Increased Neutrophil/Lymphocyte Ratio in Patients with Depression is Correlated with the Severity of Depression and Cardiovascular Risk Factors

Sünbül, Esra Aydın; Sünbül, Murat; Yanartaş, Ömer; Çengiz, Fatma Fariha; Bozbay, Mehmet; Sarı, İbrahim; Güleç, Handan

doi:10.4306/pi.2016.13.1.121

Cited by 99 publications

(55 citation statements)

References 28 publications

(32 reference statements)

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“…Compared with normal controls, NLR was significantly higher in patients with MDD, and then reduced to the control group's level after treatment with selective serotonin inhibitors (SSRIs), accompanied by remission of depressive symptoms (Demircan et al, 2016). In addition, multiple studies have shown the same association between increased NLR and depression (Demir et al, 2015;Aydin et al, 2016;Ekinci and Ekinci, 2017). A recently published study showed that NLR was associated with depression in female Chinese adults (aged 40.5 ± 11.6 years) (Meng et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

NLR Is Associated With Geriatric Depression in Chinese Women: A Community-Based Cross-Sectional Study in Eastern China

Liang

Zhang

et al. 2020

Front. Psychol.

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In recent years, the prevalence of depression has been increasing, causing a serious global burden of disease. Previous studies have proved that low-grade inflammation is involved in the process of depression. To explore the role of inflammation in the pathogenesis of senile depression, neutrophil to lymphocyte ratio (NLR) was used in this study, as a biological marker for non-specific inflammation. The present study was conducted among elderly adults from a randomly selected Community in Yangpu District, Shanghai from November 1 to December 30, 2017. 665 participants were included in the present study, including 276 males (median age was 68 years old) and 389 females (median age was 67 years old). NLR was calculated based on results of hematology examination. Depressive symptoms were assessed using the simplified version of Geriatric Depression Scale (GDS), the participant with total score greater than five points was considered to be depressed. The association between NLR and depression was evaluated separately for men and women. The prevalence of depression was 35.1% for men and 34.4% for women. No associations were found between NLR and depression among males. Nevertheless, compared with normal women, NLR was significantly increased in women with depressive symptoms (P = 0.020). Logistic regression analysis showed that NLR was independently associated with geriatric depression in women. The odds ratios (ORs) of depression was 2.152 (1.095, 4.227; P = 0.026) for the fourth compared with the first quartile of NLR. In conclusion, this study showed increased NLR was significantly associated with geriatric depression in women, but not men.

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Section: Discussionmentioning

confidence: 99%

NLR Is Associated With Geriatric Depression in Chinese Women: A Community-Based Cross-Sectional Study in Eastern China

Liang

Zhang

et al. 2020

Front. Psychol.

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“…Patients with MDD had higher NLR as compared with healthy controls (17). Another study compared the severity of depression and cardiovascular risk factors with NLR value and found a positive correlation (18). As far as we know there has not been published any article about monocyte/lymphocyte ratio (MLR) in MDD yet.…”

Section: Introductionmentioning

confidence: 99%

Blood Cell Counts and Blood Cell Ratios as Non-Specific Major Depressive Disorder Biomarkers

