Increased number of oocytes retrieved in frozen donor oocyte cycles does not have a negative impact on outcomes

Abstract

A total of 47 women were allocated, 23 were assigned to the GnRHa arm and 24 were assigned to estrogen and progesterone treatment arm. Patients' characteristics including age, BMI, gravidity, parity as well as basal FSH levels didn't differ significantly between the study groups. Treatment's characteristics including the FSH dosage, duration of stimulation, peak estradiol levels, number of oocytes retrieved, fertilization rates and number of embryo transferred also didn't differ significantly between the study groups. The implantation rate was 56.5% and 37.5% in the GnRHa arm and in the estrogen and progesterone arm, respectively (P¼ 0.1). The clinical pregnancy rate was higher in the GnRHa treatment group compared to the estrogen and progesterone group although the difference was not statistically significant (60.8% vs. 50%, P¼ 0.45). Of note, no cases of OHSS were observed in both study groups.CONCLUSIONS: Luteal support using GnRHa alone is as effective and safe as using intensive estrogen and progesterone supplementation following GnRHa triggering in high responders. This new approach in fresh embryo transfer in high responders after GnRHa triggering offer a more convenient luteal support without compromising implantation and clinical pregnancy rates.