Increased lipopolysaccharide‐induced hypothermia in neurogenic hypertension is caused by reduced hypothalamic PGE₂ production and increased heat loss

Abstract

The mechanisms involved in hypothermia and fever during systemic inflammation (SI) remain largely unknown. r Our data support the contention that brain-mediated mechanisms are different in hypertension during SI. r Considering that, clinically, it is not easy to assess all mechanisms involved in cardiovascular and thermoregulatory control during SI, the present study sheds light on these integrated mechanisms that may be triggered simultaneously in septic hypertensive patients. r The result obtained demonstrate that, in lipopolysaccharide-induced SI, an increased hypothermia is observed in neurogenic hypertension, which is caused by reduced hypothalamic prostaglandin E 2 production and increased heat loss in conscious rats. r Therefore, the results of the present study provide useful insight for clinical trials evaluating the thermoregulatory outcomes of septic patients with hypertension.

Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates memory impairment during systemic inflammation

“…and gas mixture of H 2 (2%), O 2 (21%), and N 2 (77%) through the same chamber supplied through a gas flowmeter (Cole-Parmer Instrument Company, IL, USA); 3) LPS + Air (n = 23) group that received i.v. -Escherichia coli LPS [(LPS, 1.5 mg/kg −1 , 0111: B4 dissolved in pyrogenic-free saline- Sigma Aldrich ( Amorim et al, 2020 )] and 4) LPS + H 2 group (n = 22).…”