Increased mast cell density and protease content in actinic cheilitis

Rojas, Isolde G.; Martínez, Alejandra; Pineda, Ángela; Spencer, M. Loreto; Jiménez, M D; Rudolph, M I

doi:10.1111/j.1600-0714.2004.00242.x

Cited by 38 publications

(44 citation statements)

References 44 publications

(69 reference statements)

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“…Histologically, the superficial lamina propia presents extensive basophilic degeneration of collagen (Cavalcante et al, 2008;dos Santos et al, 2003;Markopoulos et al, 2004;Martinez et al, 2005;Rojas et al, 2004). Among other findings, the epithelial lining may display varying degrees of dysplasia ranging from a mild change to carcinoma in situ, and even invasive carcinoma (Araújo et al, 2010;Cavalcante et al;da Silva et al, 2007;Markopoulos et al;Xavier et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia

et al. 2012

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SUMMARY:The extracellular matrix (ECM) plays an important role in the regulation of biological events such as the development of cell migration, proliferation and differentiation. Chronic sun exposure causes changes present in the ECM of actinic cheilitis (AC), a premalignant lesion of the lower lip which helps to understand the carcinogenesis of the lip. This study aimed to investigate elastin, the main component of solar elastosis alternating current in an attempt to establish the relationship between this protein and ECM in epithelial dysplasia. Paraffin embedded tissue sections of the lesions of 35 cases of AC were analyzed by immunohistochemistry for elastin, and became the association with the degree of epithelial dysplasia and age. Highest scores of elastin (+3) was predominant in 45.7% of cases of AC, especially in cases of severe dysplasia (n = 3). When comparing the scores of elastin between the different grades of epithelial dysplasia showed no significant difference (P> 0.05, Kruskal-Wallis). This study was not able to demonstrate the influence of elastin on the severity of epithelial dysplasia in AC. Additional studies on other ECM proteins must be conducted in an attempt to better understand the mechanism of malignant progression of the AC.

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Section: Introductionmentioning

confidence: 99%

Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia

et al. 2012

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“…Several authors emphasize the relationship between chronic inflammation and squamous carcinogenesis [8,19] and consider the hypothesis that the mediators of the inflammatory process play an important role in the process of malignant transformation and progression of actinic cheilitis [20]. Thus, we believe that clinical follow-up of AC lesions is important for the control of acute inflammation caused by sun exposure, in order to eliminate or reduce the effect of these mediators of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Actinic cheilitis: a case report and a review of the literature

Dutra

Nascimento

Soares

2016

Rev. Odonto Ciênc. (Online)

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Objective: This article presents a case report of actinic cheilitis with an acute inflammatory process and need for anti-inflammatory treatment. Case Report: Triamcinolone acetonide in Orabase was prescribed 3 times a day for 15 days, and the patient was advised to use sunscreen and hats. After 7 days, there was a significant improvement in the acute phase and the patient was kept under observation. Conclusion: It is emphasized that it is important to intervene in the evolution of the inflammatory process in premalignant lesions in order to prevent its long-term maintenance.Key words: Cheilitis; Carcinoma; Inflammation Queilite actínica: relato de caso e revisão da literatura RESUMO Objetivo: O presente artigo apresenta um relato de queilite actínica com processo inflamatório agudo e necessidade de tratamento com anti-inflamatório. Relato do Caso: Foi prescrito acetonido de triancinolona em orabase, 3 vezes ao dia, durante 15 dias e orientou-se para uso de protetor solar e chapéu. Após 7 dias, houve melhora significativa do quadro agudo, permanecendo o paciente em proservação. Conclusão: Ressalta-se que em lesões potencialmente malignas, torna-se importante interferir na evolução de processos inflamatórios, impedindo sua permanência por longo período de tempo.

