Increased mortality after liver transplantation for hepatocellular carcinoma in hepatitis B-associated cirrhosis

Jonas, Sven; Steinmüller, Thomas; Tullius, Stefan G.; Thelen, Armin; Settmacher, Utz; Berg, Thomas; Radtke, Cornelia

doi:10.1111/j.1432-2277.2003.tb00220.x

Cited by 3 publications

(1 citation statement)

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“…Die 1-und 5-Jahres-Überlebensraten sind unter Immunglobulin-Gabe und antiviraler Medikation vergleichbar mit den Resultaten anderer Indikationen [1]. Schlechtere Ergebnisse ergeben sich durch ein zusätzliches HCC [26] oder HbeAg-Positivität. Koinfektionen mit HCV und HDV weisen bessere Überlebensraten auf [64].…”

Section: Indikationen Und Ergebnisseunclassified

Lebertransplantation in Deutschland

Wolff

Kalff²,

Schwarz³

et al. 2003

Zentralbl Chir

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As in other western countries the major challenge of liver transplantation in Germany is to expand the number of liver transplantations in respect to the increasing disparity of qualified patients on the waiting list and the still static availability of brain death donor organs. The problem of death on the waiting list has become overt since the German transplantation law has been installed, which has changed the former center-oriented to a patient-oriented allocation weighting waiting time over medical urgency criteria. The more liberal acceptance of so called marginal cadaveric donor livers will probably impair further improvements in the acute and long-term outcome of liver transplantation. This problem can be partially compensated by the use of novel surgical techniques, such as splitting a donor liver to be transplanted into two adult recipients or, more commonly and safe, into an adult and one child. Another alternative to increase the donor pool is living donor liver transplantation, which was first introduced for pediatric recipients but is now increasingly used in adults. In 2001, a constant number of 757 liver transplantations were performed in Germany, including 12.5 % living donor transplantations. Recently, general guidelines for the selection of patients with end-stage liver disease and acute liver failure have been published by the Bundesärztekammer. Additional developments have contributed to improve the results of liver replacement including individualized immunosuppression strategies and novel treatment options to avoid recurrent viral disease following transplantation.

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Section: Indikationen Und Ergebnisseunclassified