Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F2α in wastewater associated with tobacco use

Ryu, Yoshinori; Gracia-Lor, Emma; Bade, Richard; Baz-Lomba, José Antonio; Bramness, Jørgen G.; Castiglioni, Sara; Castrignanò, Erika; Causanilles, Ana; Covaci, Adrian; Voogt, P. de; Hernández, Félix; Kasprzyk-Hordern, Barbara; Kinyua, Juliet; McCall, Ann-Kathrin; Ort, Christoph; Plósz, Benedek G.; Ramin, Pedram; Rousis, Nikolaos I.; Reid, Malcolm J.; Thomas, Kevin V.

doi:10.1038/srep39055

Cited by 62 publications

(47 citation statements)

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“…The potential rapid degradation of EtS and EtG, especially EtG (Figures a and b), in the sewer system may limit their applicability as biomarkers for the estimation of alcohol consumption in the population, although both of them are still currently used in urinalysis to detect alcohol consumption in individuals . With a complete loss after only 2 hours in both RM and GS reactors, EtG is not recommended to be used to estimate alcohol consumption in WBE studies, which supports the practice in all WBE studies related to alcohol after the initial assessment of Reid et al (Table ). In general, as found in this and other studies, glucuronide compounds are very quickly transformed in wastewater, and hence are not suitable to be used as biomarkers in WBE.…”

Section: Discussionmentioning

confidence: 66%

“…Therefore, the uncertainty caused by in‐sewer stability of Cot and HCot is considered acceptable for WBE studies because it is equal or less than those from chemical analysis and both biomarkers can be used to estimate consumption of tobacco in the population. This finding supported the selection of many studies to use Cot and HCot as biomarkers for tobacco consumption …”

Section: Discussionmentioning

confidence: 99%

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Potential impact of the sewer system on the applicability of alcohol and tobacco biomarkers in wastewater‐based epidemiology

Banks

Lai

Mueller

et al. 2017

Drug Testing and Analysis

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Understanding the actual consumption of alcohol and tobacco in the population is important for forming public health policy. For this purpose, wastewater-based epidemiology has been applied as a complementary method to estimate the overall alcohol and tobacco consumption in different communities. However, the stability of their consumption biomarkers - ethyl sulfate, ethyl glucuronide, cotinine, and trans-3'-hydroxycotinine - in the sewer system has not yet been assessed. This study aimed to conduct such assessment using sewer reactors mimicking conditions of rising main, gravity sewer, and wastewater alone, over a 12-hour period. The results show that cotinine and trans-3'-hydroxycotinine are relatively stable under all sewer conditions while ethyl sulfate was only stable in wastewater alone and gradually degraded in rising main and gravity sewer conditions. Ethyl glucuronide quickly degraded in all reactors. These findings suggest that cotinine and trans-3'-hydroxycotinine are good biomarkers to estimate tobacco consumption; ethyl sulfate may be used as a biomarker to estimate alcohol consumption, but its in-sewer loss should be accounted for in the calculation of consumption estimates. Ethyl glucuronide, and probably most of glucuronide compounds, are not suitable biomarkers to be used in wastewater-based epidemiology due to their in-sewer instability.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Potential impact of the sewer system on the applicability of alcohol and tobacco biomarkers in wastewater‐based epidemiology

Banks

Lai

Mueller

et al. 2017

Drug Testing and Analysis

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show abstract

“…Initially, work was entirely focused upon illicit drug usage, including heroin, cocaine and methamphetamines (Boleda et al, 2007;Castiglioni et al, 2006;Kasprzyk-Hordern et al, 2008;Zuccato et al, 2008) but have since expanded to include a diverse range of other endogenous biomarkers, varying from ones linked to lifestyle choices such as alcohol consumption (Boogaerts et al, 2016;Reid et al, 2011;Rodríguez-Álvarez et al, 2014a), tobacco (Castiglioni et al, 2015;Lai et al, 2017;Rodríguez-Álvarez et al, 2014b;Ben J. Tscharke et al, 2016) and psychoactive substances (Kinyua et al, 2015;Mardal and Meyer, 2014;Reid et al, 2014). Others have investigated general health through oxidative stress markers (Ryu et al, 2016(Ryu et al, , 2015.…”

