Increased number of primed activated CD8+CD38+CD45RO+T cells predict the decline of CD4+T cells in HIV-1-infected patients

Bofill, Margarita; Mocroft, Amanda; Lipman, Marc; Medina, Eva; Borthwick, Nicola; Sabin, Caroline; Timms, Anthony; Winter, Michael E.; Baptista, Leandra Santos; Ma, Jun; Lee, C A; Phillips, Aled O.; Jánossy, G

doi:10.1097/00002030-199607000-00005

Cited by 175 publications

(127 citation statements)

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“…More than a decade ago, it was shown that in AIDS, CD8 ϩ T cells show increased expression of CD38 [46]. It was later shown that the expansion of these cells precedes the decline in CD4 ϩ T cells and development of AIDS [47], making CD38 not only a useful but the most reliable prognostic marker [48]. However, CD38 may also be more directly involved in AIDS pathogenesis because there is data postulating an inhibitory role of CD38 in HIV binding to CD4 [49].…”

Section: Myeloid Cellsmentioning

confidence: 99%

The metamorphosis of a molecule: from soluble enzyme to the leukocyte receptor CD38

Ferrero

Malavasi

1999

Journal of Leukocyte Biology

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Human CD38 is a 45-kDa type II membrane glycoprotein with an intricate pattern of expression in leukocytes, although evidence is accumulating of its quite widespread expression in cells of nonvascular origin. CD38 is a member of a nascent eukaryotic gene family encoding cytosolic and membrane-bound enzymes whose substrate is NAD, a coenzyme ubiquitously distributed in nature. Functionally, CD38 is an eclectic molecule with the ability not only to catalyze but also to signal, to mobilize calcium, and to adhere to itself, to hyaluronan, and to other ligands. Interaction with CD38 on various leukocyte subpopulations has profound though diverse consequences on their life-span, but these effects seem to be independent of the enzymatic activity of the molecule. CD38 challenges our expectations of a surface molecule and we must sift through its many guises to unmask its true nature. J. Leukoc. Biol. 65: 151-161; 1999.

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Section: Myeloid Cellsmentioning

confidence: 99%

The metamorphosis of a molecule: from soluble enzyme to the leukocyte receptor CD38

Ferrero

Malavasi

1999

Journal of Leukocyte Biology

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“…progression independent of the plasma viral load and peripheral blood (PB) CD4þ T-cell counts (7)(8)(9)(10)(11)(12)(13). Furthermore, CD38 expression on CD8þ T-cells correlates with HIV-1 disease progression, and it also predicts further declines in PB CD4þ T-cells (11,14).…”

mentioning

confidence: 99%

“…Furthermore, CD38 expression on CD8þ T-cells correlates with HIV-1 disease progression, and it also predicts further declines in PB CD4þ T-cells (11,14). Initiation of antiretroviral therapy (ART) leads to a dramatic decrease of both the relative and absolute number of CD8þCD38þ T-cells in HIV-1þ patients (15)(16)(17)(18), and persistence of high numbers of CD8þCD38þ T-cells has been associated with ART failure (19,20).…”

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confidence: 99%

Relationship between CD38 expression on peripheral blood T‐cells and monocytes, and response to antiretroviral therapy: A one‐year longitudinal study of a cohort of chronically infected ART‐naive HIV‐1+ patients

Almeida

Cordero

Almeida

et al. 2006

Cytometry Part B Clinical

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Background: HIV-1 infection has been associated with high expression of CD38 on peripheral blood (PB) CD81 and CD41 T-cells, which has been related with poor prognosis in untreated HIV-11 patients. In turn, CD38 expression on PB monocytes from HIV-11 individuals and its behavior after starting antiretroviral therapy (ART) have been poorly studied.Methods: CD38 expression on PB CD81 and CD41 T-lymphocytes and monocytes was prospectively analyzed in 30 ART-naive HIV-11 patients, using a quantitative multiparameter flow cytometry approach. Patients were tested prior to therapy, and at weeks 12, 14, 18, 112, and 152 after ART.Results: Prior to ART, CD38 expression was significantly increased on PB CD81 and CD41 T-cells and monocytes; despite a significant decrease after ART, CD38 expression remained abnormally high on PB CD81 T-cells and monocytes, even after one year of therapy, in the absence of detectable plasma viral load. The ART-induced early changes on CD38 expression by PB T-cells and monocytes differed among the cell subsets analyzed and patient groups, probably reflecting an interaction between the direct effects of therapy and a redistribution of the PB compartments of T-cells and monocytes. Hierarchical clustering analysis showed that the overall pattern of changes in CD38 expression observed early after starting ART was predictive of a better response to therapy, not only for PB CD81 T-cells, but also for CD41 T-cells and monocytes. Accordingly, those HIV-11 patients, who experienced a more pronounced increase in CD38 expression on both PB CD41 T-cells and monocytes after 2 weeks of ART, showed a more rapid viral clearance, which might reflect decreased HIV-1 replication in lymph nodes and other tissues, and a partial restoration of hematopoiesis.Conclusions: Combined quantitative measurement of CD38 expression on PB monocytes, and CD81 and CD41 T-cells is a more useful tool for monitoring HIV-11 patients under ART, rather than quantitation of CD38 expression on PB CD81 T-lymphocytes alone. q

