryptase and histochemically for toluidine blue in order to identify ghrelinpositive mast cells as well as to establish their localization and distribution. Results showed that mast cell granules expressed ghrelin. The ghrelin-positive mast cells were the least numerous as compared to tryptase-positive mast cells and toluidine blue-positive mast cells. Based on the observed expression of ghrelin in granules of mast cells localized in the rat gastric wall, we suggested that this type of cell can be regarded as an important source of ghrelin and suggested that ghrelin may exert different physiological functions, such as regulation of muscular, epithelial and glandular functions.

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“…The pathogenesis of IC/BPS is now better understood; and as well as epithelial inflammatory histopathology and chemistry, [6][7][8] the presence of aberrant peripheral and central nerve function in this condition is well documented. [9][10][11][12] However, a complete understanding of the autonomic control of the human bladder is still elusive.…”

Section: Introductionmentioning

confidence: 99%

Chiropractic care of interstitial cystitis/painful bladder syndrome associated with pelvic lumbar spine dysfunction: a case series

Cashley¹,

Cashley²

2012

Journal of Chiropractic Medicine

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Objective: The purpose of this case series is to describe findings for patients with bladder pain syndrome (BPS) or interstitial cystitis (IC) who responded positively under chiropractic care. Clinical Features: Eight cases were selected retrospectively reviewed from 2 independent chiropractic clinics in Scotland. Cases were selected if patients reported bladder dysfunction problems and responded positively to chiropractic care. The cases in this report describe the range of patients affected by this condition. Each patient was treated using chiropractic methods that were specific to the individual case. Intervention and Outcomes: The patients selected for this case series showed positive response to chiropractic care over various lengths of time and numbers of treatments. Some of the chiropractic patients who had chronic spinal conditions had reoccurrence of bladder symptoms during an exacerbation of mechanical spinal problems. Conclusion: This case series highlights that bladder and urinary problems may be associated with spinal dysfunction for some patients.

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Increased number of substance P positive nerve fibres in interstitial cystitis

Cited by 223 publications

References 35 publications

Gene Expression Profiling of Mouse Bladder Inflammatory Responses to LPS, Substance P, and Antigen-Stimulation

Gene Expression Profiling of Mouse Bladder Inflammatory Responses to LPS, Substance P, and Antigen-Stimulation

Distribution of ghrelin-positive mast cells in rat stomach

Chiropractic care of interstitial cystitis/painful bladder syndrome associated with pelvic lumbar spine dysfunction: a case series

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