Increased levels of TRH in cerebrospinal fluid from patients with endogenous depression

Kirkegaard, C.; Faber, Jens; Hummer, Lotte; Rogowski, P.

doi:10.1016/0306-4530(79)90006-4

Cited by 131 publications

(25 citation statements)

References 19 publications

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“…Chronic stimulation of the thyrothrophs in the pituitary during depression might be caused by TRH, since TRH levels have been found elevated in CSF in two studies (in total 31 patients) (20,21), although normal levels were found in a third study including 17 patients (22). Serum TSH levels are also influenced by somatostatin, which inhibits the TSH release from the pituitary (23).…”

Section: Tsh In Depressionmentioning

confidence: 99%

The role of thyroid hormones in depression

1998

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Section: Tsh In Depressionmentioning

confidence: 99%

The role of thyroid hormones in depression

1998

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“…However, a blunted response of TSH after TRH stimulation that has been explained by a downregulation of TRH receptors at pituitary level due to a hypersecretion of TRH which is frequently observed in depressed patients [Loosen, 1986;Unden et al, 1987;Hubain et al,1994]. A hypersecretion of TRH in depressed patients is further suggested by increased TRH levels found in their cerebrospinal fluid [Kirkegaard et al, 1979;Banki et al, 1988].…”

Section: Discussionmentioning

confidence: 99%

Effects of Thyrotropin-Releasing Hormone on the Sleep EEG and Nocturnal Hormone Secretion in Male Volunteers

Hemmeter¹,

Rothe²,

Güldner³

et al. 1998

Neuropsychobiology

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Various peptides including corticotropin-releasing hormone (CRH) exert selective effects on sleep structure and noctural secretions of cortisol and growth hormone (GH). In animal studies analeptic effects and sleep disturbances after thyrotropin-releasing hormone (TRH) administration have been observed; studies of endocrine function in depressed patients suggest a pathological activity of CRH and TRH as compared with that in healthy volunteers. As the role of TRH in the regulation of the sleep endocrine pattern in humans has not yet been clarified, we performed a study to examine the effects of pulsatile administration of TRH on the sleep EEG pattern and the nocturnal secretions of cortisol and GH in 7 healthy male subjects. The sleep EEG was recorded from 23.00 to 07.00 h, and blood samples were collected every 20 min from 20.00 to 07.00 h for the analysis of GH and cortisol concentrations during intravenous administration of placebo or 4 × 50 µg TRH at 22.00, 23.00, 24.00, and 01.00 h. In contrast to the well-known effects of CRH on the sleep endocrine pattern, TRH exerts only a weak effect on the sleep EEG which is reflected in a slight decrease in sleep efficiency associated with a trend to wakefulness during the night. Furthermore, after TRH administration, the cortisol rise appeared earlier, and a nonsignificant tendency to an increased secretion of cortisol during the first half of the night was found. The GH secretion did not differ significantly after application of TRH or placebo. The activating, albeit weak, effect of TRH on the sleep EEG and nocturnal cortisol secretion in healthy volunteers confirms and adds to the results previously observed in animals. On the basis of these findings, we surmise that TRH may contribute to the disturbed sleep continuity seen in depressed patients, probably acting as a cofactor of CRH in a synergistic manner.

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“…It was found out that there is a three-fold increase in the TRH levels in depressed individuals in comparison to the controls. Another study demonstrated high levels of TRH in the cerebrospinal fluids of depressed patients [7,8].…”

Section: Trh (Thyroid Releasing Hormone)mentioning

confidence: 99%

Depression, Well-being and Hypothyroidism

Aamir¹

2017

Acta Psychopathol

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Increased levels of TRH in cerebrospinal fluid from patients with endogenous depression

Cited by 131 publications

References 19 publications

The role of thyroid hormones in depression

The role of thyroid hormones in depression

Effects of Thyrotropin-Releasing Hormone on the Sleep EEG and Nocturnal Hormone Secretion in Male Volunteers

Depression, Well-being and Hypothyroidism

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