Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naïve schizophrenia patients

Guest, Paul C.; Wang, L; Harris, Laura W.; Burling, Keith; Levin, Yishai; Ernst, Agnes; Wayland, Matthew T.; Umrania, Yagnesh; Herberth, Marlis; Koethe, Dagmar; Beveren, J.M. Van; Rothermundt, Matthias; McAllister, George; Leweke, F. Markus; Steiner, Johann; Bahn, Sabine

doi:10.1038/mp.2009.81

Cited by 121 publications

(79 citation statements)

References 8 publications

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“…Antipsychotics, mood stabilizers, and antidepressants used to treat psychiatric disorders have metabolic side effects, but metabolic disturbances in psychiatric patients also occur independently of drug effects. For instance, dyslipidemia and insulin resistance may precede start of medication in SCZ [17][18][19]. The close 5 relationship between psychiatric disorders and metabolic disturbances has led to the concept of a "metabolic mood syndrome", positing the existence of common biological mechanisms underlying both conditions [20][21][22][23].…”

Section: Metabolic Comorbidity In Psychiatric Disordersmentioning

confidence: 99%

Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders

Barandas

Landgraf

McCarthy

et al. 2015

Curr Psychiatry Rep

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Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder are often accompanied by metabolic dysfunction symptoms, including obesity and diabetes. Since the circadian system controls important brain systems that regulate affective, cognitive, and metabolic functions, and neuropsychiatric and metabolic diseases are often correlated with disturbances of circadian rhythms, we hypothesize that dysregulation of circadian clocks plays a central role in metabolic comorbidity in psychiatric disorders. In this review paper, we highlight the role of circadian clocks in glucocorticoid, dopamine, and orexin/melanin-concentrating hormone systems, and describe how a dysfunction of these clocks may contribute to the simultaneous development of psychiatric and metabolic symptoms.3

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Section: Metabolic Comorbidity In Psychiatric Disordersmentioning

confidence: 99%

Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders

Barandas

Landgraf

McCarthy

et al. 2015

Curr Psychiatry Rep

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“…Although these effects can result from antipsychotic medications, they were also observed decades before the development and clinical use of antipsychotics. In addition, recent evidence has emerged that patients can show these effects at the first clinical presentation and prior to receiving medication 85,86 and blood-based analyses have demonstrated hyperinsulinaemia and abnormalities in secretion of other endocrine factors at first presentation of symptoms 87,88 .…”

Section: Effects On the Insulin Signalling And The Hpa Axis In Schizomentioning

confidence: 99%

“…In the case of psychiatric disorders, such as schizophrenia, therapeutic strategies that target the underlying metabolic dysfunction could provide an effective alternative to traditional antipsychotic medications 87 . This possibility is supported by the finding that the insulin-sensitizing agents metformin and rosiglitazone can correct the insulin resistance that seems to come hand in hand with antipsychotic treatment without inhibiting the antipsychotic drug efficacy in treating the disease 105 .…”

Section: Therapeutic Implicationsmentioning

confidence: 99%

“…In a recent study of 66 first onset schizophrenia patients and 68 matched control subjects, we used a series of immunoassays to measure the levels of insulin, proinsulin and des 31,32 proinsulin using two-site time-resolved fluorescence assays employing different combinations of monoclonal antibodies that discriminate between the specific forms of the molecule 87,89 . Also, C-peptide and the insulin secretory granule protein chromogranin A were measured using commercially-available immunoassays.…”

Section: Effects On the Insulin Signalling And The Hpa Axis In Schizomentioning

confidence: 99%

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Os efeitos do estresse na função do eixo hipotalâmico-pituitário-adrenal em indivíduos com esquizofrenia

Guest

Martins-de-Souza²,

Rahmoune

et al. 2012

Arch. Clin. Psychiatry (São Paulo)

