Increased Levels of Retinol Binding Protein 4 in Patients With Advanced Heart Failure Correct After Hemodynamic Improvement Through Ventricular Assist Device Placement

Chavarria, Nelson; Kato, Tomoko S.; Khan, Raffay; Chokshi, Aalap; Collado, Elias; Akashi, Hirokazu; Takayama, Hiroo; Naka, Yoshifumi; Farr, Maryjane; Mancini, Donna; Schulze, P. Christian

doi:10.1253/circj.cj-12-0350

Cited by 23 publications

(29 citation statements)

References 21 publications

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“…Hemodynamicrelated improvement of renal function after LVAD implantation, in the already mentioned cohort of patients with advanced HF, was followed by normalization of initially increased serum RBP4 levels [8]. The authors have also observed an improvement in glucose tolerance, cytokine signalling, and liver function in this cohort, which may somehow explain the decrease in serum RBP4 levels after LVAD implantation.…”

Section: Discussionsupporting

confidence: 57%

“…Experimental studies suggest a cardiac prohypertrophic effect of RBP4 [12,13], which may lead to HF. In addition, an increased serum RBP4 was shown in patients with HF before implantation of a left ventricular assist device (LVAD) [8], but not in patients with DCM and low levels of inflammatory markers [6]. These data suggest that RBP4 is a potential biomarker of LVD.…”

Section: Discussionmentioning

confidence: 95%

“…A link between obesity-related insulin resistance (IR) and HF has also been described [6], including: alteration in glucose and free fatty acid metabolism in cardiac myocytes, induction of inflammation and oxidative stress, and promotion of overactivity of the renin-angiotensin II system [7]. Moreover, HF is associated with low-grade chronic inflammation, sympathetic nervous system hyperactivity, and elevated circulating catecholamine levels [3,8].…”

Section: Introductionmentioning

confidence: 99%

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Plasma Level of Retinol-Binding Protein 4, N-Terminal proBNP and Renal Function in Older Patients Hospitalized for Heart Failure

et al. 2018

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Background/Aim: Elevated plasma concentration of retinol-binding protein 4 (RBP4) has recently emerged as a potential new risk factor for cardiovascular diseases, including hypertension (HT) and coronary artery disease (CAD). Limited data suggest that RBP4 promotes inflammatory damage to cardiomyocytes and participates in the development of heart failure (HF). This study aimed to analyze the relationship between concentrations of plasma RBP4 and serum N-terminal proBNP (NT-proBNP), a powerful biomarker of left ventricle dysfunction, in the older Polish population. Methods: The study sample consisted of 2,826 (1,487 men) participants of the PolSenior study, aged 65 years and older, including a subgroup hospitalized for HF (n = 282). In all subjects, plasma concentrations of RBP4, interleukin-6 (IL-6), serum level of NT-proBNP, and hs-CRP were measured. Additionally, BMI, estimated glomerular filtration rate (eGFR), and HOMA-IR were calculated. The prevalence of HT, CAD, atrial fibrillation (AF), and medication were considered as potential confounders. Results: Similar RBP4 levels were found in subjects with NT-proBNP < 125 and ≥125 ng/mL, with and without AF, and in the subgroups hospitalized for HF with and without AF. Regression analysis revealed no association between log₁₀(NT-proBNP) and log₁₀(RBP4). Plasma levels of RBP4 were increased by HT occurrence and diuretic therapy, while diminished with regard to female gender, age, eGFR values, AF, and IL-6 levels. Conclusion: Our results show that RBP4 is affected by GFR but cannot be considered as an independent biomarker of heart muscle dysfunction.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Plasma Level of Retinol-Binding Protein 4, N-Terminal proBNP and Renal Function in Older Patients Hospitalized for Heart Failure

et al. 2018

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“…Since 2005, the literature has suggested linkages between serum RBP4 concentrations, obesity, impaired insulin responsiveness (103)(104)(105)(106)(107)132 ), fatty liver development (134)(135)(136)(137)(138)(139)(140), vessel wall disease ( 141,142 ), and heart disease ( 143 ). At the molecular level, the best studied of these effects is the action of excessive RBP4 acting as a cytokine activating a signaling cascade within cells, which can eventually lead to both direct and indirect alterations in insulin signaling.…”

