Increased Levels of 25 Hydroxyvitamin D and 1,25-Dihydroxyvitamin D After Rosuvastatin Treatment: A Novel Pleiotropic Effect of Statins?

Yavuz, Bünyamin; Ertuğrul, Derun Taner; Cil, Hicran; Ata, Naim; Akın, Kadir Okhan; Yalçın, Ahmet Arif; Küçükazman, Metin; Dal, Kursad; Hokkaomeroglu, Murat Sevket; Yavuz, Burcu Balam; Tutal, Emre

doi:10.1007/s10557-009-6181-8

Cited by 103 publications

(85 citation statements)

References 19 publications

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“…Previous studies reported different results about the association between statin use and serum 25(OH)D. Rosuvastatin (6,8) and atorvastatin (7) were found to increase serum levels, whereas fluvastatin and simvastatin did not change these levels significantly (6,37). We observed no significant association between statin use and serum 25(OH)D. In the first cohort we performed the same analysis, despite the user group being less than 5% of the population.…”

Section: Discussionmentioning

confidence: 64%

“…To our knowledge, information about the influence of medicines on serum 25(OH)D is limited. For example, some statins (6,7,8) are found to elevate serum 25(OH)D, whereas anti-epileptic drugs lower serum 25(OH)D (9,10). Further knowledge about associations is warranted, because of the large influence of vitamin D in several physiological processes (1) and the possibility to prescribe vitamin D supplements in case of a lowering effect.…”

Section: Introductionmentioning

confidence: 99%

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The impact of medication on vitamin D status in older individuals

Sohl

Schoor

Jongh

et al. 2012

European Journal of Endocrinology

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Objective: Vitamin D deficiency and polypharmacy are common in the elderly. However, knowledge on the associations between the use of specific medicines and serum 25-hydroxyvitamin D (25(OH)D) is limited. The aim of this study was to (better) define the associations between the use of specific medicines and serum 25(OH)D. Methods: Two different cohorts (1995/1996 and 2002/2003) from the Longitudinal Aging Study Amsterdam (LASA) were used for cross-sectional analyses. LASA is based on an age and sex-stratified random sample of the Dutch older population. Study participants were aged 65-88 years in the first cohort (nZ1301) and 55-65 years in the second cohort (nZ736). Serum 25(OH)D of users of several groups of medicines were compared with levels of non-users using multiple linear regression analysis. Results: Of all participants, 75.4% (first cohort) and 61.1% (second cohort) were using at least one medicine. In both cohorts, the number of medicines was associated with lower serum 25(OH)D. In the first cohort, after adjustment for confounding, users of any kind of medicine, loop diuretics and inhaled corticosteroids (only men) had respectively 4.4 nmol/l (P!0.01), 4.7 nmol/l (PZ0.04) and 7.3 nmol/l (PZ0.02) lower serum 25(OH)D than non-users. In the second cohort, the use of oral antidiabetics, calcium-channel blockers and angiotensin-converting enzyme inhibitors was associated with respectively 7.4 nmol/l (PZ0.04), 7.7 nmol/l (PZ0.01) and 7.6 nmol/l (P!0.01) lower serum 25(OH)D. Conclusions: These data show that users of several medicines have lower serum 25(OH)D than nonusers. Vitamin D supplementation may be considered in patients with chronic use of medicines.

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Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

The impact of medication on vitamin D status in older individuals

Sohl

Schoor

Jongh

et al. 2012

European Journal of Endocrinology

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“…26 Vitamin D deficiency, defined as levels of 25(OH)D <30 ng/mL, were found in 37 of 64 (58%) of our patients. Thus, the test of vitamin D status was more often abnormal than normal and therefore clinically important on its own merits since 31,32 although not in all studies, 33 and this may contribute in a small way to the cardioprotective effects of statin therapy. 34 In a small drug interaction study, vitamin D supplementation lowered LDL cholesterol despite lowering blood levels of the statin.…”

Section: Discussionmentioning

confidence: 99%

The role of vitamin D and SLCO1B1 gene polymorphism in statin-associated myalgias

Linde

Peng

Desai

et al. 2010

Dermato-Endocrinology

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“…It has been suggested that the striking benefit achieved with statin treatment in patients with a wide range of cholesterol concentrations cannot be attributed to their cholesterol-lowering effect alone, but rather to additional pleiotropic effects. One of these pleiotropic effects may be mediated in part by an effect on 25OHD metabolism (14 ), and there is some evidence that statins can improve 25OHD concentrations in patients with familial hypercholesterolemia and ischemic heart disease (15)(16)(17)(18).…”

Section: Methodsmentioning

confidence: 99%