Increased levels of VCAM-1 is associated with higher occurrence of coronary artery disease in adults with moderate to severe obstructive sleep apnea

Lv, Qun; Sun, Haili; Du, Zhiyong; Jiao, Xiaolu; Yu, Huahui; Sun, Qiuju; Fan, Li; Wang, Yu; Li, Linyi; Hu, Chaowei; Qin, Yanwen

doi:10.1016/j.sleep.2021.07.002

Cited by 4 publications

(3 citation statements)

References 45 publications

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“…Vascular cell adhesion factor 1 (VCAM-1) levels were significantly elevated in patients with moderate and severe OSA, and elevated VCAM-1 was positively associated with the severity of CAD in moderate to severe OSA patients. 21 OSA also increases other independent risk factors of CAD such as insulin resistance and obesity. 22 In addition to inducing CAD, OSA can also induce cardiovascular events on patients with existing CAD.…”

Section: Sleep Apnea and Cadmentioning

confidence: 99%

Sleep Disorders and Coronary Artery Disease

Dey¹,

Sun²,

Frishman³

et al. 2022

Cardiology in Review

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A sufficient amount and quality sleep is vital components for maintaining optimal physical wellbeing, cognition, and cardiovascular health. Normal sleep provides us with a low physiological stress that promotes overall cardiovascular health. Sleep disorders are common, and often goes undiagnosed. Patients with sleep disorders, commonly suffer from poor quality of life due to the poor quality of their sleep. They are associated with adverse effects on cardiovascular health, such as coronary artery disease. Sleep disorders discussed in this review article include sleep-disordered breathing (obstructive sleep apnea and central sleep apnea), insomnia and restless leg syndrome. Sleep disorders primarily have four acute adverse cardiovascular consequences. First, intermittent hypoxemia-reoxygenation in arterial blood along with PCO 2 fluctuation; second is excessive arousals; third, decreased parasympathetic and increased sympathetic tone; fourth being the large pressure swings in the intrathoracic cavity. This review focuses on classifications, and prevalence of the three major classes of sleep disorders, and the evidence to date on the association between these sleep disorders and coronary artery disease.

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Section: Sleep Apnea and Cadmentioning

confidence: 99%

Sleep Disorders and Coronary Artery Disease

Dey¹,

Sun²,

Frishman³

et al. 2022

Cardiology in Review

View full text Add to dashboard Cite

show abstract

“…Several studies have investigated the relationship between OSA and biomarkers of inflammation (Imani et al, 2021;Sahlman et al, 2010), cardiovascular disease (Neumann et al, 2019), metabolism (Denver et al, 2011;Punjabi et al, 2002), oxidative stress (Katsoulis et al, 2011;Lavie, 2009), and adhesion molecules (Lv et al, 2021;Pak et al, 2015). While miRNAs, a group of markers that are easily accessible from peripheral blood sampling, relatively small in size (21-23 nucleotides), and exhibit good stability (Zapater et al, 2022), have shown promise in OSA research, research on their association with the disease is still in its early stages.…”

Section: Introductionmentioning

confidence: 99%

The impact of obesity, age, and gender on plasmatic levels of selected glycoprotein biomarkers and miRNA-499 in OSA patients

Kostlivý,

Pešta,

Windrichová

et al. 2024

JAB

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“…Several studies have reported multiple risk factors for OSA, including obesity, sex, fluid retention, adenotonsillar hypertrophy, and smoking [ 5 – 9 ]. However, the pathogenesis of OSA is not fully understood, and current methods of diagnosis and treatment are inadequate.…”

Section: Introductionmentioning

confidence: 99%

Circulating ADAMTS13 Levels Are Associated with an Increased Occurrence of Obstructive Sleep Apnea

Huang

Liu

et al. 2022

Disease Markers

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Background and Aims. Obstructive sleep apnea (OSA) is strongly associated with obesity, metabolic diseases, coronary artery disease (CAD), stroke, hypertension, and other disorders. This study assessed the relationship between circulating a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 (ADAMTS13) levels and the presence of OSA. Materials and Methods. This cross-sectional study included a total of 223 patients. We used a powerful high-throughput multiplexed immunobead-based assay to detect circulating levels of ADAMTS13. The associations between circulating ADAMTS13 levels and OSA were evaluated by multivariate logistic regression analysis. Results. Circulating ADAMTS13 levels were significantly elevated in patients with OSA compared with controls (0.8 vs. 2.7 μg/mL, respectively, P < 0.001 ). After adjusting for confounding factors, circulating ADAMTS13 levels were significantly independently associated with the presence of OSA ( odds ratio = 9.96 , 95% confidence interval (CI) =4.11–24.13, P < 0.001 ). Furthermore, circulating ADAMTS13 levels showed discriminatory accuracy in assessing the presence of OSA (area under the curve: 0.87, 95% CI 0.81–0.93, P < 0.001 ). Conclusion. Circulating ADAMTS13 levels were significantly correlated with the presence of OSA. ADAMTS13 may therefore function as a novel biomarker for monitoring the development and progression of OSA.

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Increased levels of VCAM-1 is associated with higher occurrence of coronary artery disease in adults with moderate to severe obstructive sleep apnea

Cited by 4 publications

References 45 publications

Sleep Disorders and Coronary Artery Disease

Sleep Disorders and Coronary Artery Disease

The impact of obesity, age, and gender on plasmatic levels of selected glycoprotein biomarkers and miRNA-499 in OSA patients

Circulating ADAMTS13 Levels Are Associated with an Increased Occurrence of Obstructive Sleep Apnea

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