Section: Retinoids In Adipose Tissuementioning

confidence: 99%

Retinol and retinyl esters: biochemistry and physiology

O’Byrne

Blaner

2013

Journal of Lipid Research

299

250

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The different retinoid forms present within the body (see Fig. 1 ) are generated by and large through modifi cations to the terminal polar end group of the molecule. Retinol and retinyl esters are the most abundant retinoid forms present in the body. All-trans -retinol is by defi nition vitamin A. When a fatty acyl group is esterifi ed to the hydroxyl terminus of retinol, a storage form of retinol, the retinyl ester, is formed. The most abundant retinyl esters present in the body are those of palmitic acid, oleic acid, stearic acid, and linoleic acid ( 6, 7 ). Although retinyl acetate can be found in supplements to foods and vitamin formulations, only long-chain acyl groups are esterifi ed to retinol by animals. Retinyl esters have no known biological activity aside from retinol storage and for serving as the substrate for the formation of the visual chromophore 11-cis -retinal, which must be formed from all-trans -retinyl ester through linked hydrolysis and isomerization reactions catalyzed by the enzyme RPE65 ( 3,4,8,9 ). Retinol is a transport form and a precursor form, which is enzymatically activated to retinoic acid via a two-step oxidation process. The primary role of retinal is in the eye where 11-cis -retinal is needed for visual pigment formation. In tissues, retinal serves as an intermediate in the synthesis of retinoic acid from retinol ( 6, 7 ). The literature also suggests a direct role for retinal in adipose tissue, where it was shown to inhibit adipogenesis and suppress peroxisome proliferator-activated receptor-␥ (PPAR ␥ ) and retinoid X receptor (RXR) responses in cell culture models and in mouse models fed high-fat diets ( 10 ).Abstract By defi nition, a vitamin is a substance that must be obtained regularly from the diet. Vitamin A must be acquired from the diet, but unlike most vitamins, it can also be stored within the body in relatively high levels. For humans living in developed nations or animals living in present-day vivariums, stored vitamin A concentrations can become relatively high, reaching levels that can protect against the adverse effects of insuffi cient vitamin A dietary intake for six months, or even much longer. The ability to accumulate vitamin A stores lessens the need for routinely consuming vitamin A in the diet, and this provides a selective advantage to the organism. The molecular processes that underlie this selective advantage include effi cient mechanisms to acquire vitamin A from the diet, effi cient and overlapping mechanisms for the transport of vitamin A in the circulation, a specifi c mechanism allowing for vitamin A storage, and a mechanism for mobilizing vitamin A from these stores in response to tissue needs. These processes are considered in this review. Since the identifi cation of fat-soluble A a century ago ( 1 ), retinoids (vitamin A and its natural and synthetic analogs) have been the most extensively studied of the fatsoluble vitamins. This research has identifi ed essential roles for retinoids in many different aspects of mammalian physiology, includ...

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“…Several mechanisms have been proposed to explain the relationship between RBP-4 and IR. RBP-4 is associated with an increase in hepatic gluconeogenesis by enhancing the expression of phosphenolpyruvate carboxykinase, and attenuates insulin signaling in skeletal muscle via phosphatidylinositol 3-kinase [11]. …”

Section: Introductionmentioning

confidence: 99%

The Effect of Acitretin Treatment on Insulin Resistance, Retinol-Binding Protein-4, Leptin, and Adiponectin in Psoriasis Vulgaris: A Noncontrolled Study

Karadağ

Ertuğrul²,

Kalkan

et al. 2013

Dermatology

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Background/Aim: To investigate the effects of acitretin treatment on insulin resistance (IR) and adipokines, particularly retinol-binding protein (RBP)-4. Methods: Thirty-four patients with chronic plaque psoriasis and a control group of 34 healthy volunteers were recruited in the study. Screening for the parameters was performed before starting and after 3 months of acitretin treatment in the psoriasis group. The control group was only evaluated at the beginning of the study and did not receive placebo. We could not compare our results with a placebo control group because of ethical reasons. Results: Basal adiponectin (p = 0.01), insulin (p < 0.0001) levels and homeostasis model assessment (HOMA) IR (p < 0.0001) were significantly higher in psoriasis patients. After the treatment, insulin (p = 0.014), C peptide (p = 0.011), RBP-4 (p < 0.0001) levels and HOMA-IR (p = 0.008) decreased significantly. Posttreatment leptin (p = 0.036) levels were significantly lower than those of the controls. Posttreatment adiponectin (p = 0.005) and insulin (p = 0.048) levels were higher than those of the controls. Conclusions: This study showed for the first time that RBP-4 levels and IR are decreased significantly with acitretin treatment. This finding is very important in psoriasis patients because psoriasis may cause insulin resistance and diabetes. Further experimental and clinical studies are needed to clarify the effect of acitretin on adipocyte structure and behavior.

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Increased Levels of Retinol Binding Protein 4 in Patients With Advanced Heart Failure Correct After Hemodynamic Improvement Through Ventricular Assist Device Placement

Cited by 23 publications

References 21 publications

Plasma Level of Retinol-Binding Protein 4, N-Terminal proBNP and Renal Function in Older Patients Hospitalized for Heart Failure

Plasma Level of Retinol-Binding Protein 4, N-Terminal proBNP and Renal Function in Older Patients Hospitalized for Heart Failure

Retinol and retinyl esters: biochemistry and physiology

The Effect of Acitretin Treatment on Insulin Resistance, Retinol-Binding Protein-4, Leptin, and Adiponectin in Psoriasis Vulgaris: A Noncontrolled Study

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