Increased levels of air pollution and a decrease in the human and mouse male-to-female ratio in São Paulo, Brazil

Lichtenfels, A.J.F.C.; Gomes, J.B.; Pieri, P.C.; Miraglia, Simone Georges El Khouri; Hallak, Jaime Eduardo Cecílio; Saldiva, Paulo Hilário Nascimento

doi:10.1016/j.fertnstert.2006.06.023

Cited by 65 publications

(51 citation statements)

References 13 publications

(8 reference statements)

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“…Over the past few years an increasing amount of evidence derived from studies focused particularly on male fertility and pregnancy outcome showed the negative effects of environmental contaminants derived from traffic emissions, including ozone (O3), CO, SOx, NOx, benzene, formaldehyde, PAHs, and suspended PM present in urban air on human reproductive health [9][10][11][12][13][14]. In contrast, few studies were able to demonstrate an association between air pollution and fertility impairment in women, probably due to the multiplicity of factors involved in female reproductive function [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

Perin

Maluf

Czeresnia

et al. 2010

J Assist Reprod Genet

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Purpose To assess the potential effects of short-term exposure to particulate air pollution during follicular phase on clinical, laboratory, and pregnancy outcomes of women undergoing IVF/ET. Methods Retrospective cohort study of 400 first IVF/ET cycles of women exposed to ambient particulate matter during follicular phase. Particulate matter (PM) was categorized into quartiles (Q 1 : ≤30.48 µg/m 3 , Q 2 : 30.49-42.00 µg/m 3 , Q 3 : 42.01-56.72 µg/m 3 , and Q 4 : >56.72 µg/m 3 ). Results Clinical, laboratory, or treatment variables were not affected by follicular phase PM exposure periods. Women exposed to Q 4 period during the follicular phase of conception cycles had a higher risk of miscarriage (odds ratio, 5.05; 95% confidence interval: 1.04-25.51) when compared to women exposed to Q 1-3 periods. Conclusion Our results show an association between brief exposure to high levels of ambient PM during the preconceptional period and early pregnancy loss, although no effect of this exposure on clinical, laboratory, and treatment outcomes was observed.

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Section: Introductionmentioning

confidence: 99%

Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

Perin

Maluf

Czeresnia

et al. 2010

J Assist Reprod Genet

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“…There are reasons to assume that this increasing environmental pollution and the broad usage of biocides not only affects human health in general, but also fertility in particular, partly due to endocrine disruption but also due to increased oxidative stress. Several reviews and studies from animal model systems as well as population studies in areas of heavy environmental pollution in South America and China support suggestions that human fertility declines in these regions (Mohallem et al, 2005;; Lichtenfels et al, 2007;; Koifman et al, 2002;; Huang et al, 2010). Regarding male fertility, reproduction does not only require normal sperm parameters in terms of sperm concentration and motility, but also the integrity of the genetic constitution of the spermatozoa.…”

Section: Discussionmentioning

confidence: 95%

Impact of antioxidative supplementation on semen quality according to MSOME criteria

Ajayi¹,

Okhowat²,

Spitzer³

et al. 2013

JBRA Assisted Reproduction

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“…The whole body and heart weights were obtained from each animal. The animals were also used for data collection for toxicological parameters on the respiratory (upper airways) and reproductive system (Camargo Pires- Neto et al 2006;Lichtenfels et al 2007). …”

Section: Animals and Experimental Groupsmentioning

confidence: 99%

Effects of Chronic Exposure to Air Pollution from Sao Paulo City on Coronary of Swiss Mice, from Birth to Adulthood

et al. 2009

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To explore the hypothesis that air pollution promotes cardiovascular changes, Swiss mice were continuously exposed, since birth, in two open-top chambers (filtered and nonfiltered for airborne particles 0.3 mm) placed 20 m from a street with heavy traffic in downtown Sao Paulo, twenty-four hours per day for four months. Fine particle (PM 2.5 ) concentration was determined gravimetrically; hearts were analyzed by morphometry. There was a reduction of the PM 2.5 inside the filtered chamber (filtered ¼ 8.61+0.79 mg/m 3 , nonfiltered ¼ 18.05+1.25 mg/m 3 , p < .001). Coronary arteries showed no evidence of luminal narrowing in the exposed group but presented higher collagen content in the adventitia of LV large-sized and RV midsized vessels (p ¼ .001) and elastic fibers in both tunicae adventitia and intima-media of almost all sized arterioles from both ventricles (p ¼ .03 and p ¼ .001, respectively). We concluded that chronic exposure to urban air since birth induces mild but significant vascular structural alterations in normal individuals, presented as coronary arteriolar fibrosis and elastosis. These results might contribute to altered vascular response and ischemic events in the adulthood.

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Increased levels of air pollution and a decrease in the human and mouse male-to-female ratio in São Paulo, Brazil

Cited by 65 publications

References 13 publications

Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

Impact of antioxidative supplementation on semen quality according to MSOME criteria

Effects of Chronic Exposure to Air Pollution from Sao Paulo City on Coronary of Swiss Mice, from Birth to Adulthood

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