Increased levels of NGF in sera of systemic lupus erythematosus patients

Bracci-Laudiero, Luisa; Aloe, Luigi; Levi‐Montalcini, Rita; Galeazzi, Mauro; Schilter, Daniel; Scully, Jackie Leach; Otten, U.

doi:10.1097/00001756-199305000-00025

Cited by 97 publications

(56 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As shown in Fig. 2, alteration of basal NGF levels was found in the synovium of patients affected by rheumatic arthritis (24), and the skin of patients with systemic sclerodermia (119). Moreover, studies on animal models have shown that in many autoimmune inflammatory diseases there is a close correlation between the inflammatory conditions and a variation in the constitutive level of NGF (25,26,120).…”

Section: Ngf and Autoimmune Diseasesmentioning

confidence: 89%

“…Moreover, the circulating levels of NGF change not only with age, but also during neuroendocrine disregulation, after neurologic insults, and during autoimmune and allergic diseases (21)(22)(23)(24)(25)(26). Tlie elevated levels of NGF are often associated with an increase of proinflammatory cytokines, particularly interleukin-1-beta (IL-1|3) and tumor necrosis factor-alpha (TNF-a) (27)(28)(29)(30).…”

mentioning

confidence: 99%

See 1 more Smart Citation

The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases

Aloe

Bracci-Laudiero

Бонини

et al. 1997

Allergy

Self Cite

203

127

View full text Add to dashboard Cite

Numerous studies published in the last 10–15 years have shown that nerve growth factor (NGF), a polypeptide originally discovered in connection with its neurotrophic activity, also acts on cells of the immune system. NGF has been found in various immune organs including the spleen, lymph nodes, and thymus, and cells such as mast cells, eosinophils, and B and T cells. The circulating levels of NGF increase in inflammatory responses, in various autoimmune diseases, in parasitic infections, and in allergic diseases. Stress‐related events both in animal models and in man also result in an increase of NGF, suggesting that this molecule is involved in neuroendocrine functions. The rapid release of NGF is part of an alerting signal in response to either psychologically stressful or anxiogenic conditions in response to homeostatic alteration. Thus, the inflammation and stress‐induced increase in NGF might alone or in association with other biologic mediators induce the activation of immune cells during immunologic insults. A clearer understanding of the role of NGF in these events may be useful to identify the mechanisms implicated in certain neuroimmune and immune dysfunctions.

show abstract

Section: Ngf and Autoimmune Diseasesmentioning

confidence: 89%

mentioning

confidence: 99%

The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases

Aloe

Bracci-Laudiero

Бонини

et al. 1997

Allergy

Self Cite

203

127

View full text Add to dashboard Cite

show abstract

“…In addition, BDNF and NGF are detectable and over-expressed in the synovial tissues and fluids of patients with rheumatoid arthritis (RA) and spondyloarthritis but not in healthy controls (15)(16)(17). Additional evidence exists for an association between increased levels of NTs and susceptibility to inflammatory diseases such as systemic lupus erythematosus (SLE) (18,19), RA, multiple sclerosis, and juvenile chronic arthritis (20 -22). Even a Disease Activity Index in patients with SLE was significantly correlated with serum levels of NGF (19).…”

Section: Discussionmentioning

confidence: 99%

Linkage and Association Study of Neurotrophins and Their Receptors as Novel Susceptibility Genes for Childhood IgA Nephropathy

2011

View full text Add to dashboard Cite

Neurotrophins (NTs) and their receptors (NTRs) are known to be important for pathogenesis of various inflammatory diseases that occur in not only neuronal but also nonneuronal tissues, including kidney. Here, we investigated association between childhood IgA nephropathy (IgAN) and single nucleotide polymorphisms (SNPs) of genes encoding NTs [nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF)] and NTRs [nerve growth factor receptor (NGFR) and neurotrophic tyrosine kinase receptor 1-3 (NTRK1-3)]. The genotyping data of 197 patients and 289 control subjects revealed significant association between NGF SNP rs11102930 and presence of IgAN. Patient subgroup analysis revealed that that the presence of nephrotic range proteinuria (Ͼ40 mg/m 2 /h) was associated with rs6334 of NTRK1 and rs11030104, rs7103411, rs7103873, and rs6484320 of BDNF. Significant genotype differences were observed in podocyte foot process effacement for rs1187321 and rs1187323 of NTRK2. Furthermore, some SNPs showed significantly different genotype distribution between patients with or without pathologically advanced disease markers, specifically in rs6334 of NTRK1. Our results suggest that SNPs of NTs and NTRs are associated with susceptibility, pathological advancement, podocyte foot process effacement, and development of proteinuria in childhood IgAN. (Pediatr Res 69: 299-305, 2011)

show abstract

“…Nerve growth factor (NGF) reportedly accumulates in inflammatory sites or exudates (7,8) caused by various noxious stimuli, including those of autoimmune origin (9,10). NGF is the prototype of target-derived neurotrophic factors critical for development and maintenance of specific peripheral and central neuronal populations (11,12).…”

mentioning

confidence: 99%