Increased levels of circulating intercellular adhesion molecule 1 in kawasaki disease

Abstract

Objective. We investigated whether levels of intercellular adhesion molecule 1 (ICAM-1) antigen shed into the circulation increase during acute Kawasaki disease (KD). We also compared ICAM-1 levels in acute KD with those in anaphylactoid purpura (AP) and in measles.Methods. Serum ICAM-1 levels were measured by a double-determinant immunoassay using 2 monoclonal antibodies in the FAST (Falcon assay screening test) system. Serum levels of tumor necrosis factor a (TNFa) were measured by a specific and sensitive sandwich enzyme immunoassay.Results. Patients with KD, but not those with AP or measles, had increased levels of shed ICAM-1 antigen in serum samples obtained during acute stages. Moreover, during the acute stage, KD patients with coronary artery lesions (CAL) had still higher levels of shed ICAM-1 than did those without CAL. We found a

Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model

“…In addition, we demonstrated that IgG-APS increased concentrations of sICAM-1, but pretreatment with fluvastatin suppressed this increase. Previous studies have demonstrated that increases in the circulating concentrations of these molecules are proportional to the increases in their cell membrane expression (59)(60)(61)(62)(63). Furthermore, the soluble phase of this molecule seems to have biologic activity.…”

Circulating soluble intercellular adhesion molecule-1 (sICAM-1) in patients with sarcoidosis

“…Cellular ICAM-1 expression and shedding of ICAM-1 are inducible or augmentable by proinflammatory cytokines (IFN-, TNF-and IL-1 ) [13,14,21]. Elevated concentrations of circulating sICAM-1 have been found in inflammatory diseases such as idiopathic pulmonary fibrosis (IPF) [15], Kawasaki disease [16], rheumatoid arthritis (RA) [17], tuberculosis [18], chronic liver diseases [19] and extrinsic allergic alveolitis [20]. Circulating sICAM-1 concentrations significantly correlate with circulating TNF-concentrations in Kawasaki disease [16], RA [17] and tuberculosis [18], and with circulating IFN-concentrations in tuberculosis [18].…”

“…Shedding of ICAM-1 is increased by treatment with TNF-and IL-1 [14]. Circulating sICAM-1 has been reported to be elevated in patients with inflammatory diseases [15][16][17][18][19][20], and excess release of proinflammatory cytokines seems to be related to the elevation of circulating sICAM-1 in these disorders.…”

Soluble Intercellular Adhesion Molecule-1 Concentrations in Patients with Subacute Thyroiditis and in Patients with Graves' Disease with or without Ophthalmopathy.

“…Similarly, a sustained increase in sICAM-1 was observed even after clinical improvement in other inflammatory diseases [37,38]. Although sICAM-1 levels were still higher after 3 months of steroid therapy, changes in sICAM-1 levels seem to be correlated with the degree of inflammatory activity in GO and the response to steroid therapy, although no direct relation was found between sICAM-1 and the ophthalmopathy-index score.…”