volume 5, issue 9, P662-681 2013
DOI: 10.18632/aging.100595
View full text
|
|
Share
Jae H. Hur, Sepehr Bahadorani, Jacqueline Graniel, Christopher L. Koehler, Matthew Ulgherait, Michael Rera, D. Leanne Jones, David W. Walker

Abstract: A functional decline in tissue stem cells and mitochondrial dysfunction have each been linked to aging and multiple aging-associated pathologies. However, the interplay between energy homeostasis, stem cells, and organismal aging remains poorly understood. Here, we report that expression of the single-subunit yeast alternative NADH dehydrogenase, ndi1, in Drosophila intestinal stem and progenitor cells delays the onset of multiple markers of intestinal aging and extends lifespan. In addition, expression of ndi…

expand abstract