Increased mortality among individuals with chronic widespread pain relates to lifestyle factors: A prospective population-based study

Andersson, Heléne

doi:10.3109/09638280902874154

Cited by 84 publications

(108 citation statements)

References 33 publications

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“…They have included WP according to the definition within the American College of Rheumatology (ACR) criteria (1990) for FM,1 3 and modifications of the ACR 1990 FM criteria in terms of pain timing and distribution12 15 or bespoke definitions to capture ‘widespreadness’ 14. The comparison populations also differ: persons who are free of pain,1 3 14 free of chronic pain15 or who simply do not meet the phenotype12 are variously used. Some studies had an additional criterion that WP is required to be chronic, although studies of WP have shown that the vast majority of persons with WP report chronic symptoms (81% in UK Biobank).…”

Section: Discussionmentioning

confidence: 99%

Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis

2017

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Section: Discussionmentioning

confidence: 99%

Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis

2017

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“…Oxidative stress is an important part in developing atherogenesis and may link uric acid to mortality. Epidemiological studies [7][8][9] have pointed out an increased mortality of unclear aetiology among individuals with widespread pain. Psychological distress has also been associated with mortality from ischemic heart disease and respiratory disorders [25].…”

Section: Discussionmentioning

confidence: 99%

“…Psychological distress has also been associated with mortality from ischemic heart disease and respiratory disorders [25]. A hypothesis to be proven is whether an unfavourable lifestyle, including psychological distress, is the link between widespread pain, increased SU and increased mortality [9].…”

Section: Discussionmentioning

confidence: 99%

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Serum uric acid predicts changes in reports of non-gouty chronic pain: a prospective study among women with inflammatory and non-inflammatory pain

Andersson

Leden²

2010

Rheumatol Int

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Widespread pain has earlier been associated with an increase in serum urate (SU). The aim of this study was to longitudinally study the relation between changes in pain reporting and the level of SU among women with chronic pain. Consecutive female patients (n = 124; aged 20-70 years), at rheumatology and rehabilitation practices, with chronic musculoskeletal pain of different origins were followed for 1 year with repeated blood samples and questionnaires. Complete data were obtained from 107 individuals. Factors that predicted an increase in pain extension during 12 months were studied in a logistic regression model. Changes in SU showed a significant correlation (r = 0.36) with changes in the number of reported pain locations. An initially high SU level (OR = 4.46), frequent use of alcohol (OR = 1.32) and a high number of pain locations (OR = 1.24) independently predicted an increase in pain extension during 12 months, whereas the use of steroids (OR = 0.21) in patients with inflammatory disorders resulted in a decreased number of reported pain locations. A relative increase in SU in combination with report of a high number of pain locations turned out to be a risk factor of increased pain extension in a cohort of women with chronic non-gouty pain followed during 1 year. The importance of SU in relation to chronic pain and its prognosis needs to be validated in larger studies.

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“…Classification of localization, spreading, and intensity of pain Localization and intensity of pain were assessed by a validated screening questionnaire [16]. In detail, pain spreading was determined for five pain zones (neck, shoulders/arms, upper back region, lower back region, and legs) and three classes of pain spreading were defined: no spreading (0 zones), limited spreading (1-2 zones), and wide spreading (3-5 zones).…”

Section: Classification Of Rls/wed Symptomsmentioning

confidence: 99%

Chronic pulmonary disease is associated with pain spreading and restless legs syndrome in middle-aged women—a population-based study

et al. 2018

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Introduction Recent studies suggest an increased prevalence of chronic pain conditions and restless legs syndrome (RLS) in patients with chronic pulmonary disease (CPD). We analyzed the prevalence and risk factors for pain and RLS in a populationbased sample of females with comorbid CPD. Method Questionnaire-based data from 2745 women aged 18-64 years were analyzed regarding comorbid CPD status (severe bronchitis, emphysema, asthma). Pain status was assessed according to symptoms reflecting severity (Visual Analogue Scale, VAS rating 0-10) and duration and spreading (limited spread or widespread) of pain. A diagnosis of RLS was defined by four validated diagnostic criteria. Anthropometrics and co-morbidities were assessed as covariates in univariate and multivariate analyses. Results Widespread pain was overrepresented in women with CPD (44.6 vs. 24.6%, p < 0.001). The odds ratio for widespread pain in women with CPD was 1.6 (95% confidence interval (CI) 1.2-2.2, p < 0.001) in the fully adjusted model. Severe pain (VAS rating ≥ 7) was more prevalent in females with known CPD (28.8 vs. 15.4%, p < 0.001, odd ratio 1.4 (95% CI 1.0-1.9, p = 0.029)). The prevalence of RLS was 37.4 and 23.8% in subjects with or without CPD, respectively (p < 0.001). In multivariate analysis, CPD was associated with a 30% risk increase for RLS (odds ratio 1.3 (95% CI 1.0-1.7, p = 0.04)). Conclusion This population-based study identified CPD as an independent risk factor for severe and widespread pain as well as for RLS. Further research addressing pathophysiological mechanisms linking CPD and chronic pain conditions/ RLS is warranted.

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Increased mortality among individuals with chronic widespread pain relates to lifestyle factors: A prospective population-based study

Cited by 84 publications

References 33 publications

Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis

Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis

Serum uric acid predicts changes in reports of non-gouty chronic pain: a prospective study among women with inflammatory and non-inflammatory pain

Chronic pulmonary disease is associated with pain spreading and restless legs syndrome in middle-aged women—a population-based study

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