Increased lipid peroxidation by graphene quantum dots induces ferroptosis in macrophages

Shao, Yan; Wang, Liting; Chen, Jiajia; Hunag, Youying; Huang, Yiwei; Wang, Xiaoyang; Zhou, Daxue; Wu, Wen Jeng; Zhang, Qianyu; Li, Fēi; Xia, Xuefeng; Huang, Yi

doi:10.1016/j.impact.2021.100334

Cited by 9 publications

(2 citation statements)

References 37 publications

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“…58 Because PS is nonbiodegradable, 59 PS-NPs induced ferroptosis was caused by the nanomaterial itself rather than by dissolved components or released ions, similar to carbon-based nanoparticles. 60 Our mouse inhalation exposure models further verified that ferritinophagy and ferroptosis were involved in PS-NPs-induced lung injury by inhibiting ferroptosis with Fer-1. In addition, in vivo and in vitro models also confirmed that NCOA4-mediated ferritinophagy-induced ferroptosis in lung epithelial cells was an important mechanism of lung disease pathogenesis.…”

Section: Discussionsupporting

confidence: 63%

“…Several kinds of metal nanoparticles, such as ZnO nanoparticles, are soluble and their induction of ferroptosis is mainly the contribution of Zn ions, which determines the different mechanism of PS-NPs-induced ferroptosis . Because PS is nonbiodegradable, PS-NPs induced ferroptosis was caused by the nanomaterial itself rather than by dissolved components or released ions, similar to carbon-based nanoparticles …”

Section: Discussionmentioning

confidence: 99%

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Ferritinophagy Mediated by Oxidative Stress-Driven Mitochondrial Damage Is Involved in the Polystyrene Nanoparticles-Induced Ferroptosis of Lung Injury

Yang,

Zhang,

et al. 2023

ACS Nano

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Ferritinophagy Mediated by Oxidative Stress-Driven Mitochondrial Damage Is Involved in the Polystyrene Nanoparticles-Induced Ferroptosis of Lung Injury

Yang,

Zhang,

et al. 2023

ACS Nano

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Assessment of the Biological Impact of Engineered Nanomaterials Using Mass Spectrometry‐Based MultiOmics Approaches

Day¹,

Zhang²,

Gaffrey³

et al. 2023

Impact of Engineered Nanomaterials in Genomics and Epigenomics

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Lipidomics Investigation Reveals the Reversibility of Hepatic Injury by Silica Nanoparticles in Rats After a 6‐Week Recovery Duration

Zhao,

Zhu,

Yao

et al. 2024

Small Methods

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Given the inevitable human exposure owing to its increasing production and utilization, the comprehensive safety evaluation of silica nanoparticles (SiNPs) has sparked concerns. Substantial evidence indicated liver damage by inhaled SiNPs. Notwithstanding, few reports focused on the persistence or reversibility of hepatic injuries, and the intricate molecular mechanisms involved remain limited. Here, rats are intratracheally instilled with SiNPs in two regimens (a 3‐month exposure and a subsequent 6‐week recovery after terminating SiNPs administration) to assess the hepatic effects. Nontargeted lipidomics revealed alterations in lipid metabolites as a contributor to the hepatic response and recovery effects of SiNPs. In line with the functional analysis of differential lipid metabolites, SiNPs activated oxidative stress, and induced lipid peroxidation and lipid deposition in the liver, as evidenced by the elevated hepatic levels of ROS, MDA, TC, and TG. Of note, these indicators showed great improvements after a 6‐week recovery, even returning to the control levels. According to the correlation, ROC curve, and SEM analysis, 11 lipids identified as potential regulatory molecules for ameliorating liver injury by SiNPs. Collectively, the work first revealed the reversibility of SiNP‐elicited hepatotoxicity from the perspective of lipidomics and offered valuable laboratory evidence and therapeutic strategy to facilitate nanosafety.

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Increased lipid peroxidation by graphene quantum dots induces ferroptosis in macrophages

Cited by 9 publications

References 37 publications

Ferritinophagy Mediated by Oxidative Stress-Driven Mitochondrial Damage Is Involved in the Polystyrene Nanoparticles-Induced Ferroptosis of Lung Injury

Ferritinophagy Mediated by Oxidative Stress-Driven Mitochondrial Damage Is Involved in the Polystyrene Nanoparticles-Induced Ferroptosis of Lung Injury

Assessment of the Biological Impact of Engineered Nanomaterials Using Mass Spectrometry‐Based MultiOmics Approaches

Lipidomics Investigation Reveals the Reversibility of Hepatic Injury by Silica Nanoparticles in Rats After a 6‐Week Recovery Duration

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