Increased Micronuclei Frequency in Oral and Lingual Epithelium of Treated Diabetes Mellitus Patients

Ojeda, Jesús Emilo Quintero; Aguilar‐Medina, Maribel; Olimón-Andalón, Vicente; Jau, Rosa Alicia García; Ham, Alfredo Ayala; Quintana, José Geovanni Romero; Silva-Benítez, Erika de Lourdes; Sánchez-Schmitz, Guzman; Ramos‐Payán, Rosalío

doi:10.1155/2018/4898153

Cited by 15 publications

(3 citation statements)

References 40 publications

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“…Nevertheless, our study quite clearly indicated that the frequency of both CTAs and CSAs depends on the duration of the disease, not the type of diabetes. Interestingly, the same type of association has been reported in one CA [ 28 ] and several MN studies in T2DM patients [ 33 , 34 , 35 ]. Conversely, other studies failed to find a correlation between the frequency of MN and disease duration in T2DM [ 36 , 37 ].…”

Section: Discussionsupporting

confidence: 73%

“…Conversely, other studies failed to find a correlation between the frequency of MN and disease duration in T2DM [ 36 , 37 ]. No correlation between the frequency of MN and duration of T1DM was found [ 35 , 38 ]. It is worth noting that the average diabetes duration in these studies was significantly shorter than ours, with an average disease duration of 13 years for both types.…”

Section: Discussionmentioning

confidence: 99%

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Influence of Body Mass Index and Duration of Disease on Chromosome Damage in Lymphocytes of Patients with Diabetes

Šiaulienė,

Kazlauskaitė,

Jurkėnaitė

et al. 2023

Life

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It is well-established that patients with diabetes mellitus (DM) have a higher incidence of several types of cancer. The precise mechanisms of this association are still unknown, but obesity and chronic inflammation-induced reactive oxygen species (ROS) are thought to be the main risk factors. ROS may produce different DNA damage, which could eventually lead to cancer. The main objective of this study was to evaluate the relation of chromosome aberrations (CA) with disease status, demographics, and clinical parameters in 33 subjects with type 1 DM (T1DM), 22 subjects with type 2 DM (T2DM), and 21 controls. CAs were analyzed in cultured peripheral blood lymphocytes and subdivided into chromatid (CTA)- and chromosome (CSA)-type aberrations. Compared with controls, higher levels of CTAs and CSAs were observed in T1DM (p = 0.0053 and p = 0.0203, respectively) and T2DM (p = 0.0133 and p = 0.00002, respectively). While there was no difference in CTAs between T1DM and T2DM, CSAs were higher in T2DM (p = 0.0173). A significant positive association between CTAs and disease duration (rs = 0.2938, p = 0.0099) and between CSAs and disease duration (rs = 0.4306, p = 0.0001), age (rs = 0.3932, p = 0.0004), and body mass index (BMI) (rs = 0.3502, p = 0.0019) was revealed. After multiple regression analysis, duration of disease remained significant for CTA, CSA, and CAs (p = 0.0042, p = 0.00003, and p = 0.00002, respectively). For CSA, BMI and the use of statins were the other important confounding variables (p = 0.0105 and p = 0.0763). Thus, this study demonstrated that both T1DM and T2DM patients had a higher number of all types of aberrations than controls, which increases with the prolonged disease duration. Higher BMI was associated with a higher frequency of CSA. The use of statins might be beneficial for reducing chromosome damage, but further investigations are needed to confirm this association.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Influence of Body Mass Index and Duration of Disease on Chromosome Damage in Lymphocytes of Patients with Diabetes

Šiaulienė,

Kazlauskaitė,

Jurkėnaitė

et al. 2023

Life

View full text Add to dashboard Cite

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“…Systolic pressure more than 140 mmHg or diastolic pressure more than 90 mmHg [46]. In many studies conducted on garlic it is demonstrated to have antihypertensive activity which makes it one of the top studied functional food [14,56]. Garlic help in lowering both systolic as well as diastolic blood pressure as described by Reinhart [56].…”

Section: How Garlic Is Antihypertensive?mentioning

confidence: 99%

Advancement and Future Directions towards Herbal Treatment for Various Diseases

Ghani¹,

Batool²,

Rafeeq³

et al. 2019

SJMPS

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The purpose of review article is to find herbal drug for treatment of some diseases. Several side effects came from chemical drugs. Use of non-chemical, non-invasive natural remedies have no major adverse effect because contain naturally active biological components, therefore they have paying much attention within recent years. Possible usage of leaf extract of Papaya for treatment of dengue fever promising cure for dengue patients. Pomegranate contains high level of antioxidants which make it one of the best fruits for boosting blood count. Phenolic compound extraction from extra virgin olive oil has immune modulatory and anti-inflammatory effects in Systemic lupus erythematosus (SLE) patients. Wound healing properties are exerted from aloe Vera gel. Fenugreek seed best natural remedy for Poly ovarian cyst syndrome (POCS). Garlic and ginger are organosulfur compounds consisting upon its bio actives having an important role in cardiovascular diseases and cancer respectively.Nigella sativa recently demonstrates the role in diabetes mellitus. Allium cepa. L (Onion) contain phytochemicals that have antidiabetic, anticarcinogenic, anti-inflammatory, antibiotic, antioxidant, antimicrobial and antiplatelet effects on the human health.

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Is micronucleus assay a useful marker in gingiva, tongue, and palate for evaluating cytogenetic damage induced by chemical, physical, and biological agents in vivo? A systematic review with meta‐analysis

Pinto,

Takeshita,

Renno

et al. 2024

J of Applied Toxicology

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The present systematic review (SR) aims to evaluate manuscripts in order to help further elucidate the following question: is the micronucleus assay (MA) also a useful marker in gingiva, tongue, and palate for evaluating cytogenetic damage in vivo? A search was performed through the electronic databases PubMed/Medline, Scopus, and Web of Science, all studies published up to December 2023. The comparisons were defined as standardized mean difference (SMD), and 95% confidence intervals (CIs) were established. Full manuscripts from 34 studies were carefully selected and reviewed in this setting. Our results demonstrate that the MA may be a useful biomarker of gingival tissue damage in vivo, and this tissue could be a useful alternative to the buccal mucosa. The meta‐analysis analyzing the different sites regardless of the deleterious factor studied, the buccal mucosa (SMD = 0.69, 95% CI, − 0.49 to 1.88, p = 0.25) and gingiva (SMD = 0.31, 95% CI, − 0.11 to 0.72, p = 0.15), showed similar results and different outcome for the tongue (SMD = 1.19, 95% CI, 0.47 to 1.91, p = 0.001). In summary, our conclusion suggests that the MA can be a useful marker for detecting DNA damage in gingiva in vivo and that this tissue could be effective site for smearing.

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Increased Micronuclei Frequency in Oral and Lingual Epithelium of Treated Diabetes Mellitus Patients

Cited by 15 publications

References 40 publications

Influence of Body Mass Index and Duration of Disease on Chromosome Damage in Lymphocytes of Patients with Diabetes

Influence of Body Mass Index and Duration of Disease on Chromosome Damage in Lymphocytes of Patients with Diabetes

Advancement and Future Directions towards Herbal Treatment for Various Diseases

Is micronucleus assay a useful marker in gingiva, tongue, and palate for evaluating cytogenetic damage induced by chemical, physical, and biological agents in vivo? A systematic review with meta‐analysis

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