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Over the last few decades, evidence has been emerging that the pathogenesis of psychiatric disorders such as schizophrenia can involve perturbations of the hypothalamic-pituitary-adrenal (HPA) axis. Variations in the manifestation of these effects could be related to the differences in clinical symptoms between affected individuals as well as to differences in treatment response. Such effects can also arise from the complex interaction between genes and environmental factors. Here, we review the effects of maternal stress on abnormalities in HPA axis regulation and the development of psychiatric disorders including schizophrenia. Studies in this area may prove critical for increasing our understanding of the multi-dimensional nature of schizophrenia. Further research in this area could ultimately lead to the development of improved diagnostics and novel therapeutic approaches for treating this debilitating psychiatric condition.Guest FL, et al. / Rev Psiq Clín. 2013;40(1):20-7 Keywords: Psychiatric disorders, schizophrenia, HPA axis dysfunction, diagnosis, biomarkers. ResumoNas últimas décadas, têm surgido evidências sugerindo que a patogênese de desordens psiquiátricas, tais como a esquizofrenia, pode envolver perturbações no eixo hipotalâmico-pituitário-adrenal (HPA). Variações na manifestação desses efeitos poderiam estar relacionadas a diferenças em sintomas clínicos entre os indivíduos afetados, assim como a diferenças na resposta ao tratamento. Tais efeitos podem também ser originados de complexas interações entre genes e fatores ambientais. Aqui, revisamos os efeitos do estresse maternal em anormalidades na regulação do eixo HPA e desenvolvimento de desordens psiquiátricas, incluindo a esquizofrenia. Estudos nessa área podem gerar o aumento do nosso entendimento da natureza multidimensional da esquizofrenia. Posterior pesquisa nesse campo poderia, em última instância, levar ao desenvolvimento de melhores diagnósticos e novas abordagens terapêuticas para essa debilitante condição psiquiátrica.Guest FL, et al. / Rev Psiq Clín. 2013;40(1):20-7 Palavras-chave: Desordens psiquiátricas, esquizofrenia, disfunção do eixo HPA, diagnóstico, biomarcadores.

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“…30,57,58 Insulinrelated peptides, such as proinsulin and peptide C, were also shown to be increased in this population, regardless of glucose levels. 59 Alterations in the plasma levels of lipids are another common metabolic alteration of schizophrenia and BD. Triglyceri des and lipoproteins, such as low-density and high-density lipoproteins (LDL and HDL), have shown abnormal levels in chronic 60,61 and first-episode, drugnaive patients.…”

Section: Metabolic Systems Involved In the Pathophysiology Of Psychiamentioning

confidence: 99%

The "selfish brain" hypothesis for metabolic abnormalities in bipolar disorder and schizophrenia

Mansur

Brietzke

2012

Trends Psychiatry Psychother.

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A hipótese do "cérebro egoísta" para alterações metabólicas no transtorno bipolar e na esquizofreniaThe "selfish brain" hypothesis for metabolic abnormalities in bipolar disorder and schizophrenia AbstractMetabolic abnormalities are frequent in patients with schizophrenia and bipolar disorder (BD), leading to a high prevalence of diabetes and metabolic syndrome in this population. Moreover, mortality rates among patients are higher than in the general population, especially due to cardiovascular diseases. Several neurobiological systems involved in energy metabolism have been shown to be altered in both illnesses; however, the cause of metabolic abnormalities and how they relate to schizophrenia and BD pathophysiology are still largely unknown. The "selfish brain" theory is a recent paradigm postulating that, in order to maintain its own energy supply stable, the brain modulates energy metabolism in the periphery by regulation of both allocation and intake of nutrients. We hypothesize that the metabolic alterations observed in these disorders are a result of an inefficient regulation of the brain energy supply and its compensatory mechanisms. The selfish brain theory can also expand our understanding of stress adaptation and neuroprogression in schizophrenia and BD, and, overall, can have important clinical implications for both illnesses. Keywords: Schizophrenia, bipolar disorder, metabolism, brain metabolism, stress, allostasis. ResumoAlterações metabólicas são frequentes em pacientes com esquizofrenia e transtorno bipolar (TB), levando a uma alta prevalên-cia de diabetes e síndrome metabólica nessa população. Além disso, as taxas de mortalidade entre pacientes são mais altas do que na população geral, especialmente em decorrência de doenças cardiovasculares. Vários sistemas neurobiológicos envolvidos no metabolismo energético têm demonstrado alterações nas duas doenças; no entanto, a causa das alterações metabó-licas e a forma como elas se relacionam com a fisiopatologia da esquizofrenia e do TB ainda são arenas em grande parte desconhecidas. A teoria do "cérebro egoísta" é um paradigma recente que postula que, para manter estável seu próprio fornecimento de energia, o cérebro modula o metabolismo da energia na periferia regulando tanto a alocação quanto a ingestão de nutrientes. Apresentamos neste artigo a hipótese de que as alterações metabólicas observadas nesses transtornos são resultado de uma regulação ineficiente do fornecimento de energia do cérebro e seus mecanismos compensatórios. A teoria do cérebro egoísta também pode expandir nosso entendimento sobre a adaptação ao estresse e a neuroprogressão na esquizofrenia e no TB, e, acima de tudo, pode ter implicações clínicas importantes para as duas doenças. Descritores: Esquizofrenia, transtorno bipolar, metabolismo, metabolismo cerebral, estresse, alostase.

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Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naïve schizophrenia patients

Cited by 121 publications

References 8 publications

Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders

Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric Disorders

Os efeitos do estresse na função do eixo hipotalâmico-pituitário-adrenal em indivíduos com esquizofrenia

The "selfish brain" hypothesis for metabolic abnormalities in bipolar disorder and schizophrenia

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