Increased levels of plasma IL-1b and BDNF can predict resistant depression patients

Abstract

SUMMARY BACKGROUND: There is no strong evidence on the link between inflammatory profile and pattern of drug treatment response in depressive patients that could result in Coronary Artery Disease occurrence. OBJECTIVE: This study aimed to compare the subclinical atherosclerosis markers, inflammatory profile, and BDNF production in Resistant Depression (RD) or Bipolar Affective Disorder (BAD) patients under conventional treatment. METHODS: The population evaluated was comprised of 34 RD, 43 BAD, and 41 controls. Subclinical atherosclerosis markers were evaluated using ultrasonography, tomography, and exercise stress test. Plasma concentrations of TNFα, IL-1β, IL-6, and BDNF were measured using Luminex100™. The usCRP concentration was measured using turbidimetric immunoassay. IL1B, IL6, and TNFA expression were determined using TaqMan®. For the statistical analysis, the significance level was established at p<0.05. RESULTS: Concerning subclinical atherosclerosis markers, only O2 consumption was reduced in the BAD group (p = 0.001). Although no differences were found in gene expression, BDNF and IL-1β plasma concentration was increased in the RD group (p = 0.002 and p = 0.005, respectively) even with an antidepressant treatment, which suggests that these drugs have no effect in IL-1β secretion and that the inflammasome may play a role in therapy response. CONCLUSION: Taken together, both BDNF and IL-1β plasma concentrations could be used to the early identification of RD patients.

Neurological and psychiatric presentations associated with COVID-19

“…Therefore, inflammatory cytokines, such as IL-6, may mediate the occurrence of neuropsychiatric symptoms in patients infected with SARS-CoV-2. Notably, studies have shown that severe depression, generalized anxiety, post-traumatic stress disorder, and other neuropsychiatric diseases are associated with increased expression levels of inflammatory cytokines, including IL-6, IL-8, IL-10, TNF-α, and their receptors, and higher CRP levels [34,37,38]. Our finding also supports the notion that cytokines play an important role in the pathophysiology of neuropsychiatric symptoms.…”

Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic

“… 31 Increased levels of IL-1β could help to identify patients with treatment-resistant depression. 34 Our results suggest that this cytokine may also be involved in burnout syndrome. However, although CBD has been reported to have anti-inflammatory effects, 17 , 18 , 19 , 20 the drug did not prevent increases in IL-1β levels among participants in the current study.…”

Antidepressant mechanism of classical herbal formula lily bulb and Rehmannia decoction: insights from gene expression profile of medial prefrontal cortex of mice with stress‐induced depression‐like behavior

“…RNA‐sequencing validation by qRT‐PCR showed that the upregulated and downregulated genes were consistent between independent experiments (Figure ). These DEGs were mainly involved in inflammation, neurodevelopment, synaptic plasticity, synaptic transmission, neurotropin binding, neurotrophic binding, signal transduction and cellular communication, which are associated with depressive episodes and therapy . These results suggested that the antidepressant activities of LBRD standard decoction might be achieved by targeting multiple targets in the medial prefrontal cortex.…”