Increased level of resistin predicts development of atrial fibrillation

Özcan, Kazım Serhan; Güngör, Barış; Altay, Servet; Osmonov, Damirbek; Ekmekçi, Ahmet; Özpamuk, Fatma; Kemaloglu, Tugba; Yildirim, Aydın; Tayyareci, Gülşah; Erdinler, İzzet

doi:10.1016/j.jjcc.2013.10.008

Cited by 26 publications

(21 citation statements)

References 40 publications

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“…Similarly, in the present study we found that CRP level was higher in AF group than in controls and CRP level was associated with AF. Moreover, we observed an elevated trend of CRP level in permanent AF patients, consistent with previous study [31]. Although CRP is a marker of AF, in the present study we revealed that elevated serum FGF-21 level remained significantly associated with AF, even after the adjustment for CRP, suggesting that serum FGF-21 may be another biomarker of AF.…”

Section: Discussionsupporting

confidence: 92%

Serum fibroblast growth factor 21 levels are increased in atrial fibrillation patients

et al. 2015

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Section: Discussionsupporting

confidence: 92%

Serum fibroblast growth factor 21 levels are increased in atrial fibrillation patients

et al. 2015

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“…Although inflammation is thought to contribute to incident AF, and a small study from Turkey reporting that increased resistin was related to paroxysmal and persistent AF, although not permanent AF 36 , we did not see an independent association of resistin with AF in this cohort during the follow-up period. Our ability to fully investigate AF as an outcome, however, was limited in that AF is not a fully adjudicated outcome in MESA but a self-reported or ICD-9 based event from inpatient records.…”

Section: Discussioncontrasting

confidence: 89%

The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis

Muse¹,

Feldman²,

Blaha³

et al. 2015

Atherosclerosis

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Objective To describe the relationship between circulating resistin levels and cardiovascular diseases (CVD) and all-cause death in a multi-ethnic cohort. Methods and Results We studied 1,913 participants from the Multi-Ethnic Study of Atherosclerosis with measurements of plasma resistin levels. Absolute proportions experiencing new-onset atrial fibrillation (AF), atherosclerotic CVD (myocardial infarction, angina, resuscitated cardiac arrest, stroke), heart failure (HF), and all-cause death were calculated for each quartile of resistin. We used adjusted Cox proportional regression modeling resistin as a continuous variable per standard deviation of log-transformed resistin and secondarily as a categorical variable using resistin quartiles. Results were stratified by sex and race/ethnicity. The mean age of the population was 64.5 ± 10 years with half being female and a median resistin concentration of 15.1 ng/mL (11.9–19.1). Mean follow-up time was 7.2 ± 1.8 years. There was a graded increase in the occurrence of all outcomes across increasing quartiles of resistin. Modeled as a continuous variable, after adjustment for anthropomorphic measures, traditional risk factors, markers of inflammation, and other adipokines, significant associations were noted for HF (HR 1.4, CI 1.0–2.0), hard and all CVD (HR 1.3, 1.1–1.7 and 1.3, 1.1–1.6, respectively), and CHD (HR 1.31, 1.0–1.6), but not for AF or death. Significant interaction terms were noted between resistin and race, with Hispanic race/ethnicity showing the strongest relationship between resistin and outcomes. Conclusions In an ethnically diverse population without known CVD at baseline, there was a strong, independent association between higher resistin levels and incident CVD, CHD and HF.

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“…CRP was shown to attenuate this relationship. Since then, an additional case–control study of 100 patients with AF demonstrated that patients with paroxysmal and permanent AF had higher serum resistin levels than matched controls 21. Most recently, however, the association between resistin and AF was demonstrated to be less robust in a study conducted by Muse et al 22.…”

Section: Discussionmentioning

confidence: 99%

The associations of leptin, adiponectin and resistin with incident atrial fibrillation in women

Ermakov

Azarbal

Stefanick

et al. 2016

Heart

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Increased level of resistin predicts development of atrial fibrillation

Abstract: The elevated levels of plasma resistin were related to paroxysmal AF group and persistent AF group, but not to permanent AF group.

Cited by 26 publications

References 40 publications

Serum fibroblast growth factor 21 levels are increased in atrial fibrillation patients

Serum fibroblast growth factor 21 levels are increased in atrial fibrillation patients

The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis

The associations of leptin, adiponectin and resistin with incident atrial fibrillation in women

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