Increased Micro<scp>RNA</scp>‐1266 levels as a biomarker for disease activity in psoriasis vulgaris

Seifeldin, Neveen S.; Sayed, Shereen Bendary El; Asaad, Marwa K.

doi:10.1111/ijd.13102

Cited by 15 publications

(7 citation statements)

References 37 publications

(53 reference statements)

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“…One of the most important findings in this work is the positive correlation between PB IFN- γ + Th17 cells and the PASI score, which indicates that these cells are associated with the severity. In psoriasis, the existence of biomarkers associated with severity, such as IL-36 γ , Squamous Cell Carcinoma Antigen 2 (SCCA2), and miRNA1266, has been reported [ 56 – 58 ]. To our knowledge, this is the first report of a Th17 cells subset associated to the severity of psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients

Aguilar-Flores

Castro-Escamilla

Ortega-Rocha

et al. 2020

Mediators of Inflammation

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Psoriasis is an inflammatory autoimmune disease characterized by cutaneous lesions in plaques. It has been proposed that the immune response has a key role in the disease progression. Particularly, the Th17 cells through IL-17 can contribute to maintain the inflammatory process. The pathogenic Th17 phenotype has been described in human diseases and associated with high severity in inflammatory experimental models. However, it is not clear if the pathogenic phenotype could be present in the skin and peripheral blood as well as its possible association to severity in psoriasis. In the lesional skin, we found high infiltration of Th17 cells and the pathogenic phenotype, finding a correlation between the frequency of Th17 cells and the Psoriasis Area and Severity Index (PASI) score. In peripheral blood, we observed a pool of Th17 lymphocytes with potential to acquire pathogenic features. Interestingly, the percentage of pathogenic Th17 cells (CD4+ RORγt+ IFN-γ+) correlates with disease severity. Moreover, we distinguished three groups of patients based on their IL-17/IFN-γ production by Th17 lymphocytes, which seems to be related with a dynamic or stable potential to express these cytokines. Remarkably, we evaluated the cytokine production by Th17 cells as an immunological marker for the adequate selection of biologic therapy. We found that patients analyzed by this immunological approach and treated with antibodies against IL-17 and TNFα showed great improvement depicted by reduction in PASI and Dermatology Life Quality Index (DLQI) score as well as the percentage of Body Surface Area (BSA). Altogether, our results highlight the importance of the assessment of the pathogenic phenotype in Th17 cells as an immune personalized analysis with the potential to support the therapy choice in the clinical practice.

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Section: Discussionmentioning

confidence: 99%

Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients

Aguilar-Flores

Castro-Escamilla

Ortega-Rocha

et al. 2020

Mediators of Inflammation

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“…miRNA plays an important role in posttranscriptional regulation of gene expression, participating in many important physiological processes, including development, cell differentiation, and regulation of signaling pathways [ 55 ]. The participation of these molecules is emphasized in pathological conditions, for example, in tumors [ 55 , 56 ], neurological disorders [ 56 ], and psoriasis [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…The high serum level of miR-1266 was observed in patients with psoriasis, highlighting its potential use as a biomarker [ 18 ]. In addition, the increased expression of miRNA-155, let-7i, miRNA-146a, miRNA-21, and miRNA-223 in the mononuclear cells of peripheral blood and also miRNA-21, miRNA-146a, and miRNA-223 in plasma was noted [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Adalimumab on the Expression Profile of Genes Associated with the Histaminergic System in the Skin Fibroblasts In Vitro

Wcisło‐Dziadecka

Grabarek

Zmarzły

et al. 2018

BioMed Research International

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Objective The aim of this study was to evaluate the influence of adalimumab on expression profile of genes associated with the histaminergic system in Normal Human Dermal Fibroblast (NHDF) cells stimulated with 8.00 μg/ml of adalimumab and the identification of miRNAs regulating these genes' expression. Methods NHDFs were cultured with or without the presence of adalimumab for 2, 8, and 24 hours. The expression profile of genes and miRNA were determined with the use of microarray technology. Results Among 22283 ID mRNA, 65 are associated with the histaminergic system. It can be observed that 15 mRNAs differentiate NHDFs cultures with adalimumab form control. The analysis of miRNAs showed that, among 1105 ID miRNA, 20 miRNAs are differentiating in cells treated with adalimumab for 2 hours, 9 miRNA after 8 hours, and only 3 miRNAs after 24 hours. Conclusion It was also determined that miRNAs play certain role in the regulation of the expression of genes associated with the histaminergic system. The results of this study confirmed the possibility of using both genes associated with this system as well as miRNAs regulating their expression, as complementary molecular markers of sensitivity to the adalimumab treatment.

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“…The differentially expressed miRNAs we identified do not correspond to those of other studies in psoriasis, and a possible explanation of the discrepancy is that most of the previous studies used samples such as psoriatic lesion tissues, keratinocytes, hair roots/shaft, PBMCs, psoriasis epidermal cells, and dermal T cells, but not plasma [ miR-1266 and miR-33 have been detected to be deregulated in blood samples of patients with psoriasis. miR-1266 is overexpressed in psoriasis serum samples [77], which may be differentially expressed in plasma. In addition, since miR-33 is involved in the posttranscriptional regulation of genes associated with lipid metabolism, one study reported that the plasma levels of lipid and glucose metabolismrelated miR-33 are increased and correlated with insulin in psoriasis patients [78].…”

Section: Journal Of Immunology Researchmentioning

confidence: 99%

Plasma MicroRNA Expression Profiles in Psoriasis

Xiao

Liu

Wang

et al. 2020

Journal of Immunology Research

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Background. Psoriasis is an immune-mediated inflammatory chronic skin disease characterized by chronic inflammation in the dermis, parakeratosis, and excessive epidermal growth. MicroRNAs (miRNAs) are key regulators of immune responses. Although differential expression of miRNAs has been reported in certain inflammatory autoimmune diseases, their role in psoriasis has not been fully illuminated. Our aims were to confirm plasma miRNA expression signatures in psoriasis and to examine their potential influence on psoriasis pathogenesis. Methods. A miRNome PCR array was used to analyse the plasma of psoriasis patients and healthy donors. We performed miRNA pathway enrichment and target gene network analyses on psoriasis plasma samples. Results. We found several specific plasma miRNA signatures relevant to psoriasis. The miRNAs targeted pathways associated with psoriasis, such as the VEGF, MAPK, and WNT signaling pathways. Network analysis revealed pivotal deregulated plasma miRNAs and their relevant target genes and pathways regulating psoriasis pathogenesis. Conclusions. This study analysed the expression of plasma miRNAs and their target pathways, elucidating the pathogenesis of psoriasis; these results may be used to design novel therapeutic strategies and to identify diagnostic biomarkers for psoriasis.

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Increased MicroRNA‐1266 levels as a biomarker for disease activity in psoriasis vulgaris

Abstract: miR-1266 may have an important role in the pathogenesis of psoriasis vulgaris. This may presumably have possible future implications on the treatment of this chronic disease.

Cited by 15 publications

References 37 publications

Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients

Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients

Influence of Adalimumab on the Expression Profile of Genes Associated with the Histaminergic System in the Skin Fibroblasts In Vitro

Plasma MicroRNA Expression Profiles in Psoriasis

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