Increased levels of circulating (TNF-α) is associated with (-308G/A) promoter polymorphism of TNF-α gene in Diabetic Nephropathy

Effects of TNF-α-308G/A Polymorphism on the Risk of Diabetic Nephropathy and Diabetic Retinopathy: An Updated Meta-Analysis

“…Animal models of insulin resistance and obesity have shown that TNF-α inhibits insulin receptor signaling [54,55] by promoting serine phosphorylation of insulin receptor substrate (IRS) proteins, and then inhibiting insulin-stimulated tyrosine phosphorylation and impairing insulin signaling accelerate development of the course of DN and DR. Increasing studies have discussed the relationship of the TNFα-308 G/A polymorphism with the susceptibility to DN and DR, but no consistent conclusion has been achieved yet. For example, Umapathy et al implicated a strong association between cytokine the TNF-α-308 G/A polymorphism in patients with DN in serval Asian population [30], whereas the study by Dabhi et al exhibited no significant association between the TNF-α-308 G/A polymorphism and the risk of DN [12]. Additionally, there are existing inconclusive results in DR, for instance, in Caucasians, Lindholm et al revealed the TNF-α A allele was associated with increased risk for DR in type 2, but not in type 1 diabetic patients.…”

“…1). Ultimately, 14 eligible articles (including 19 independent studies) were selected for the present meta-analysis [12,[21][22][23][24][25][26][27][28][29][30][31][32][33]. Among these, 11 studies exist with outcomes for DN and 8 studies with outcomes for DR to incorporate into this meta-analysis.…”

Association of TGF-β1 and TNF-α genes polymorphisms with the kidney scars forming risk in children with vesicoureteral reflux

“…The single-nucleotide polymorphism of the TNF gene at the -308promoter region is associated with changes in the production and transcription of this cytokine (UMAPATHY et al, 2018). Allele A (TNF2) is associated with higher levels of TNF, therefore inflammatory nephropathy may be more common in patients with allele A due to the increased production of this cytokine.…”

“…Association studies of kidney diseases have shown variable results: Umapathy and associates (UMAPATHY et al, 2018) observed the association of TNF-α polymorphism with diabetic nephropathy, while Dabhi and associates (DABHI et al, 2015) failed to prove this. Kim and associates (KIM et al, 2004) did not find any difference in the distribution of genotype between patients with nephrotic syndrome and the control group.…”

Significance of the tumor necrotic factor alpha in mechanisms of nephropathy development in type 2 diabetes mellitus

“…Отримані результати підтверджували дані про те, що у хворих на ЦД 2 типу-носіїв мінорного генотипу А/А rs1800629 експресія гену TNFα була збільшена більш ніж у 4 рази, що супроводжувалося суттєвим збільшенням рівнів у крові TNFα [20]. У дослідженнях [18,21] [21]. У наших інших дослідженнях [22] показано, що зв'язок із наявністю діабетичної нефропатії, визначеної за швидкістю клубочкової фільтрації, мав поліморфізм rs1799983 гена NOS3 (χ 2 = 10,15; р = 0,06); алель Т був асоційований із ступенем декомпенсації діабету, погіршенням функції нирок та артеріальною гіпертензією (p < 0,05).…”