Increased locomotor response to novelty and propensity to intravenous amphetamine self-administration in adult offspring of stressed mothers

Deminière, Jean-Marie; Piazza, Pier Vincenzo; Guegan, Gilles; Abrous, Djoher Nora; Maccari, Stefania; Moal, Michel Le; Simon, H.

doi:10.1016/0006-8993(92)91383-p

Cited by 238 publications

(131 citation statements)

References 34 publications

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“…The larger question of the role of prenatal stress, including malnutrition, in the sensitivity to drugs of abuse in adulthood is a topic of active investigation. Maternal stress has been shown to increase amphetamine selfadministration in adult offspring (Deminiere et al, 1992), but to our knowledge no studies have been published that directly examine the effect of prenatal stress on the subsequent development of conditioned place-preference to any drugs of abuse in affected offspring.…”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to cocaine alters the development of conditioned place-preference to cocaine in adult mice

Malanga

Pejchal

Kosofsky

2007

Pharmacology Biochemistry and Behavior

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As addiction is increasingly formulated as a developmental disorder, identifying how early developmental exposures influence later responses to drugs of abuse is important to our understanding of substance abuse neurobiology. We have previously identified behavioral changes in adult mice following gestational exposure to cocaine that differ when assessed with methods employing contingent and non-contingent drug administration. We sought to clarify this distinction using a Pavlovian behavioral measure, conditioned place-preference. Adult mice exposed to cocaine in utero (40 or 20 mg/kg/day), vehicle and pair-fed controls were place-conditioned to either cocaine (5 mg/kg or 20 mg/kg, i.p.) or saline injections. The development of conditioned place-preference to cocaine was impaired in mice exposed to cocaine in utero, and was abolished by fetal malnutrition. A context-specific place-aversion to vehicle but not cocaine injection was observed in prenatally cocaine-exposed mice. Locomotor behavior did not differ among prenatal treatment groups. We conclude that early developmental exposure to cocaine may diminish the subsequent rewarding effects of cocaine in adulthood measured with classical conditioning techniques, and that this is not due to changes in locomotor behavior. Sensitivity to acute stress is also altered by prenatal cocaine exposure, consistent with earlier findings in this model.

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Section: Discussionmentioning

confidence: 99%

Prenatal exposure to cocaine alters the development of conditioned place-preference to cocaine in adult mice

Malanga

Pejchal

Kosofsky

2007

Pharmacology Biochemistry and Behavior

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“…127,159 Rat PS offspring show enhanced response to stress 126,127,135,155,160 and higher behavioral emotionality in several stressful situations. 155,159,[161][162][163][164] Adult PS offspring show many characteristics similar to those seen in depressed humans 165 including HPA dysregulations and anhedonic behaviors. 166,167 Abnormalities in brain neurotransmitter systems have also been reported, most importantly low central 5-HT activity in adult offspring after high maternal and fetal 5-HT.…”

Section: Stressmentioning

confidence: 93%

Serotonergic vulnerability and depression: assumptions, experimental evidence and implications