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“…Se ha demostrado que durante la infección por el VIH-1 existe un estado de activación inmune persistente, denominado hiperactivación inmunológica, fenómeno que se asocia con múltiples trastornos funcionales en los leucocitos y con apoptosis acelerada de esas células (11,36). El nivel de células T CD4+ y CD8+ activadas se considera como un factor pronóstico independiente de la reducción en el recuento de linfocitos T CD4+ y de la progresión al sida (11,36,37).…”

Section: Figura 4 Activación Inmunológica Y Presencia De Infeccionesunclassified

Efecto de las infecciones oportunistas sobre las subpoblaciones de leucocitos en individuos infectados con el virus de inmunodeficiencia humana tipo 1

et al. 2008

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Introducción. La presencia de infecciones por patógenos oportunistas en pacientes con síndrome de inmunodeficiencia adquirida representa un coestímulo para acelerar la progresión de la infección por el VIH-1. A pesar del papel preponderante que varias subpoblaciones de leucocitos tienen en la respuesta antiinfecciosa, poco se ha estudiado el comportamiento de esas células en pacientes positivos para VIH-1 que presentan infecciones oportunistas. Objetivo. Evaluar cuantitativamente las subpoblaciones celulares más importantes de la inmunidad innata y adaptativa en sangre periférica de adultos infectados con el VIH-1 (con antecedentes de infecciones oportunistas y sin ellos). Materiales y métodos. El número absoluto de las diferentes subpoblaciones de leucocitos fue determinado por citometría de flujo; para cada subpoblación, este número se correlacionó con la carga viral, el recuento de linfocitos T CD4+ y la expresión de marcadores de activación inmunológica en células T CD4+ y CD8+. Resultados. Los pacientes crónicamente infectados por el VIH-1 presentan deficiencia cuantitativa de varias subpoblaciones de leucocitos, que es más significativa en aquellos pacientes con una infección oportunista activa al momento de la evaluación, lo cual indica que la coinfección VIH-1/agentes oportunistas puede potenciar la inmunodeficiencia al asociarse con una reducción significativa de las diferentes subpoblaciones de leucocitos. Conclusiones. Estos hallazgos sugieren la necesidad de hacer un diagnóstico temprano de la infección por el VIH-1 y un uso racional de la terapia antirretroviral de manera que se impida que los pacientes lleguen a desarrollar infecciones oportunistas, así como la necesidad de establecer estrategias de inmunoterapia para pacientes positivos para VIH-1 con el fin de reestablecer más integralmente la competencia inmune.Palabras clave: infecciones oportunistas relacionadas con sida/inmunología, leucocitos, VIH-1, activación de linfocitos, células dendríticas, células asesinas naturales. Effect of opportunistic infections on the frequency of leukocyte subpopulations from type-1 human immunodeficiency virus infected individualsIntroduction. The presence of opportunistic infections in patients with acquired immunodeficiency syndrome favors the progression of HIV-1 infection. Despite the key role that several leukocyte subpopulations exhibit during the anti-infectious response, few studies have focused on the role of these cells in HIV-1-infected patients with active opportunistic infections. Objective. The quantity of several innate and adaptive cell subpopulations was evaluated in whole peripheral blood of HIV-1-infected patients, with and without a history of opportunistic infections. Materials and methods. The absolute number of each leukocyte subpopulation was evaluated by flow cytometry, and for each cell subpopulation, this number was correlated with viral load, CD4+ T cell count and the expression of activation markers on CD4+ and CD8+ T lymphocytes. Results. Chronically HIV-1 infected patients exhib...

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Increased number of primed activated CD8+CD38+CD45RO+T cells predict the decline of CD4+T cells in HIV-1-infected patients

Cited by 175 publications

References 0 publications

The metamorphosis of a molecule: from soluble enzyme to the leukocyte receptor CD38

The metamorphosis of a molecule: from soluble enzyme to the leukocyte receptor CD38

Relationship between CD38 expression on peripheral blood T‐cells and monocytes, and response to antiretroviral therapy: A one‐year longitudinal study of a cohort of chronically infected ART‐naive HIV‐1+ patients

Efecto de las infecciones oportunistas sobre las subpoblaciones de leucocitos en individuos infectados con el virus de inmunodeficiencia humana tipo 1

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