Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm

Tanabe, Kan; Kawai, Yasuyuki; Kitayama, Michihiko; Akao, Hironobu; Ishida, Ryoko; Motoyama, Atsushi; Wakasa, Minoru; Saito, R.; Aoki, Hirofumi; Fujibayashi, Kousuke; Watanabe, Makoto; Tsuchiya, Taketsugu; Kimura, Hiroko; Yoshida, Kenichi; Kajinami, Kouji

doi:10.1016/j.jjcc.2013.11.017

Cited by 21 publications

(14 citation statements)

References 41 publications

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“…Based on a previous report [17], NT levels were measured by competitive time-resolved fluoroimmunoassay using dissociationenhanced lanthanide fluorescence immunoassay reagents (Perkin-Elmer Life Sciences, Boston, MA, USA). The fluorescence intensity was measured at 340 nm excitation and 610 nm emissions, using an Arvo SX multilabel counter (Perkin-Elmer Life Sciences).…”

Section: Biochemical Nt and Glycer-age Measurementsmentioning

confidence: 99%

Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products

Watanabe

Kawai

Kitayama

et al. 2017

Journal of Cardiology

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Section: Biochemical Nt and Glycer-age Measurementsmentioning

confidence: 99%

Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products

Watanabe

Kawai

Kitayama

et al. 2017

Journal of Cardiology

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“…The precise mechanism by which CAS occurs remains to be elucidated. Nevertheless, several precipitating factors are known, including tobacco use and the administration of provocative agents, such as acetylcholine (Ach), ergonovine, histamine, or serotonin 23. Additionally, endothelial dysfunction related to nitric oxide (NO) deficiency is believed to play an important role in the development of CAS with thickening of coronary artery due to hypertrophied vascular smooth muscle cell (VSMC) by the enhancement activity of angiotensin II and endothelin 2.…”

Section: Introductionmentioning

confidence: 99%

Impact of Diltiazem Alone versus Diltiazem with Nitrate on Five-Year Clinical Outcomes in Patients with Significant Coronary Artery Spasm

Park

Rha

et al. 2017

Yonsei Med J

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PurposeCalcium channel blockers diltiazem and nitrate have been used as selective coronary vasodilators for patients with significant coronary artery spasm (CAS). However, no study has compared the efficacy of diltiazem alone versus diltiazem with nitrate for long-term clinical outcomes in patients with CAS.Materials and MethodsA total of 2741 consecutive patients without significant coronary artery disease with positive CAS by acetylcholine (Ach) provocation test between November 2004 and May 2014 were enrolled. Significant CAS was defined as a narrowing of >70% by incremental intracoronary injection of 20, 50, and 100 µg of Ach into the left coronary artery. Patients were assigned to either the diltiazem group (n=842) or the dual group (diltiazem with nitrate, n=1899) at physician discretion. To adjust for potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. After PSM analysis, two well-balanced groups (811 pairs, n=1622, C-statistic=0.708) were generated.ResultsAt 5 years, there were similar incidences in primary endpoints, including mortality, myocardial infarction, revascularization, and recurrent angina requiring repeat coronary angiography between the two groups. Diltiazem alone was not an independent predictor for major adverse cardiovascular events or recurrent angina requiring repeat coronary angiography.ConclusionDespite the expected improvement of endothelial function and the relief of CAS, the combination of diltiazem and nitrate treatment was not superior to diltiazem alone in reducing mortality and cardiovascular events up to 5 years in patients with significant CAS.

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“…Reactive oxygen species such as superoxide and activated radicals lead to the oxidative modification of the LDL. Clinical studies have shown that MDA-LDL is elevated in patients with atherosclerosis [9,10].…”

Section: Introductionmentioning

confidence: 99%

The association of circulating inflammatory and oxidative stress biomarker levels with diagonal earlobe crease in patients with atherosclerotic diseases

Koyama

Watanabe

Itoh

2016

Journal of Cardiology

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Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm

Abstract: Serum NT significantly increased after coronary vasospasm induced by acetylcholine provocation, suggesting that serum NT could be a biomarker of transient myocardial ischemia and could contribute to the development of VSAP.

Cited by 21 publications

References 41 publications

Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products

Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products

Impact of Diltiazem Alone versus Diltiazem with Nitrate on Five-Year Clinical Outcomes in Patients with Significant Coronary Artery Spasm

The association of circulating inflammatory and oxidative stress biomarker levels with diagonal earlobe crease in patients with atherosclerotic diseases

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