Increased nitric oxide stress is associated with migraine

Hj, Gruber; Bernecker, Claudia; Lechner, Anita; Weiss, S.; Wallner-Blazek, M; Meinitzer, Andreas; Höbarth, Gerald; Renner, Wilfried; Fauler, Günter; Horejsi, Renate; Fazekas, Franz; Truschnig-Wilders, M.

doi:10.1111/j.1468-2982.2009.01964.x

Cited by 47 publications

(57 citation statements)

References 27 publications

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“…Oxidant-antioxidant balance disorders lie under several acute and chronic diseases of the central nervous system (CNS). It is believed that oxidative stress plays a role in the pathogenesis of migraine [1,2].…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and decreased thiol level in patients with migraine: cross-sectional study

Eren

Dirik²,

Neşeli̇oğlu

et al. 2015

Acta Neurol Belg

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Although migraine is a neurological disorder known since long, its physiopathology remains unclear. Recent studies suggest that migraine is associated with oxidative stress; however, they report divergent results. The aim of the present study was to evaluate total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and serum thiol level in migraine patients with or without aura. The study group consisted of 141 migraine patients. The control group included 70 healthy subjects. TAS, TOS, OSI were evaluated using a method developed by Erel. Serum thiol level was measured using the Hu method. No difference was found in TAS, TOS, OSI between the patients and controls. The level of thiol was significantly lower in patients than in controls. Negative correlations were detected between thiol level and Migraine Disability Assessment score in patients. Although TAS, TOS, and OSI were similar to those of the control group, serum thiol level, an important marker of antioxidant capacity, was significantly lower in migraines compared with controls, and caused more serious disability. Novel treatment approaches may be developed based on these data, and compounds containing thiol, such as alpha lipoic acid and N-acetyl cysteine, may be used in prophylaxis.

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Section: Introductionmentioning

confidence: 99%

Oxidative stress and decreased thiol level in patients with migraine: cross-sectional study

Eren

Dirik²,

Neşeli̇oğlu

et al. 2015

Acta Neurol Belg

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“…Asymmetric dimethylarginine (ADMA) is nitric oxide synthase inhibitor and ADMA has close association with endothelial dysfunction and oxidative stress [6]. There is limited number of studies investigating ADMA levels in patients with migraine [7,8]. No difference has been found in ADMA and NO levels between migraine patients during interictal period and healthy controls in a previous study [7].…”

Section: Introductionmentioning

confidence: 99%

Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine

et al. 2011

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Asymmetric dimethylarginine (ADMA) has been found as correlated with endothelial dysfunction and oxidative stress. There are few studies regarding ADMA and nitric oxide (NO) levels in patients with migraine and alterations of ADMA and NO levels during migraine attack are not well-known. Therefore, in present study, we aimed to measure NO and ADMA levels in patients with migraine and compare them with the control group to investigate the correlation between migraine, oxidative stress and endothelial dysfunction. The migraine group consisted of 59 patients, including 22 suffering from migraine with aura and 37 suffering from migraine without aura. The control group consisted of 31 healthy volunteers without headache. The patients in migraine group were divided into subgroups based on whether attack period was present or not and whether it was migraine with or without aura. Plasma ADMA levels were measured using an enzyme-linked immunosorbent assay method. Migraine patients had higher concentrations of NO (35.6 ± 7.7, 31.0 ± 6.2 lmol/L, respectively, p = 0.005) and ADMA (0.409 ± 0.028, 0.381 ± 0.044 lmol/L, respectively, p = 0.001) levels when compared with the healthy controls. During migraine attack, NO and ADMA levels were found to be significantly higher in migraine group as compared to control group (respectively, p = 0.015, p = 0.014). Similarly, NO and ADMA levels in the patients with migraine in the interictal period were found to be significantly higher as compared to control group (p = 0.011, p = 0.003). In conclusion, higher ADMA and NO levels of patients with migraine supported that oxidative stress and endothelial dysfunction may have a role in migraine pathogenesis.

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“…This longer R-APWCMtd suggests an increased arterial distensibility (or reduced arterial stiffness) of cerebral arterial network, because the pulsatile pressure gradient propagates more slowly in presence of increased arterial distensibility (according to Bramwell and Hill equation) [1]. A recent study hypothesizes that increased nitric oxide (NO) in the headache-free period is associated with migraine [3]. The increased NO, by reducing the vascular tone altering smooth muscle tone, leads to vasodilatation of cerebral arteries and could increase the arterial distensibility of cerebral vessels [4] that we found in our migraine patients.…”

Section: S130mentioning

confidence: 99%

A new near-infrared spectroscopy parameter as marker for patients with migraine

Viola¹,

Viola

Litterio³

et al. 2013

Neurol Sci

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Due to the lack of markers for migraine, diagnosis relies entirely on symptomatology. The aim is to evaluate the utility of a new near-infrared spectroscopy parameter as potential marker for patients with episodic migraine with (MA?) and without aura (MA-) during the interictal period of migraine. We studied 10 patients with MA? (age 39.5 ± 12.2 years) and 10 with MA-(age 40.3 ± 10.2 years), according to ICHD-II criteria 2004, during the interictal period of migraine and 15 age and sex matched healthy control subjects. The cases and controls were free from vascular risk factors and migraine prophylactic medications. At rest in all the participants, the time delay in millisecond (ms), between the R-wave of an electrocardiogram and the arterial pulse wave of cerebral microcirculation detected by transcranial near-infrared Spectroscopy (R-APWCMtd) on the frontal cortex of both side, was determined. The patients with migraine had a significantly longer R-APWCMtd than the control subjects: the patients with MA?: ?38.3 ms, p \ 0.0002; the patients with MA-: ?34.7 ms, p \ 0.0002, and there was no significant difference between MA? and MA-, p = 0.71. We used receiver-operator characteristic (ROC) curve to assess the diagnostic potential of the R-APWCMtd measurement for diagnosis of migraine; we found an ROC area of 0.92, p \ 0.0001, sensitivity 77.8 %, specificity 100 % and cutoff of 242 ms. Our study seems to indicate that the longer R-APWCMtd is independently associated with a diagnosis of migraine, and may be considered a new marker for migraine, especially in patients with MA?.

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Increased nitric oxide stress is associated with migraine

Cited by 47 publications

References 27 publications

Oxidative stress and decreased thiol level in patients with migraine: cross-sectional study

Oxidative stress and decreased thiol level in patients with migraine: cross-sectional study

Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine

A new near-infrared spectroscopy parameter as marker for patients with migraine

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