Increased level of advanced oxidation protein products in patients with coronary artery disease

Kaneda, Hideaki; Taguchi, Junichi; Ogasawara, Kunio; Aizawa, Tadanori; Ohno, Minoru

doi:10.1016/s0021-9150(01)00706-7

Cited by 162 publications

(110 citation statements)

References 15 publications

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“…Of particular clinical importance is the finding that AOPPs are highly correlated with carotid intima media thickness in end-stage renal disease 31 and in peritoneal dialysis patients 32,33 . Moreover, AOPP elevation has been reported as an independent risk factor for coronary artery disease in nonuremic patients 34 .…”

Section: Discussionmentioning

confidence: 99%

In vivo oxidized low-density lipoprotein (ox-LDL) aopp and tas after kidney transplantation: a prospective, randomized one year study comparing cyclosporine a and tacrolimus based regiments

Zadrazil¹,

Horák²,

Štrebl³

et al. 2012

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims.Restoration of renal function after kidney transplantation (KT) is expected to improve oxidative stress (OS). However, little is known about the influence of calcineurin inhibitors on oxidized low-density lipoproteins (ox-LDL) after KT. The aim of this study was to evaluate ox-LDLs and related markers of OS, advanced oxidation protein products (AOPP) and total antioxidant status (TAS) in patients after KT on either cyclosporin A (CyA) or tacrolimus (Tac) treatment.Methods. This was a prospective, randomized, single-center 12 month study evaluating time-dependent changes in biomarkers of OS before and after KT. Twenty nine patients (mean age 54.4 ± 11.1; 55% male and 45% female) were treated with CyA (Group A) and twenty four patients (mean age 52.9 ± 9.9; 75% male and 25% female) were treated with Tac (Group B). The ox-LDL, AOPP, TAS, lipid metabolism parameters, creatinine and glomerular filtration were assessed on day 1 before KT and on days 1 and 7, and in months 1, 3, 6 and 12 after KT. Results. Over the 12 months, the ox-LDL for group A changed from 69.2±32.9 to 65.1±17.1 U/L (P=0.665), while AOPP significantly decreased from 233.0±159.6 to 156.5±90.1 μmol/L (P=0.025) and TAS from 1.87±0.31 to 1.68±0.20 mmol/L (P=0.030). For group B the ox-LDL changed from 62.9±29.7 to ± 61.4±14.6 U/L (P=0.168) and TAS from 1.87±0.51 to 1.68±0.20 mmol/L (P=0.168), while AOPP significantly decreased from 180.5±90.0 to 123.9±37.7 μmol/L (P=0.019). Conclusion. AOPP is more sensitive than ox-LDL for assessing OS after KT. TAS values appear to be insufficiently sensitive for monitoring OS in patients after KT.

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Section: Discussionmentioning

confidence: 99%

In vivo oxidized low-density lipoprotein (ox-LDL) aopp and tas after kidney transplantation: a prospective, randomized one year study comparing cyclosporine a and tacrolimus based regiments

Zadrazil¹,

Horák²,

Štrebl³

et al. 2012

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Increasing evidence indicates that AOPPs, as a novel marker of oxidative stress, are involved in various diseases, such as renal failure (5), diabetes mellitus (9), coronary artery disease (12) and osteoporosis (14), and have various biological activities. The data presented in this study demonstrate that AOPPs inhibit the proliferation and osteogenic differentiation of MSCs.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated levels of AOPPs are detected in many types of diseases, including osteoporosis (9)(10)(11)(12)(13)(14). Certain studies have demonstrated that oxidative stress leads to increased levels of AOPPs in osteoblastic MC3T3-E1 cells (15,16); AOPPs have been shown to inhibit the proliferation and differentiation of rat osteoblastic cells through NF-κB (17); these data suggest that AOPPs are associated with the progression of osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Effect of advanced oxidation protein products on the proliferation and osteogenic differentiation of rat mesenchymal stem cells

Sun

Yang

et al. 2013

International Journal of Molecular Medicine

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Abstract. Advanced oxidation protein products (AOPPs) as a novel marker of oxidative stress, are involved in a variety of diseases, including osteoporosis. Although a number of studies have shown the possible functions of AOPPs in biological processes, little is known about the role of AOPPs in the pathogenesis of osteoporosis. In this study, we aimed to investigate the effect of AOPPs on the proliferation and osteogenic differentiation of rat mesenchymal stem cells (MSCs). MSCs, isolated from bone marrow, were cultured in the absence or presence of AOPPs (50, 100, 200 and 400 mg/ml). MTT assay was used to determine the proliferative ability of the cells. Alkaline phosphatase (ALP) activity, the mRNA expression of ALP and collagen I and bone nodule formation were detected to assess osteogenic differentiation. Reactive oxygen species (ROS) generation was analyzed with the probe 2' ,7'-dichlorodihydrofluorescein diacetate (DCFH-DA). The expression of receptor of advanced glycation end-products (RAGE) at the mRNA and protein level was detected by real-time PCR and western blot analysis, respectively. Compared with the control group, AOPPs inhibited MSC proliferation in a dose-and timedependent manner. Moreover, AOPPs induced a significant reduction in ALP activity, as well as a decrease in ALP and collagen I mRNA levels in the MSCs; bone nodule formation was also inhibited. Furthermore, AOPPs increased ROS generation in the MSCs, and upregulated the expression of RAGE at the mRNA and protein level. These results suggest that AOPPs inhibit the proliferation and osteogenic differentiation of MSCs, possibly through the AOPPs-RAGE-ROS pathway; this may be an important mechanism in the development of osteoporosis.

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“…High serum AOPP levels are observed in coronary artery diseases, suggesting that an accumulation of AOPPs may be a relevant marker of the atherosclerotic process. 7,32 In clinical studies, increased AOPP levels are highly correlated with the carotid intima-media thickness and may increase the prevalence of cardiovascular events. 32 In this study, the AOPP concentration was positively correlated with LDL (R 2 = 0.08, P = 0.05) in obese women, which suggests that proatherogenic changes of the lipid profile are linked to increased oxidative stress.…”

Section: Tablementioning

confidence: 99%

“…7,32 In clinical studies, increased AOPP levels are highly correlated with the carotid intima-media thickness and may increase the prevalence of cardiovascular events. 32 In this study, the AOPP concentration was positively correlated with LDL (R 2 = 0.08, P = 0.05) in obese women, which suggests that proatherogenic changes of the lipid profile are linked to increased oxidative stress. A similar positive correlation between the AOPP level and atherogenic lipid shifts has been observed in dyslipidemic patients with renal disease.…”

Section: Tablementioning

confidence: 99%

Nutritional habits and oxidative stress in postmenopausal age

Grygiel-Górniak¹,

Justyna²,

Szczepanik³

et al. 2014

Polish Archives of Internal Medicine

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Increased level of advanced oxidation protein products in patients with coronary artery disease

Cited by 162 publications

References 15 publications

In vivo oxidized low-density lipoprotein (ox-LDL) aopp and tas after kidney transplantation: a prospective, randomized one year study comparing cyclosporine a and tacrolimus based regiments

In vivo oxidized low-density lipoprotein (ox-LDL) aopp and tas after kidney transplantation: a prospective, randomized one year study comparing cyclosporine a and tacrolimus based regiments

Effect of advanced oxidation protein products on the proliferation and osteogenic differentiation of rat mesenchymal stem cells

Nutritional habits and oxidative stress in postmenopausal age

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