Increased monocyte to HDL cholesterol ratio in vitamin B12 deficiency: Is it related to cardiometabolic risk?

Abstract

<jats:p> Abstract. Vitamin B12 deficiency may have indirect cardiovascular effects in addition to hematological and neuropsychiatric symptoms. It was shown that the monocyte count-to-high density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel cardiovascular marker. In this study, the aim was to evaluate whether MHR was high in patients with vitamin B12 deficiency and its relationship with cardiometabolic risk factors. The study included 128 patients diagnosed with vitamin B12 deficiency and 93 healthy controls. Patients with vitamin B12 deficiency had significantly higher systolic blood pressure (SBP), diastolic blood pressure (DBP), MHR, C-reactive protein (CRP) and uric acid levels compared with the controls (median 139 vs 115 mmHg, p &lt; 0.001; 80 vs 70 mmHg, p &lt; 0.001; 14.2 vs 9.5, p &lt; 0.001; 10.2 vs 4 mg/dl p &lt; 0.001; 6.68 vs 4.8 mg/dl, p &lt; 0.001 respectively). The prevalence of left ventricular hypertrophy was higher in vitamin B12 deficiency group (43.8%) than the control group (8.6%) (p &lt; 0.001). In vitamin B12 deficiency group, a positive correlation was detected between MHR and SBP, CRP and uric acid (p &lt; 0.001 r:0.34, p &lt; 0.001 r:0.30, p &lt; 0.001 r:0.5, respectively) and a significant negative correlation was detected between MHR and T-CHOL, LDL, HDL and B12 (p &lt; 0.001 r: −0.39, p &lt; 0.001 r: −0.34, p &lt; 0.001 r: −0.57, p &lt; 0.04 r: −0.17, respectively). MHR was high in vitamin B12 deficiency group, and correlated with the cardiometabolic risk factors in this group, which were SBP, CRP, uric acid and HDL. In conclusion, MRH, which can be easily calculated in clinical practice, can be a useful marker to assess cardiovascular risk in patients with vitamin B12 deficiency. </jats:p>

Endothelium-derived Microparticles Are Increased in Teenagers With Cobalamin Deficiency

“…Kayhan et al19 reported monocyte count-to-HDL cholesterol ratio was high in the vitamin B 12 deficiency group and correlated with the cardiometabolic risk factors. Adaikalakoteswari and colleagues showed in 91 mother-infant pairs that low maternal B 12 level is independently associated with adverse cord blood cholesterol.…”

CONSUMPTION OF Hibiscus sabdariffa DRIED CALYX ETHANOL EXTRACT IMPROVED REDOX IMBALANCE AND GLUCOSE PLASMA IN VITAMIN B12 RESTRICTION DIET IN RATS

“…Homocysteine is a key component in the methionine metabolism involving vitamin B12 (Kayhan et al, 2020). The intracellular build-up of homocysteine occurs when methionine metabolism is impeded due to vitamin B12 deficiency, resulting in the rise in plasma homocysteine levels.…”