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“…Alguns estudos apontam a elastose solar como um achado histopatológico constante e o mais consistente da QA 1,6,9,11,25,30 . A elastose solar reflete os danos solares ao tecido, podendo ser um importante fator no desenvolvimento da QA, sem, entretanto, ser preditivo para evolução da QA para CCE 15 .…”

Section: Discussionunclassified

“…Histologicamente, a QA pode apresentar alterações epiteliais que incluem atrofi a e diminuição da produção de queratina, sendo comum a ocorrência de displasia 3,[11][12][13] . No tecido conjuntivo, é encontrado infi ltrado infl amatório, além de elastose solar, que é caracterizada pela degeneração das fi bras colágenas, as quais passam a exibir basofi lia e aspecto amorfo 3,9,13 .…”

Section: Introductionunclassified

Queilite actínica: avaliação histopatológica de 44 casos

Arnaud

Soares

Paiva

et al. 2014

Rev. odontol. UNESP

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ResumoObjetivo: Descrever os aspectos epidemiológicos, clínicos e histopatológicos da queilite actínica. Material e método: Foi realizado um estudo retrospectivo a partir de casos com diagnóstico clínico de queilite actínica, registrados no arquivo histopatológico do Serviço de Cirurgia de Cabeça e Pescoço do Hospital Napoleão Laureano, Paraíba, relativos ao período de 2000 a 2007. Foram selecionados 44 blocos parafinados, que apresentavam condições de reavaliação histológica através da confecção de novas lâminas. Os novos cortes foram corados em Hematoxilina e Eosina, e a avaliação histopatológica foi realizada por dois examinadores independentes, sendo as alterações classificadas de acordo com OMS. Realizou-se análise estatística descritiva em programa SPSS for Windows versão 13. Resultado: Do total da amostra, 52,3% (23) dos casos foram diagnosticados em homens e 47,7% (21) em mulheres, com idade variando de 27 a 92 anos. A maioria dos indivíduos (81,9%) tinha mais de 40 anos. Em relação às características histológicas, 68,2% (30) dos casos exibiram algum grau de displasia epitelial, sendo 36,3% (16) classificados como displasia leve, 20,4% (9) como displasia moderada e 11,3% (5), displasia severa. Em 15,9% (7), ocorreu carcinoma de células escamosas. No tecido epitelial de revestimento labial, os achados histológicos mais frequentes e identificados foram presença de degeneração hidrópica (79,5%) e hipergranulose (56,8%). Infiltrado inflamatório foi observado em 88,6% dos casos e elastose solar, em 86,4%. Conclusão: Com base nos resultados da amostra estudada, podemos concluir que a maioria das lesões de queilite actínica acometeu lábio inferior de homens, com mais de 40 anos de idade. A análise histopatológica revelou displasia e atipia celular, infiltrado inflamatório e presença de elastose solar, que são características comuns em lesões de QA.Descritores: Queilite; carcinoma de células escamosas; radiação solar; carcinogênese. AbstractObjective:To describe the epidemiological, clinical and histopathological aspects in actinic cheilitis. Material and method: We conducted a retrospective study from cases with clinical diagnosis of actinic cheilitis recorded in the histopathology of the Service of Head and Neck Napoleon Laureano Hospital, Paraíba, from 2000 to 2007. We selected 44 paraffin blocks to product new slides. These new sections were stained with hematoxylin and eosin, and histopathological evaluation was performed by two independent examiners, and the changes classified according to OMS. We conducted a descriptive statistical analysis in SPSS for Windows version 13. Result: Of the total sample, 52.3% (23) cases were diagnosed in men and 47.7% (21) in women aged from 27 to 92 years old. Most individuals (81.9%) were over 40 years old. Regarding the histologic features, 68.2% (30) of cases showed some degree of epithelial dysplasia, 36.3% (16) classified as mild dysplasia, 20.4% (9) moderate dysplasia and 11.3% (5) severe dysplasia. In 15.9% (7) cases, squamous cell carcinoma of lip was observed. In e...

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Increased mast cell density and protease content in actinic cheilitis

Abstract: The results suggest that increased MC density and protease content may contribute to elastosis formation in AC. In addition, changes in MC(T) distribution may favor AC malignization.

Cited by 38 publications

References 44 publications

Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia

Elastin Accumulation in Actinic Cheilitis with Different Degrees of Epithelial Dysplasia

Actinic cheilitis: a case report and a review of the literature

Queilite actínica: avaliação histopatológica de 44 casos

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