Increased maternal serum aquaporin‐9 expression in pregnancies complicated with early‐onset preeclampsia

Abstract

Objectives We aimed to evaluate maternal serum aquaporin‐9 (AQP9) concentrations in patients with early‐onset preeclampsia and compare them with the uncomplicated control group with normal blood pressure. Methods This was a prospective case–control study including pregnant women who were diagnosed with early‐onset preeclampsia between 200/7–340/7 weeks of gestation. Demographic and clinical characteristics, complete blood count and biochemical parameters, and serum AQP9 concentrations were documented. A receiver operating characteristic (ROC) curve was constructed to illustrate the sensitivity and specificity performance characteristics of AQP9 and a cut‐off value was estimated by using the Youden index. Results The mean serum concentrations of maternal AQP9 were significantly increased in the early‐onset preeclampsia group (722.22 ± 211.80 pg/mL) than the control group (499.97 ± 68.89 pg/mL, p < 0.001). When we analyze the area under the ROC curve (AUC), the serum AQP9 value can be considered a statistically significant parameter for diagnosing preeclampsia. According to the Youden index, a 587.70 ng/mL cut‐off value of serum AQP9 level can be used to diagnose early‐onset preeclampsia with 80.0% sensitivity and 89.7% specificity. Conclusion Maternal serum AQP9 concentrations were significantly increased in early‐onset preeclampsia patients than healthy normotensive pregnant patients. We suggest that AQP9 might be a crucial biomarker of the inflammatory process in early‐onset preeclampsia.

Maternal and neonatal outcomes of expectantly managed pregnancies with previable preterm premature rupture of membranes

“…Inflammation-oxidative stress axis acts a crucial role in the pathogenesis of diverse obstetric complications, including PPROM. 16,[27][28][29][30] The prognostic value of systemic inflammatory markers, including NLR and PLR, in many diseases, such as early pregnancy loss, membrane rupture, and HCA, has already been demonstrated in several studies. 19,31,32 Ozel et al reported that high NLR values could be useful for predicting adverse neonatal outcomes in patients with PPROM.…”

The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker

“…In gestational diabetes mellitus, placentas from cesarean delivery at term showed higher expression of AQP9 compared to normal placentas [ 116 ]. In pre-eclampsia, serum AQP9 was increased in the early onset of the disease compared to healthy women [ 47 , 117 ]. The analysis of the area under the ROC curve (AUC) demonstrates that the serum AQP9 value can be considered a stable biomarker in pre-eclampsia early-onset diagnosis by depicting the inflammatory state of the patient [ 117 ].…”

“…In pre-eclampsia, serum AQP9 was increased in the early onset of the disease compared to healthy women [ 47 , 117 ]. The analysis of the area under the ROC curve (AUC) demonstrates that the serum AQP9 value can be considered a stable biomarker in pre-eclampsia early-onset diagnosis by depicting the inflammatory state of the patient [ 117 ]. In tubal ectopic pregnancy patients, the fallopian tubes showed lower expression levels of AQP9 than in healthy subjects [ 71 ].…”

The evaluation of the antepartum and intrapartum risk factors in predicting the risk of birth asphyxia

“…Advanced maternal age was diagnosed as pregnant women being 35 years or older at the delivery time 19 . Preeclampsia was identified as maternal hypertension >140/90 mmHg without a previous history of hypertension and 300 mg/L proteinuria without a history of renal disease 20,21 . GDM was diagnosed with a 75‐g oral glucose tolerance test (OGTT) between 24–28 weeks of gestation.…”

“…19 Preeclampsia was identified as maternal hypertension >140/90 mmHg without a previous history of hypertension and 300 mg/L proteinuria without a history of renal disease. 20,21 GDM was diagnosed with a 75-g oral glucose tolerance test (OGTT) between 24-28 weeks of gestation. The threshold values for fasting, 1-h, and 2-h plasma glucose concentrations were 92 mg/dL, 180 mg/dL, and 153 mg/dL, respectively.…”