Increased levels of cytokines and cytokine activity modifiers in normal pregnancy

Austgulen, Rigmor; Lien, Egil; Liabakk, Nina‐Beate; Jacobsen, Geir; Arntzen, Knut Jørgen

doi:10.1016/0028-2243(94)90291-7

Cited by 96 publications

(55 citation statements)

References 30 publications

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“…Thus, cord blood levels of these param eters appear to be independent of maternal disease and elevated values are potentially useful in the identification of neonates with early-onset sepsis. Similar results were shown for IL-8 [13] whereas Austgulen et al [23] found a significant correlation between ma ternal and umbilical IL-6 concentrations pos sibly due to different study populations.…”

Section: Discussionsupporting

confidence: 74%

Immunologic Parameters in Cord Blood Indicating Early-Onset Sepsis

et al. 1996

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Different immunologic parameters were measured in cord blood to test their usefulness in the early diagnosis of early-onset sepsis. Cord blood levels of circulating intercellular adhesion molecule-1 (cICAM-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) were significantly elevated in septic compared to nonseptic neonates. No significant difference between either population was seen for cord blood C3a and elastase-α₁-proteinase inhibitor complex (Eα₁PI). Measured concentrations of cICAM-1, IL-6 and IL-8 in fetal and maternal blood did not correlate, indicating that the neonate’s response to sepsis is clearly different from the mother. Our data suggest that cord blood measurements of cICAM-1, IL-6 and IL-8 might be useful in identifying neonates with early-onset sepsis.

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Section: Discussionsupporting

confidence: 74%

Immunologic Parameters in Cord Blood Indicating Early-Onset Sepsis

et al. 1996

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“…In contrast to lymphocytic cytokines, IL-1␤, IL-6, and TNF-␣ were spontaneously released by blood cells from mothers as well as their neonates (data not shown), likely reflecting the monocytic activation normally associated with pregnancy and delivery (3,37). As shown in Fig.…”

Section: Vol 68 2000mentioning

confidence: 89%

MaternalTrypanosoma cruziInfection Upregulates Capacity of Uninfected Neonate Cells To Produce Pro- and Anti-Inflammatory Cytokines

Vekemans¹,

Truyens²,

Torrico

et al. 2000

Infect Immun

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“…Contrary to Wegmann's hypothesis, it is surprising that many of the characteristics of a systemic inflammatory response have been demonstrated in normal pregnant women, 59 including increased leukocytes, 60 monocytic 61 and phagocytic activity 62 and the production of pro-inflammatory cytokines, such as IL-6, IL-12, IL-18 and TNF-alpha. 63,64 A classical marker of inflammatory activity, C-reactive protein, is increased beginning as early as the fourth week of gestation. 65 These phenomena show that pregnancy is a well-controlled systemic inflammatory state.…”

mentioning

confidence: 99%

TH17 cells in human recurrent pregnancy loss and pre-eclampsia

2014

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T helper 17 (TH17) cells have been identified as a new lineage of helper T cells and have been shown to be important in host defense against extracellular infectious agents, autoimmune disease and chronic inflammatory diseases. Recently, TH17 cells have also been shown to participate in successful pregnancy, as well as in the pathogenesis of diseases of pregnancy, such as recurrent spontaneous abortion (RSA) and pre-eclampsia (PE). Here, we review our current knowledge of TH17 cells in human RSA and PE. We also discuss how the local uterine microenvironment affects the differentiation of TH17 cells and the mechanisms that regulate TH17 cells during pregnancy. Research into TH17 cells will not only advance our understanding of TH17-related pregnancy complications, but will also facilitate the design of novel therapies for reproductive diseases.

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Increased levels of cytokines and cytokine activity modifiers in normal pregnancy

Cited by 96 publications

References 30 publications

Immunologic Parameters in Cord Blood Indicating Early-Onset Sepsis

Immunologic Parameters in Cord Blood Indicating Early-Onset Sepsis

MaternalTrypanosoma cruziInfection Upregulates Capacity of Uninfected Neonate Cells To Produce Pro- and Anti-Inflammatory Cytokines

TH17 cells in human recurrent pregnancy loss and pre-eclampsia

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