Increased mechanical strength of healing rat tibial fractures treated with biosynthetic human growth hormone

Bak, Bue; Jørgensen, Peter; Andreassen, Troels T.

doi:10.1016/8756-3282(90)90075-a

Cited by 56 publications

(31 citation statements)

References 17 publications

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“…Neither could the explanation be an inadequate dose, since several positive effects were seen in muscle and bone. Moreover, a previous study has shown that Growth Hormone improves fracture healing in rats when using the current dose [4]. The remaining explanation to our results could therefore be that, for stimulation of tendon healing, pharmacological concentrations of IGF-1 are needed, and that the given Growth Hormone doses are unable to produce the required local increase in IGF-1 concentrations.…”

Section: Discussionmentioning

confidence: 62%

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Growth Hormone Does Not Stimulate Early Healing in Rat Tendons

2012

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Growth Hormone stimulates bone growth and fracture repair. It acts mainly by increasing the systemic levels of IGF-1. Local treatment with IGF-1 appears to stimulate tendon healing.We therefore hypothesized that systemic treatment with Growth Hormone would also stimulate tendon healing. Rat Achilles tendons were transected and left to heal. Four groups were studied. Intramuscular injections of botulinum toxin A (Botox) were used to reduce loading in 2 groups. The animals were randomized to twice daily injections of Growth Hormone (n = 2 x 10) or saline (n = 2 x 10), and killed after 10 days. Healing was assessed by mechanical testing. Muscle paralysis induced by Botox reduced the strength of the healing tendon by two thirds. Growth Hormone increased femoral and tibial length in the unloaded, and femoral and tibial weight in the loaded group. Body weight and muscle weight were increased in both. In contrast, there was no increase in the strength of the healing tendons, regardless of mechanical loading status. An increase in peak force of the loaded healing tendons by more than 5 % could be excluded with 95 % confidence. In spite of its stimulatory effects on other tissues, Growth Hormone did not appear to stimulate tendon or tendon repair.

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Section: Discussionmentioning

confidence: 62%

“…Several studies have shown that Growth Hormone has positive effects on fracture healing [4,17,[22][23][24]. There are, however, contradicting results, and the outcome of treatment seems to depend on model, dose, time-point and duration of administration [3,5,8].…”

Section: Introductionmentioning

confidence: 99%

Growth Hormone Does Not Stimulate Early Healing in Rat Tendons

2012

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“…In this study, all rats received subcutaneous injections of recombinant human Growth hormone (1 mg) twice per day. Significant improvement in maximal stiffness and ultimate load-bearing were observed during evaluation performed after 40 days of healing (Bak et al, 1990). Kolbeck et al studied 23 dogs with experimentally-induced 3 cm ulnar bone defects and intramedullary fixation.…”

Section: Intra-articular Injections For the Treatment Of Osteoarthritmentioning

confidence: 99%

Intra-Articular Injections for the Treatment of Osteoarthritis: Focus on the Clinical Use of Several Regimens

Kwon¹,

Park²

2012

Osteoarthritis - Diagnosis, Treatment and Surgery

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“…A few studies on accidental hip fracture patients have looked potentially promising (1-3), and there is evidence from animal models and from in vitro studies that GH stimulates fracture healing (4)(5)(6)(7)(8)(9)(10). Thus, GH may have potential as a therapeutic option in enhancement of the healing of these fractures; however, no published data from clinical trials exist.…”

Section: Introductionmentioning

confidence: 99%

Effects of growth hormone in patients with tibial fracture: a randomised, double-blind, placebo-controlled clinical trial

Raschke

Rasmussen²,

Govender³

et al. 2007

eur j endocrinol

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Objective: Investigate whether intervention with GH after tibial fracture enhances fracture healing. Design: Randomised, double-blind, placebo-controlled study in 406 patients (93 women, 313 men, age: 18-64 years) with tibial fracture. Methods: Patients were stratified by tibial fracture (open or closed) and allocated to placebo or GH treatment (15, 30 or 60 mg/kg daily, until clinically assessed healing or until 16 weeks post-surgery). Primary outcome was time from surgery until fracture healing and assessment of healing was done centrally and observer blinded. Patients reported for evaluation every 4 weeks until 24 weeks, and at 9 and 12 months.

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Increased mechanical strength of healing rat tibial fractures treated with biosynthetic human growth hormone

Cited by 56 publications

References 17 publications

Growth Hormone Does Not Stimulate Early Healing in Rat Tendons

Growth Hormone Does Not Stimulate Early Healing in Rat Tendons

Intra-Articular Injections for the Treatment of Osteoarthritis: Focus on the Clinical Use of Several Regimens

Effects of growth hormone in patients with tibial fracture: a randomised, double-blind, placebo-controlled clinical trial

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