“…Among them, calcium signaling plays an important role in ROS generation, and calcium signaling dysregulation is an important contributor to neuronal pathology. Specifically, elevated intracellular calcium concentration has been associated with increased oxidative stress in AD models [26,63,64]. fAD, which is caused predominantly by mutations in the presenilin encoding genes, is also associated with altered calcium signaling (Cheung et al, 2008;Chan et al, 2000;Lee et al, 2006;Stutzmann et al, 2004) [7,8,11,12].…”