Increased Nitric Oxide Production in Hypotensive Hemodialysis Patients

Lin, Shih‐Hua; Lin, Yuh‐Feng; Diang, Liang-Kuang; Yu, Fu-Chiu; Shieh, Shyh‐Ming

doi:10.1097/00002480-199603000-00272

Cited by 7 publications

(11 citation statements)

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“…A major determinant of serum NO 3 − and NO 2 − is the catabolism of proteins and amino acids, and dietary sources are another (24). Nonetheless, research has suggested a possible association of increased NO metabolite concentrations in plasma with enhanced NO production and decreased renal function (25). The concentration of NO 2 − plus NO 3 − in serum has been observed to decrease more than either blood urea nitrogen (BUN) or creatinine following dialysis, and the concentrations of these 2 analytes have been suggested as a potential indicator of renal impairment (26).…”

Section: Discussionmentioning

confidence: 99%

Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-Stage Renal Disease: A Proof of Principle

et al. 2008

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Background: Initial screening of potential biomarkers for monitoring dialysis was performed with saliva samples collected from patients with end-stage renal disease (ESRD). A more thorough analysis of the most promising markers identified in the initial screening was conducted with saliva samples acquired at hourly intervals throughout dialysis to monitor analyte concentrations as dialysis progressed. We observed that salivary nitrite (NO2−) and uric acid (UA) concentrations consistently decreased as dialysis proceeded. Methods: Solution-based colorimetric-detection chemistries for NO2− and UA were converted to a test strip format to produce a simple method for semiquantitatively measuring NO2− and UA concentrations in the clinic or at the patient’s home. We assessed the test strips with saliva samples collected from both ESRD patients undergoing dialysis and healthy control volunteers to qualitatively monitor the effect of dialysis on salivary NO2− and UA. We used computer software to analyze digital images of the resulting test strip color intensities. Results: Test strip measurements showed that mean salivary concentrations of NO2− and UA were decreased in ESRD patients by 86% and 39%, respectively, compared with 15% and 9% for time-matched controls. Comparison of test strip results with calibrated solution-based assays suggests that the test strips can semiquantitatively measure salivary concentrations of NO2− and UA. Conclusions: The colorimetric test strips monitored changes in salivary NO2− and UA concentrations that occurred in ESRD patients during dialysis. The test strips may prove useful for noninvasively evaluating dialysis progress and may also be useful for monitoring renal disease status.

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Section: Discussionmentioning

confidence: 99%

Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-Stage Renal Disease: A Proof of Principle

et al. 2008

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“…Formed via NO synthase (NOS), NO undergoes a short half‐life and rapidly metabolizes to nitrate and nitrite – markers of NO production – and increase in concentration in IDD patients . Indeed, previous studies show that plasma total nitrate and nitrite concentration was higher in IDD patients than those without (NIDD) during dialysis . However, only a few papers studying intradialysis blood pressure changes have measured dialysate concentrations of nitrate and nitrite at discrete time points during HD .…”

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confidence: 99%

Nitric oxide production and blood pressure reduction during haemodialysis

et al. 2014

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“…In addition, the number of episodes of hypotension that required clinical intervention was significantly reduced with the circulator intervention (P = 0.028). It is noteworthy that the circulator intervention may be also effective for the hemodialysis patient with chronic hypotension defined as SBP less than 100 mmHg in the interdialytic period [23,24]. One of our subjects had chronic hypotension and appeared to respond well to the intervention.…”

Section: Discussionmentioning

confidence: 99%

Effects of the Intermittent Pneumatic Circulator on Blood Pressure during Hemodialysis

Hsu

Chang

Huang³

et al. 2010

Sensors

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Hypotension is frequently reported during hemodialysis. This study aimed to examine the effect of the intermittent pneumatic circulator on blood pressure during hemodialysis. Sixteen subjects with chronic hemodialysis were recruited. Each subject randomly received two test conditions on separate days, hemodialysis with and without the circulator. The circulator was applied to the subject on lower extremities during 0.5–1 hr, 1.5–2 hr, 2.5–3 hr, and 3.5–4 hr of hemodialysis. Systolic and diastolic blood pressures (SBP and DBP) and heart rate (HR) were analyzed at pre-dialysis, 1 hr, 2 hr, and 3 hr of hemodialysis. Stroke volume (SV) and cardiac output (CO) were evaluated between 2.5 and 3.0 hr of hemodialysis. Blood chemicals (sodium, calcium, potassium, and phosphorous) and Kt/V before and after each hemodialysis session were analyzed. The number of episodes of hypotension was also recorded. The circulator intervention significantly improved SBP and DBP across all time points (P = 0.002 for SBP; P = 0.002 for DBP). The frequency of hypotension was significantly decreased (P = 0.028). SV and CO were significantly improved with the circulator intervention (P = 0.017 for SV; P = 0.026 for CO) and no statistical significances were found on blood chemicals or Kt/V analyses. The results suggested that the circulator intervention helps stabilize blood pressure and appears to be a practical treatment. Future studies are suggested to develop new circulator innovations with sensor feedback systems to enhance safety and maximize treatment efficiency.

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Increased Nitric Oxide Production in Hypotensive Hemodialysis Patients

Cited by 7 publications

References 0 publications

Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-Stage Renal Disease: A Proof of Principle

Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-Stage Renal Disease: A Proof of Principle

Nitric oxide production and blood pressure reduction during haemodialysis

Effects of the Intermittent Pneumatic Circulator on Blood Pressure during Hemodialysis

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