et al. 2006

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In recent years, the term serotonergic vulnerability (SV) has been used in scientific literature, but so far it has not been explicitly defined. This review article attempts to elucidate the SV concept. SV can be defined as increased sensitivity to natural or experimental alterations of the serotonergic (5-HTergic) system. Several factors that may disrupt the 5-HTergic system and hence contribute to SV are discussed, including genetic factors, female gender, personality characteristics, several types of stress and drug use. It is explained that SV can be demonstrated by means of manipulations of the 5-HTergic system, such as 5-HT challenges or acute tryptophan depletion (ATD). Results of 5-HT challenge studies and ATD studies are discussed in terms of their implications for the concept of SV. A model is proposed in which a combination of various factors that may compromise 5-HT functioning in one person can result in depression or other 5-HT-related pathology. By manipulating 5-HT levels, in particular with ATD, vulnerable subjects may be identified before pathology initiates, providing the opportunity to take preventive action. Although it is not likely that this model applies to all cases of depression, or is able to identify all vulnerable subjects, the strength of the model is that it may enable identification of vulnerable subjects before the 5-HT related pathology occurs. Molecular Psychiatry ( Keywords: serotonin; mood disorders; stress; genetics; sex; tryptophan Involvement of serotonin in depressionMood disorders are one of the most prevalent forms of mental illness. 1 According to the DSM-IV, the lifetime risk for major depressive disorder is between 10 and 25% for women and between 5 and 12% for men. 2 Depression has been studied intensively during the last few decades, but the psychological and neurobiological determinants of depression have not yet been precisely defined. Although several factors are known to contribute to the etiology of depression, it is not clear how these factors cause depression, and why some subjects become depressed while others remain unaffected. In terms of biological factors in the etiology of depression, there are several hypotheses. These include neurotransmitter dysfunctions (serotonin, 5-HT; dopamine, DA; norepinephrine, NE); dysregulations in hypothalamic-pituitary-adrenal (HPA) axis activity; and immune system imbalance. The aim of this article is not to discuss all of these hypotheses in detail, but to evaluate the role that serotonin may play within these hypothesized mechanisms.It is widely accepted that diminished serotonergic (5-HTergic) function is involved in the onset and course of depression. 3,4 The 5-HTergic system is a large and complex system. Although nearly all cell bodies of 5-HTergic neurons are located in the raphe nuclei in the brain stem, the axons of these neurons innervate almost the entire brain. The actions of 5-HT are mediated by 16 types and subtypes of receptors. 5 As the 5-HTergic system is assumed to be a modulatory system, the exact func...

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“…Stress is highly implicated in the etiology of addiction and stressors are considered major precipitating factors in relapse to drug-seeking and -taking [c.f., 152,153,222,[287][288][289][290][291][292][293][294][295]. Like repeated drug administration (see above), repeated exposure to stressors induces morphological abnormalities within glutamatergic pyramidal neurons within the cortex of laboratory animals [e.g., 184,221,[296][297][298].…”

Section: Stressor-induced Regulation Of Homers: Implications For Addimentioning

confidence: 99%

“…It remains to be determined whether or not the prenatal stress-induced alterations in IEG and CC-Homer expression persist into adulthood. However, prenatally stressed animals exhibit profound cognitive, social and sensorimotor deficits [304,305] and increased sensitivity to the psychomotor-activating, motivational and glutamate-sensitizing effects of stimulant drugs as adults [294,295,306]. Interestingly, the behavioral and glutamate phenotype induced by prenatal stress bears striking resemblance to that produced by Homer1 deletion [34,172,173,307].…”

Section: Stressor-induced Regulation Of Homers: Implications For Addimentioning

confidence: 99%

Homers regulate drug-induced neuroplasticity: Implications for addiction

Szumlinski

Ary

Lominac

2008

Biochemical Pharmacology

118

160

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Drug addiction is a chronic, relapsing disorder, characterized by an uncontrollable motivation to seek and use drugs. Converging clinical and preclinical observations implicate pathologies within the corticolimbic glutamate system in the genetic predisposition to, and the development of, an addicted phenotype. Such observations pose cellular factors regulating glutamate transmission as likely molecular candidates in the etiology of addiction. Members of the Homer family of proteins regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. This review summarizes the existing data implicating the Homer family of protein in acute behavioral and neurochemical sensitivity to drugs of abuse, the development of drug-induced neuroplasticity, as well as other behavioral and cognitive pathologies associated with an addicted state.

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Increased locomotor response to novelty and propensity to intravenous amphetamine self-administration in adult offspring of stressed mothers

Cited by 238 publications

References 34 publications

Prenatal exposure to cocaine alters the development of conditioned place-preference to cocaine in adult mice

Prenatal exposure to cocaine alters the development of conditioned place-preference to cocaine in adult mice

Serotonergic vulnerability and depression: assumptions, experimental evidence and implications

Homers regulate drug-induced neuroplasticity: Implications for addiction

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