Increased Levels of Soluble Cytokine Receptors in the Synovial Fluid of Temporomandibular Joint Disorders in Relation to Joint Effusion on Magnetic Resonance Images

Kaneyama, Keiseki; Segami, Natsuki; Yoshimura, Hiroshi; Honjo, Miho; Demura, Noboru

doi:10.1016/j.joms.2009.10.027

Cited by 38 publications

(26 citation statements)

References 19 publications

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“…These results are similar to those reported earlier (12, 17, 18, 24, 26). Nevertheless, some investigations have reported significant associations between JE and TMJ-pain, and JE and TMJ-pain associated characteristics (3, 7, 11, 15, 27–31). A possible explanation for these associations may be due to quantification of JE.…”

Section: Discussionmentioning

confidence: 99%

Is There an Association Between Temporomandibular Joint Effusion and Arthralgia?

Nasir

Crow

Mahmoud

et al. 2017

Journal of Oral and Maxillofacial Surgery

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Purpose Literature on joint effusion (JE) and its association with clinical and radiological variables in patients with temporomandibular disorders (TMD) is inconsistent and is characterized by multiple methodological limitations. The primary aim of this investigation was to evaluate the association between magnetic resonance imaging (MRI) identified JE and TMJ arthralgia. The secondary aim of this investigation was to determine the association between JE and other clinical and MRI identified soft tissue characteristics. Methods A retrospective cohort study was conducted. Clinical and soft-tissue imaging assessments were carried out following the Diagnostic Criteria for Temporomandibular Disorders guidelines. The dependent variable was JE and primary independent variable was arthralgia. The secondary independent variables comprised of TMJ-pain associated characteristics, and magnetic resonance identified variables. When applicable either Pearson Chi-square or T-test was used to determine the statistical associations between JE and clinical characteristics, and between JE and MR identified variables. Furthermore, generalized estimating equations (GEE) model was conducted to determine which of the independent clinical and MR identified variables were associated with JE. Results Data for 158 participants, representing 312 joints was extracted. The mean age of the female sample (59.4 %) was 31 ± 11.1 years and of the male sample (40.6 %) was 29.8 ± 9.7 years. No association was found between JE and arthralgia. However, statistically significant associations were found between JE and lateral disc rotation (p = .001) and between disc position in the coronal and sagittal planes (p = .001). The GEE model suggested that disc displacement with reduction (OR = 2.5) was statistically significant contributing factors for JE in the absence of DJD. Conclusion Results indicate that JE is associated with the position of the disc in sagittal plane. No association was found between JE and arthralgia, or TMJ-pain associated clinical characteristics in patients with TMD.

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Section: Discussionmentioning

confidence: 99%

Is There an Association Between Temporomandibular Joint Effusion and Arthralgia?

Nasir

Crow

Mahmoud

et al. 2017

Journal of Oral and Maxillofacial Surgery

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“…Also, the pain intensity reported could be influenced by the presence and level of expression of certain inflammatory mediators in the synovial fluid. 20 Future studies should determine such information from joint fluid analysis. Degenerative changes that are not evident on radiographs may also play a significant role in joint pain.…”

Section: Cbct Tmj Osteoarthritismentioning

confidence: 99%

Correlating cone beam CT results with temporomandibular joint pain of osteoarthritic origin

Palconet¹,

Ludlow²,

Tyndall³

et al. 2012

Dentomaxillofacial Radiology

109

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“…IL-6 levels are an indicator of unsuccessful outcome of TMJ irrigation by arthrocentesis [64]. In addition, sIL-6R was also detected in synovial fluids from patients with ID or OA [65].…”

Section: Il-6mentioning

confidence: 99%

“…3) [75]. In contrast, sIL-6R was detected in synovial fluids from patients with ID and/or OA of TMJ [65]. In the interacapsular pathologic condition of TMJ, MMP production may be enhanced in FLS through the IL-6/sIL-6R/gp 130 complex, as sIL-6R exists in synovial fluids and IL-6 is produced by FLS in the presence of IL-1␤ and/or TNF-␣.…”

Section: Il-6mentioning

confidence: 99%

Molecular aspects in inflammatory events of temporomandibular joint: Microarray-based identification of mediators

Ogura

Kondoh

2015

Japanese Dental Science Review

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Synovial inflammation (synovitis) frequently accompanies intracapsular pathologic conditions of the temporomandibular joint (TMJ) such as internal derangement (ID) and/or osteoarthritis (OA), and is suggested to be associated with symptom severity. To identify the putative factors associated with synovitis, we investigated interleukin (IL)-1␤-and/or tumor necrosis factor (TNF)-␣-responsive genes of fibroblast-like synoviocytes (FLS) from patients with ID and/or OA of TMJ using microarray analysis. In this review, we first summarize the FLS of TMJ and the signaling pathways of IL-1␤ and TNF-␣. Next, we show the up-regulated genes in FLS after stimulation with IL-1␤ or TNF-␣, and summarize the gene functions based on recent studies. Among the top 10 up-regulated factors, molecules such as IL-6 and cycrooxygense-2 have been well characterized and investigated in the inflammatory responses and tissue destruction associated with joint diseases such as RA and OA, but the roles of some molecules remain unclear. The FLS reaction can lead to the synthesis and release of a wide variety of inflammatory mediators. Some of these mediators are detected in joint tissues and synovial fluids under intracapsular pathologic conditions, and may represent potential targets for therapeutic interventions in ID and/or OA of TMJ.

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Increased Levels of Soluble Cytokine Receptors in the Synovial Fluid of Temporomandibular Joint Disorders in Relation to Joint Effusion on Magnetic Resonance Images

Cited by 38 publications

References 19 publications

Is There an Association Between Temporomandibular Joint Effusion and Arthralgia?

Is There an Association Between Temporomandibular Joint Effusion and Arthralgia?

Correlating cone beam CT results with temporomandibular joint pain of osteoarthritic origin

Molecular aspects in inflammatory events of temporomandibular joint: Microarray-based identification of mediators

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