Increased Mobility of Major Histocompatibility Complex I-Peptide Complexes Decreases the Sensitivity of Antigen Recognition

Segura, Jean-Manuel; Guillaume, Philippe; Mark, Silke; Dojcinovic, Danijel; Johannsen, Alexandre; Bosshard, Giovanna; Angelov, Georgi S.; Legler, Daniel F.; Vogel, Horst; Luescher, Immanuel F.

doi:10.1074/jbc.m803549200

Cited by 21 publications

(26 citation statements)

References 49 publications

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“…1). While the formation of nascent synapse was seen in experiments with supported bilayers bearing soluble analogs of MHC-I and ICAM-1 molecules, a very similar structure of the interface was also observed for CD8 + CTL interacting with live target cells (77). …”

Section: The Role Of the Cytolytic Synapsementioning

confidence: 70%

Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes

Anikeeva

Sykulev

2011

Immunol Res

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Cytotoxic T lymphocytes (CTL) play a critical role in the immunity against viruses and cancer. The antigen receptor or T-cell receptor (TCR) on CTL determines the specificity of unwanted cell targeting. The CD8 co-receptor functions in concert with the TCR to enhance TCR-mediated signaling, accounting for the remarkable sensitivity and swift signaling kinetics of the CTL response. The latter ensures efficient delivery of lytic granules to target cells, resulting in their sensitive and rapid destruction.

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Section: The Role Of the Cytolytic Synapsementioning

confidence: 70%

Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes

Anikeeva

Sykulev

2011

Immunol Res

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“…This increases the probability of successful granule penetration into a target cell and the induction of target cell death. Thus, even though a mature cytolytic synapse is not required for cytolytic activity (41,42), the formation of a very well structured synaptic interface is essential for efficient cytolytic granule delivery and target cell destruction (6).…”

Section: Discussionmentioning

confidence: 99%

Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner

Steblyanko

Anikeeva

Campbell

et al. 2015

Journal of Biological Chemistry

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Background:The mechanism by which integrin signaling regulates lymphocyte cytolytic activity is poorly understood. Results: The extent of integrin ligation influences the size and dynamics of signaling microclusters. Conclusion: Integrins regulate the magnitude and duration of proximal signaling that affect lymphocyte degranulation kinetics and the rate of target cell lysis. Significance: Integrin engagement ensures more rapid cytolytic granule release and faster target cell destruction.

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“…The mechanism by which this works is that adhesion leads to a transient increase in cyclic AMP, which in turn leads to Erk activation, sensitizing the T cell for the monomeric MHC–peptide stimulation (Conche et al 2009). Immobilization of MHC–peptide has also been shown to occur as a result of an interaction between MHC class I molecules and ICAM1, causing concentration of both antigenic and nonstimulatory MHC class I–peptide complexes in the immunological synapse, and leading to increased T cell activation (Segura et al 2008). These data suggest that part of the role of the nonstimulatory MHC–peptide complexes is to aid in the cell adhesion, which in turn aids the priming of the T cells.…”

Section: Differing Co-receptor Roles In Recognition Of Endogenous Mmentioning

confidence: 99%

Co-Receptors and Recognition of Self at the Immunological Synapse

Gascoigne

Żal

Yachi

et al. 2009

Current Topics in Microbiology and Immunology

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The co-receptors CD4 and CD8 are important in the activation of T cells, primarily because of their ability to interact with the proteins of the MHC, enhancing recognition of the MHC–peptide complex by the T cell receptor (TCR). An antigen-presenting cell presents a small number of antigenic peptides on its MHC molecules, in the presence of a much larger number of endogenous, mostly nonstimulatory, peptides. Recent work has demonstrated that these endogenous MHC–peptide complexes have an important role in modulating the sensitivity of the TCR. But the role of the endogenous nonstimulatory MHC–peptide complexes differs in MHC class I and class II-restricted T cells. This chapter discusses the data on the role of CD4 or CD8 co-receptors in T cell activation at the immunological synapse, and the role of non stimulatory MHC–peptide complexes in aiding antigen recognition.

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Increased Mobility of Major Histocompatibility Complex I-Peptide Complexes Decreases the Sensitivity of Antigen Recognition

Abstract: CD8؉ cytotoxic T lymphocytes (CTL) can recognize and kill target cells expressing only a few cognate major histocompatibility complex (

Cited by 21 publications

References 49 publications

Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes

Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes

Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner

Co-Receptors and Recognition of Self at the Immunological Synapse

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