Section: Water Fingerprinting Via Wastewater-based Epidemiology -A Nementioning

confidence: 99%

Future perspectives of wastewater-based epidemiology: Monitoring infectious disease spread and resistance to the community level

Sims

Kasprzyk-Hordern

2020

Environment International

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447

348

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Infectious diseases are acknowledged as one of the most critical threats to global public health today. Climate change, unprecedented population growth with accelerated rates of antimicrobial resistance, have resulted in both the emergence of novel pathogenic organisms and the re-emergence of infections that were once controlled. The consequences have led to an increased vulnerability to infectious diseases globally. The ability to rapidly monitor the spread of diseases is key for prevention, intervention and control, however several limitations exist for current surveillance systems and the capacity to cope with the rapid population growth and environmental changes. Wastewater-Based Epidemiology (WBE) is a new epidemiology tool that has potential to act as a complementary approach for current infectious disease surveillance systems and an early warning system for disease outbreaks. WBE postulates that through the analysis of population pooled wastewater, infectious disease and resistance spread, the emergence of new disease outbreak to the community level can be monitored comprehensively and in real-time. This manuscript provides critical overview of current infectious disease surveillance status, as well as it introduces WBE and its recent advancements. It also provides recommendations for further development required for WBE application as an effective tool for infectious disease surveillance.

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“…Cityand country-wide studies have focused on monitoring licit 5,6 and illicit drugs [7][8][9] , including sports doping agents 10,11 , and have used these results to estimate public drug consumption 12 . Targeted applications have ranged from monitoring stress-related molecules 13 , plasticizers 3,14 , and pesticides 2 to metabolites associated with alcohol 15 and tobacco 16 ; general population biomarkers 17 ; and the environmental release of pharmaceuticals 18 . In addition to chemical identification, wastewater metabolomics can also be used to estimate population size 19,20 .…”

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confidence: 99%

Longitudinal wastewater sampling in buildings reveals temporal dynamics of metabolites

Evans

Dai

Isazadeh

et al. 2019

Preprint

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Direct sampling of building wastewater has the potential to enable "precision public health" observations and interventions. Temporal sampling offers additional dynamic information that can be used to increase the informational content of individual metabolic "features", but few studies have focused on high-resolution sampling. Here, we sampled three spatially close buildings, revealing individual metabolomics features, retention time (rt) and mass-to-charge ratio (mz) pairs, that often possess similar stationary statistical properties, as expected from aggregate sampling. However, the temporal profiles of features-providing orthogonal information to physicochemical properties-illustrate that many possess significantly different feature temporal dynamics (fTDs) across buildings, with rapid and unpredictable deviations from the mean. Internal to a building, numerous and seemingly unrelated features, with mz and rt differences up to hundreds of Daltons and seconds, display highly correlated fTDs, suggesting non-obvious feature relationships. Data-driven building classification achieves high sensitivity and specificity, and extracts building-identifying features with unique dynamics. Analysis of fTDs from many short-duration samples allows for tailored community monitoring with applicability in public health studies.Wastewater sampling presents a means to monitor the general health 1 , chemical exposure 2,3 , and size 4 of a population in a rapid and noninvasive manner. Many studies have been performed at wastewater treatment plants (WWTPs), as these sites are relatively easy to sample, and yield aggregate information on large populations, e.g. from an entire city 2 . As an example of the correlations that can be captured by such studies, an increase in antipsychotics, antidepressants and other therapeutic drugs was observed in wastewater between 2010 and 2014 in Athens, Greece during a time of significant economic turmoil in the country 5 . Given the proper sampling and analysis methods, wastewater can provide meaningful, community-specific public health information.Most wastewater epidemiology and metabolomics studies have focused on the aggregate chemical load on large populations, typically using targeted metabolomics to acquire highly

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Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F2α in wastewater associated with tobacco use

Cited by 62 publications

References 50 publications

Potential impact of the sewer system on the applicability of alcohol and tobacco biomarkers in wastewater‐based epidemiology

Potential impact of the sewer system on the applicability of alcohol and tobacco biomarkers in wastewater‐based epidemiology

Future perspectives of wastewater-based epidemiology: Monitoring infectious disease spread and resistance to the community level

Longitudinal wastewater sampling in buildings reveals temporal dynamics of metabolites

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