Increased levels of triglycerides, BMI and blood pressure and low physical activity increase the risk of diabetes in Swedish women. A prospective 18‐year follow‐up of the BEDA*study

Dotevall, Annika; Johansson, Saga; Wilhelmsen, Lars; Rosengren, Annika

doi:10.1111/j.1464-5491.2004.01189.x

Cited by 99 publications

(74 citation statements)

References 41 publications

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“…This finding concurs with recent studies which reported that blood pressure control is associated with the prevalence of diabetes [5,12,25], especially for women [26]. Also, the prevalence of diabetes for both men and women with serum triglyceride levels of≥ 135 mg/dL appears to have increased more rapidly than for men and women with a triglyceride level of <135 mg/dL.…”

Section: Discussionsupporting

confidence: 74%

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Trend Analysis in the Prevalence of Type 2 Diabetes According to Risk Factors among Korean Adults: Based on the 2001~2009 Korean National Health and Nutrition Examination Survey Data

2014

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Purpose: The objective of this study was to provide a trend analysis of the prevalence of diabetes relative to the socioeconomic, lifestyle, and physiologic risk factors among Korean adults aged over 30 years for a 10-year period using data from the Korean National Health and Nutrition Examination Survey. Methods: Prevalence difference and the slope index of inequality were calculated for each risk factors using binomial regression by considering the repeated cross-sectional features of the data. The prevalence ratio and the relative index of inequality were calculated using log-binomial regression. Linear trend tests were performed using SAS 9.2. Results: Crude prevalence of diabetes increased over the 10-year period, and was higher for men than for women. It was very high for adults 60 years or over, consistently increasing over time. The prevalence among unemployed men, women with higher level of stress, women with hypertension, and adults with serum triglyceride levels over 135 mg/dL increased over the 10-year period in comparison with the respective control group. Conclusion: Considering the rapid economic development and associated lifestyle changes in Korea, action should be taken to control the prevalence of diabetes by both preventing and consistently monitoring these identified risk factors using a public-health approach.

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Section: Discussionsupporting

confidence: 74%

“…The physiologic risk factors of diabetes are reported to be hypertension, serum triglyceride, high density lipoprotein (HDL) cholesterol [12], and body mass index (BMI) [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Trend Analysis in the Prevalence of Type 2 Diabetes According to Risk Factors among Korean Adults: Based on the 2001~2009 Korean National Health and Nutrition Examination Survey Data

2014

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“…[1][2][3] The threat of diabetes, the most well-known consequence of obesity, is particularly alarming, 4 as its chronic course and potentially severe complications have major implications for individual patients and for society. The total annual direct medical costs for the Swedish diabetes type 2 population were estimated to account for about 6% of the total national health care expenditure.…”

Section: Introductionmentioning

confidence: 99%

Orlistat in responding obese type 2 diabetic patients: meta-analysis findings and cost-effectiveness as rationales for reimbursement in Sweden and Switzerland

et al. 2005

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OBJECTIVE:The aim of this study is to review the clinical and economic rationale for the reimbursement of orlistat in responding obese patients with type 2 diabetes. METHODS: Data from seven randomized controlled clinical trials of orlistat in overweight and obese patients with type 2 diabetes were pooled. A subgroup analysis involving patients who achieved a response (defined as a weight loss of Z5% after 12 weeks of treatment) was conducted. The outcomes of the pooled analysis were then used to construct a Markov health economic model covering an 11-y period. The incidences of diabetes-related micro-and macrovascular complications were derived from the United Kingdom Prospective Diabetes Study. The effects of changes in body mass index, and the impact of micro-and macrovascular complications on utilities were derived from published sources. Publicly available cost data were used and are presented here in 2001 Euros. Discounting of 3% was applied. A probabilistic sensitivity analysis was conducted to examine the robustness of results. RESULTS: A total of 1249 patients treated with orlistat and 1230 given placebo were eligible for the intent-to-treat analysis. At the end of the study period, 23% of orlistat patients achieved a weight reduction of Z5%. These patients showed a mean decrease in HbA1C of 1.16%, a weight reduction of 8.6 kg, a reduction in total cholesterol of 5.3% and a reduction in systolic blood pressure of 5.2 mmHg. The base-case economic analysis revealed costs per quality-adjusted life year gained of h14 000 in Sweden and h13 600 in Switzerland. CONCLUSION: The data presented here support the utilization and reimbursement of orlistat in overweight and obese diabetic patients who respond to the treatment.

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“…The result from Pima Indians Community Study also indicated that leisure time physical activity plays a significant role in preventing type 2 diabetes [21]. The Gothenburg BEDA Study found a significant inverse association between leisure time physical activity and the risk of type 2 diabetes among 2017 Swedish women [23].…”

Section: Physical Activity and Type 2 Diabetes In Prospective Epidemimentioning

confidence: 99%

Physical activity in the prevention of type 2 diabetes

Tuomilehto¹,

Hu²,

Lakka³

et al. 2004

Schweiz Ärzteztg

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SummaryType 2 diabetes is a common chronic disease with multiple complications, most notably cardiovascular diseases. In the past decade, the associations of physical activity, physical fitness, and changes in the lifestyle with the risk of type 2 diabetes have been assessed by a number of prospective studies and clinical trials. A few studies also evaluated joint associations of physical activity, Body Mass Index and glucose levels with the risk of type 2 diabetes. The results based on 21 prospective studies and four clinical trials have shown that moderate or high levels of physical activity or physical fitness, and changes in the lifestyle (dietary modification and increase in physical activity) can prevent type 2 diabetes. Not only leisure-time physical activity, but also occupational and commuting physical activities are important components of healthy lifestyle and can protect against type 2 diabetes.

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Increased levels of triglycerides, BMI and blood pressure and low physical activity increase the risk of diabetes in Swedish women. A prospective 18‐year follow‐up of the BEDA*study

Abstract: Among middle-aged Swedish women even very slightly elevated s-TG resulted in a considerably enhanced risk of developing diabetes, which was independent of age, BMI, blood pressure and physical activity.

Cited by 99 publications

References 41 publications

Trend Analysis in the Prevalence of Type 2 Diabetes According to Risk Factors among Korean Adults: Based on the 2001~2009 Korean National Health and Nutrition Examination Survey Data

Trend Analysis in the Prevalence of Type 2 Diabetes According to Risk Factors among Korean Adults: Based on the 2001~2009 Korean National Health and Nutrition Examination Survey Data

Orlistat in responding obese type 2 diabetic patients: meta-analysis findings and cost-effectiveness as rationales for reimbursement in Sweden and Switzerland

Physical activity in the prevention of type 2 diabetes

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