Increased micronucleus frequencies in reticulocytes of children exposed to industrial pollution: oxidative stress and the OGG1 S326C polymorphism

Montero‐Montoya, Regina; López-Vargas, Rocío; Méndez-Serrano, Alejandra; Galicia-Alonso, Isaías; García-Vargas, Guadalupe; Serrano-García, Luis; Beltrán-Portugal, Rosa; Rosado-Zaidi, Samuel; Albores-Medina, Arnulfo; Oropeza-Hernández, Luis F.; Hernández‐Cadena, Leticia; Mercado-Calderón, Francisco; Alvarado-Toledo, Esmeralda; Herrera-Morales, Selene; Arellano-Aguilar, Omar

doi:10.1016/j.mrgentox.2020.503170

Cited by 7 publications

(3 citation statements)

References 32 publications

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“…A first level of regulation comes from the numerous tumor-associated variants of DNA glycosylases that have been described (reviewed in [119]), which strongly argue for a genetic linkage between DNA glycosylases and cancer [120]. For instance, the S326C polymorphic variant of OGG1, which is widespread in Caucasian and Asian populations, has been reported to be associated with different types of cancers [121][122][123][124]. Interestingly, this variant has been shown to have reduced DNA glycosylase activity and is more sensitive to oxidation [41,125,126].…”

Section: Regulation Of Dna Glycosylasesmentioning

confidence: 99%

Focus on DNA Glycosylases—A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets

Hans

Senarisoy

Naidu

et al. 2020

IJMS

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Cancer is the second leading cause of death with tens of millions of people diagnosed with cancer every year around the world. Most radio- and chemotherapies aim to eliminate cancer cells, notably by causing severe damage to the DNA. However, efficient repair of such damage represents a common mechanism of resistance to initially effective cytotoxic agents. Thus, development of new generation anticancer drugs that target DNA repair pathways, and more particularly the base excision repair (BER) pathway that is responsible for removal of damaged bases, is of growing interest. The BER pathway is initiated by a set of enzymes known as DNA glycosylases. Unlike several downstream BER enzymes, DNA glycosylases have so far received little attention and the development of specific inhibitors of these enzymes has been lagging. Yet, dysregulation of DNA glycosylases is also known to play a central role in numerous cancers and at different stages of the disease, and thus inhibiting DNA glycosylases is now considered a valid strategy to eliminate cancer cells. This review provides a detailed overview of the activities of DNA glycosylases in normal and cancer cells, their modes of regulation, and their potential as anticancer drug targets.

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Section: Regulation Of Dna Glycosylasesmentioning

confidence: 99%

Focus on DNA Glycosylases—A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets

Hans

Senarisoy

Naidu

et al. 2020

IJMS

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“…Few studies have been conducted globally to determine the cytotoxic potential of complex mixtures of toxic metals (TM) and volatile organic compounds (VOCs) in aquatic ecosystems such as rivers [8,9], and most have focused on evaluating the cytotoxic effects of mixtures of TM and VOCs in occupational [10,11] and urban environments [12]. erefore, there is a need to conduct cytotoxic assessment studies using biomodels that explain the short-and longterm health risks of organisms exposed to aquatic environments influenced by contaminant mixtures of TM and VOCs that are potentially carcinogenic.…”

Section: Introductionmentioning

confidence: 99%

Mixture of Toxic Metals and Volatile Organic Compounds in a River Induces Cytotoxicity

Estrada

García

Chávez

et al. 2022

Journal of Chemistry

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Pollution of aquatic ecosystems due to toxic mixtures is a worldwide problem associated with the increase of wastewater discharges that causes problems to human health and biodiversity. This study aims to evaluate the cytotoxic potential of water from the Atoyac River. Meristems of Allium cepa L. were exposed to water samples from the Atoyac River with different concentrations for 120 hours. Pearson correlation was used to investigate the relationship between contaminants and cytotoxicity. The results corroborated the cytotoxic effect of the mixture of agents such as toxic metals and volatile organic compounds found in all river sampling sites. The Allium cepa test showed decreased mitotic alterations in prophase and metaphase indices. There was a strong negative association between the concentration of toxic metals and volatile organic compounds and the cytotoxic effect. The observations of cytotoxic effects show that the contaminant mixture contains aneugenic agents which prevent the synthesis and fixation of fibers of the mitotic spindle to the kinetochore, which prevents the displacement of the chromosomes. This study shows the need to study the effects at the cellular and molecular level in heavily polluted rivers to prevent negative effects on exposed ecosystems and populations.

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“…It is a sensitive high-throughput method with high potential in biomonitoring studies [35]. The method has been previously used for studying the potential genotoxicity of pesticides [36], disinfection by-products [37], industrial pollution [38], and polycyclic aromatic hydrocarbons (PAHs) [39]. As application of flow cytometry allows for the rapid analysis of large amounts of cells, the method also has benefits compared to microscopically analyzed endpoints which suffer from the limited number of reasonably countable cells and potential individual differences in analyzing cells [40].…”

Section: Introductionmentioning

confidence: 99%

HBM4EU Chromates Study—Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium

Tavares

Aimonen

Ndaw

et al. 2022

Toxics

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A study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes and reticulocytes, the comet assay in whole blood, and malondialdehyde and 8-oxo-2′-deoxyguanosine in urine. Workers from several Cr(VI)-related industrial activities and controls from industrial (within company) and non-industrial (outwith company) environments were included. The significantly increased genotoxicity (p = 0.03 for MN in lymphocytes and reticulocytes; p < 0.001 for comet assay data) and oxidative stress levels (p = 0.007 and p < 0.001 for MDA and 8-OHdG levels in pre-shift urine samples, respectively) that were detected in the exposed workers over the outwith company controls suggest that Cr(VI) exposure might still represent a health risk, particularly, for chrome painters and electrolytic bath platers, despite the low Cr exposure. The within-company controls displayed DNA and chromosomal damage levels that were comparable to those of the exposed group, highlighting the relevance of considering all industry workers as potentially exposed. The use of effect biomarkers proved their capacity to detect the early biological effects from low Cr(VI) exposure, and to contribute to identifying subgroups that are at higher risk. Overall, this study reinforces the need for further re-evaluation of the occupational exposure limit and better application of protection measures. However, it also raised some additional questions and unexplained inconsistencies that need follow-up studies to be clarified.

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Increased micronucleus frequencies in reticulocytes of children exposed to industrial pollution: oxidative stress and the OGG1 S326C polymorphism

Cited by 7 publications

References 32 publications

Focus on DNA Glycosylases—A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets

Focus on DNA Glycosylases—A Set of Tightly Regulated Enzymes with a High Potential as Anticancer Drug Targets

Mixture of Toxic Metals and Volatile Organic Compounds in a River Induces Cytotoxicity

HBM4EU Chromates Study—Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium

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