Krivosova

Kusnir

Kertys

et al. 2019

Acta Medica Martiniana

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Introduction: With an increasing prevalence of major depressive disorder (MDD) in population there is a particular interest in finding a suitable biomarker for diagnosis and prognosis of the disease. Many studies have shown that MDD is linked to a systemic inflammatory process, so blood elements counts and ratios have been suggested to be promising indicators in the management and effectiveness of the disease therapy. The aim of this retrospective study was to compare absolute and relative white blood cells counts and to search for any changes in their ratios before and after the therapy of the patients. Methods: Our study included 36 patients who were admitted to hospital with either a new diagnosis or a recurrent episode of MDD and who were treated by a standard protocol. The peripheral blood samples were collected both at admission and at hospital discharge. Absolute white blood cell count and counts of neutrophils, lymphocytes, monocytes, platelets, as well as mean platelet volume, red blood cell distribution width, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and monocyte/lymphocyte ratio before and after hospitalization (14–29 days) were evaluated and compared. The test of normality was performed and, accordingly, single t-test or Mann-Whitney U-test was used for data analysis. Results: There were no significant differences between any blood cell ratios in blood samples before and after stay in hospital and appropriate treatment. Monocyte count was significantly higher in MDD patients after hospital discharge (p=0.007), there was a significantly higher difference in discharged patients suffering from MDD recurrent episode (F.33) compared to newly diagnosed MDD (F.32) patients (p=0.010). In patients treated with venlafaxine (N=23) there was a significant increase in monocyte/lymphocyte ratio observed at the end of hospitalization (p=0.018). Conclusions: The pharmacotherapy and additive treatment of the patients suffering from MDD led only to mild changes in blood cells counts. As our study included only a small number of patients, and blood cell parameters and ratios were compared after a relatively short duration of treatment, further and more detailed research is needed for final conclusions.

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“…One study reports that the increased neutrophil/lymphocyte ratio is correlated with the severity of depression in patients with depression [18]. As one of the important indicator of inflammation, neutrophilic granulocyte percentage is cheap and simple test contained in blood routine test.…”

Section: Introductionmentioning

confidence: 99%

Association between neutrophilic granulocyte percentage and depression in hospitalized patients with heart failure

Pan

Liu

et al. 2016

BMC Psychiatry

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BackgroundPrevious researches reveal that depression is associated with increased inflammatory markers. As a simple and cheap inflammatory marker, we hypothesize that neutrophilic granulocyte percentage is associated with depression in hospitalized heart failure patients, whose prevalence of depression is at a very high level.MethodsThree hundred sixty-six cases of hospitalized heart failure patients with left ventricular ejection fraction (LVEF) ≤45% and New York Heart Association (NYHA) class II-IV were enrolled. All the enrolled patients received Hamilton Rating Scale for Depression (24-items) (HAM-D24). The demographic, clinical data, blood samples and echocardiography were documented. The Pearson simple linear correlation was performed to evaluate the confounding factors correlated with HAM-D24 depression index. The significantly correlated factors were enrolled as independent variables in Logistic regression to determine the risk or protective factors for depression, which was taken as dependent variable.ResultsTwo hundred ten cases of hospitalized heart failure patients (57.4%) had depression. Among them, 134 patients (63.8%) had mild depression, 58 patients (27.6%) had moderate depression and 18 patients (8.6%) had severe depression. Pearson simple linear correlation revealed that in hospitalized patients with heart failure, the neutrophils granulocyte percentage was positively correlated with the HAM-D24 depression index (r = .435, p < .001). After the adjustment of age, BMI, number of members of the household, smoking index, New York Heart Association (NYHA) classification, hemoglobin, TC, LDL-C, creatinine, cystatin-C, TBIL and albumin, the neutrophils granulocyte percentage is still significantly associated with depression in hospitalized heart failure patients (OR = 1.046, p < .001).ConclusionsThe neutrophils granulocyte percentage may be used as a new marker for depression in hospitalized heart failure patients.

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Increased Neutrophil/Lymphocyte Ratio in Patients with Depression is Correlated with the Severity of Depression and Cardiovascular Risk Factors

Cited by 99 publications

References 28 publications

NLR Is Associated With Geriatric Depression in Chinese Women: A Community-Based Cross-Sectional Study in Eastern China

NLR Is Associated With Geriatric Depression in Chinese Women: A Community-Based Cross-Sectional Study in Eastern China

Blood Cell Counts and Blood Cell Ratios as Non-Specific Major Depressive Disorder Biomarkers

Association between neutrophilic granulocyte percentage and depression in hospitalized patients with heart failure

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