Giovanni Luca Beretta, Valentina Benedetti, Giacomo Cossa, Yehuda G.A. Assaraf, Eran Bram, Laura Gatti, Elisabetta Corna, Nives Carenini, Donato Colangelo, Stephen B. Howell, Franco Zunino, Paola Perego
ABSTRACTPt compounds still represent the mainstay of the treatment of ovarian carcinoma. The aim of the present study was to investigate the molecular bases of resistance to Pt drugs using an oxaliplatin-resistant ovarian carcinoma cell model IGROV-1/OHP. These cells exhibited high levels of resistance to oxaliplatin, cross-resistance to cisplatin and topotecan and displayed a
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