Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma

Gui, Xianyong; Guzman, Grace; Dobner, Paul R.; Kadkol, Shrihari S.

doi:10.1016/j.peptides.2008.04.014

Cited by 44 publications

(46 citation statements)

References 30 publications

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“…[1][2][3][4][5] Our previous findings 19 revealed a unique biophysical mechanism that has the potential to yield a more selective targeting approach for NTSR-1 mediated oncogenesis. We specifically demonstrated that NTS-stimulated NTSR-1 preferentially localizes within SMDs, to interact with Gα q/11 subunits.…”

Section: Discussionmentioning

confidence: 99%

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Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

Heakal

Woll

Fox

et al. 2011

Cancer Biology & Therapy

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Section: Discussionmentioning

confidence: 99%

“…The overexpression of the G-protein coupled neurotensin receptor, NTSR-1, and its endogenous ligand, NTS, plays a key role in the development and progression of several types of tumors including breast, 1 pancreas, 2 prostate, 3 colon 4 and lung 5 cancers. In invasive ductal breast carcinomas, NTS expression is regulated by estrogen.…”

Section: Introductionmentioning

confidence: 99%

Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

Heakal

Woll

Fox

et al. 2011

Cancer Biology & Therapy

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“…In vitro, neurotensin agonists have been shown to promote cellular invasion, migration, and induction of interleukin 8 and matrix metalloproteinase 1 transcripts (43). NTSR 1 is also overexpressed in colorectal carcinoma (44). GRPR and NTSR 1 are both expressed in gastrointestinal stromal tumors.…”

Section: Other Tumorsmentioning

confidence: 99%

Targeting Neuropeptide Receptors for Cancer Imaging and Therapy: Perspectives with Bombesin, Neurotensin, and Neuropeptide-Y Receptors

et al. 2014

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Learning Objectives: On successful completion of this activity, participants should be able to list and discuss (1) the presence of bombesin receptors, neurotensin receptors, or neuropeptide-Y receptors in some major tumors; (2) the perspectives offered by radiolabeled peptides targeting these receptors for imaging and therapy; and (3) the choice between agonists and antagonists for tumor targeting and the relevance of various PET radionuclides for molecular imaging.Financial Disclosure: The authors of this article have indicated no relevant relationships that could be perceived as a real or apparent conflict of interest. CME Credit: SNMMI is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing education for physicians. SNMMI designates each JNM continuing education article for a maximum of 2.0 AMA PRA Category 1 Credits. Physicians should claim only credit commensurate with the extent of their participation in the activity. For CE credit, SAM, and other credit types, participants can access this activity through the SNMMI website (http://www.snmmilearningcenter.org) through October 2017.Receptors for some regulatory peptides are highly expressed in tumors. Selective radiolabeled peptides can bind with high affinity and specificity to these receptors and exhibit favorable pharmacologic and pharmacokinetic properties, making them suitable agents for imaging or targeted therapy. The success encountered with radiolabeled somatostatin analogs is probably the first of a long list, as multiple peptide receptors are now recognized as potential targets. This review focuses on 3 neuropeptide receptor systems (bombesin, neurotensin, and neuropeptide-Y) that offer high potential in the field of nuclear oncology. The underlying biology of these peptide/receptor systems, their physiologic and pathologic roles, and their differential distribution in normal and tumoral tissues are described with emphasis on breast, prostate, and lung cancers. Radiolabeled analogs that selectively target these receptors are highlighted.

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“…NTSR1 is associated with human cell proliferation (Massa et al, 2011), promotes tumor development in mouse colon cancer model (Bugni et al, 2012) and is overexpressed in colorectal cancer progression (Gui et al, 2008). NTSR1 activates miR-21 and miR-155, via Akt and NFkB, to down-regulate PTEN and SOCS1 and promote growth of tumors in mice.…”

Section: Colorectal Cancermentioning

confidence: 99%

NTSR1 (neurotensin receptor 1 (high affinity))

Saada¹,

Marget²,

Abacci³

et al. 2017

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma

Cited by 44 publications

References 30 publications

Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

Targeting Neuropeptide Receptors for Cancer Imaging and Therapy: Perspectives with Bombesin, Neurotensin, and Neuropeptide-Y Receptors

NTSR1 (neurotensin receptor 1 (high affinity))

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