Jae H. Hur, Sepehr Bahadorani, Jacqueline Graniel, Christopher L. Koehler, Matthew Ulgherait, Michael Rera, D. Leanne Jones, David W. Walker
Abstract:A functional decline in tissue stem cells and mitochondrial dysfunction have each been linked to aging and multiple aging-associated pathologies. However, the interplay between energy homeostasis, stem cells, and organismal aging remains poorly understood. Here, we report that expression of the single-subunit yeast alternative NADH dehydrogenase, ndi1, in Drosophila intestinal stem and progenitor cells delays the onset of multiple markers of intestinal aging and extends lifespan. In addition, expression of ndi…
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