Increased levels of autoantibodies against copper-oxidized low density lipoprotein, malondialdehyde-modified low density lipoprotein and cardiolipin in patients with rheumatoid arthritis

Cvetkovic, Jasmina Trifunovic

doi:10.1093/rheumatology/41.9.988

Cited by 39 publications

(23 citation statements)

References 45 publications

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“…124 aPLs as well as antibodies against OxLDL are raised in RA, but their clinical importance for CVD and atherosclerosis is not clear in this context and is likely to be complex. 125 Also in RA, lipid peroxidation may play a role, and interestingly, OxLDL-containing foam cells have been detected in synovia from RA patients. 126 Also interesting, HSPs are implicated in RA and atherosclerosis, although immune reactivity to HSPs in RA appears to play a somewhat different role, being protective in many cases.…”

Section: Ra and Other Autoimmune Conditions In Relation To Atherosclementioning

confidence: 99%

Atherosclerosis in Patients With Autoimmune Disorders

Frostegård

2005

ATVB

206

164

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Abstract-Recent findings indicate that presence of activated immune competent cells and inflammation are typical of atherosclerosis, the main cause of cardiovascular disease (CVD). The risk of CVD is very high in a prototypic autoimmune disease, systemic lupus erythematosus (SLE), and is also raised in other autoimmune diseases such as rheumatoid arthritis. Autoimmunity-related CVD and atherosclerosis are important clinical problems. They may also shed light on interactions between immune reactions and atherosclerosis development and manifestations, not least in women, who have a much higher risk of autoimmune disease than men. In general, a combination of traditional and nontraditional risk factors, including dyslipidemia (and to a varying degree, hypertension, diabetes, and smoking), inflammation, antiphospholipid antibodies (aPLs), and lipid oxidation, contribute to CVD in autoimmune diseases. Premature atherosclerosis is likely to be a major underlying mechanism, although distinctive features, if any, of autoimmunity-related atherosclerosis compared with "normal" atherosclerosis are not clear. One interesting possibility is that factors such as inflammation, neoepitopes on endothelial cells, or aPLs make atherosclerotic lesions in autoimmune disease more prone to rupture than in "normal" atherosclerosis. Some cases of autoimmunity-related CVD may be more related to thrombosis than atherosclerosis. Whether premature atherosclerosis is a general feature of autoimmune diseases such as SLE or only affects a subgroup of patients whereas others do not have an increased risk remains to be demonstrated. Treatment of patients with autoimmune disease should also include CVD aspects and be focused on traditional risk factors as well as on disease-related factors. Hopefully novel therapeutic principles will be developed that target the causes of the inflammation present in atherosclerotic lesions.

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Section: Ra and Other Autoimmune Conditions In Relation To Atherosclementioning

confidence: 99%

Atherosclerosis in Patients With Autoimmune Disorders

Frostegård

2005

ATVB

206

164

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“…Thus, it is not surprising that an association was found between the presence of anti-oxLDL antibodies and atherosclerosis and CVD. [25][26][27][28][29][30][31] OxLDL as an Agent in the Development of Atherosclerosis and CVD LDL can be oxidatively modified in vivo to be an immunogen associated with the progression of atherosclerosis and CVD. 32,33 In a study using a mouse model of experimental antiphospholipid syndrome (APS), mice immunized with oxLDL exhibited a significantly more severe form of the disease compared with native LDL-immunized mice, as expressed by lower platelet counts, longer activated partial thromboplastin time, and higher fetal resorption rates.…”

Section: Oxldl: a Notorious Molecule That Maymentioning

confidence: 99%

“…Elevated levels of anti-oxLDL antibodies were found in patients with autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and APS, 16,26,30,[72][73][74][75][76][77][78][79][80][81][82][83][84] as well as in other conditions such as diabetes mellitus, 71 uremia, 77 chronic periaortitis, hepatocellular carcinoma, ␤-thalassemia, psoriasis, and preeclampsia and eclampsia (Table 2).…”

Section: Pathogenic Role Of Anti-oxldl Antibodies In Humansmentioning

confidence: 99%

Are Anti–Oxidized Low-Density Lipoprotein Antibodies Pathogenic or Protective?

et al. 2004

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“…It has been suggested that anti-oxLDL antibodies might possess pathogenic as well as protective effects (5). The pathogenic effects of anti-oxLDL antibodies is supported by observations of elevated IgG seen in lesions (6) in the sera of patients with coronary disease (7,8), peripheral vascular disease (9), and with syndromes associated with accelerated atherosclerosis such as hypertension, diabetes, and immune-mediated diseases (e.g., rheumatoid arthritis, systemic lupus erythematosis) (10,11). However, others have speculated that the See page 2313 higher levels of anti-oxLDL antibodies, in particular IgM autoantibodies, observed in children compared with levels in adults might serve a protective purpose.…”

mentioning

confidence: 98%