Increased left ventricular mass in obese adolescents*1

Friberg, Peter; Allansdotter-Johnsson, Ase; Ambring, Anneli; Ahl, Ragnhild; Arheden, Håkan; Framme, Jenny Lingman; Johansson, Anna-Karin; Holmgren, Daniel; Wåhlander, Håkan; Mårild, Staffan

doi:10.1016/j.ehj.2004.03.018

Cited by 61 publications

(52 citation statements)

References 27 publications

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“…20 Obesity has been found to be associated with a greater increase of left ventricular muscle mass in women than men, especially in the presence of hypertension. 5,6,21 In the Framingham Heart Study, 22 after adjusting for BMI and other risk factors, glucose intolerance was observed to be related to the left ventricular mass more strongly in women than in men, suggesting that the association between obesity and the left ventricular mass was related to the presence of insulin resistance in women. Statistical interactions between increasing voltage and BMI group or gender on the risk of mortality were not significant, thus formally this study has not proven any difference in the prognostic effect of LVH between women and men or between lean and overweight subjects.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular hypertrophy by Sokolow-Lyon voltage criterion predicts mortality in overweight hypertensive subjects

et al. 2008

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In view of the low sensitivity of Sokolow-Lyon voltage criteria in the assessment of electrocardiographic left ventricular hypertrophy (ECG LVH) in overweight subjects, we determined its clinical utility in 1840 lean and 3555 overweight subjects with hypertension. They were followed prospectively over an average of 11 years by the Department of Health and Social Security Hypertension Care Computer Project. LVH was determined at baseline using the Sokolow-Lyon criterion that is, the amplitude voltage SV1 þ (max RV5 or RV6) X3.5 mV. Overweight status was defined as body mass index (BMI) X25 kg m À2 . Prevalence of ECG LVH was 16% in lean and 12% in overweight women, 35 and 20% in lean and overweight men. For each 0.1 mV increase in ECG voltage as a continuous variable, the age and sex adjusted risk of stroke, coronary heart disease and cardiovascular disease (CVD) mortality increased significantly by 3.0, 1.5 and 1.8% in overweight subjects and by 2.8, 1.8 and 2.4% in lean subjects. After additional adjustments for smoking, blood glucose and serum cholesterol concentration in a subgroup of 654 lean and 1281 overweight subjects with complete information on these variables, an increasing voltage still significantly predicted stroke and CVD mortality in overweight subjects. The excess high risk of dying was evident especially in women with LVH in the highest BMI quartiles. When ECG detects LVH in overweight subjects, it is a good predictor of mortality despite the lower sensitivity in this group.

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Section: Discussionmentioning

confidence: 99%

Left ventricular hypertrophy by Sokolow-Lyon voltage criterion predicts mortality in overweight hypertensive subjects

et al. 2008

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“…Ventricular tachycardia was also significantly more common in patients with perfusion defects (14% vs. 4%, p<0.02) (31,32).…”

Section: Pathophysiology Of Left Ventricular Hypertrophymentioning

confidence: 95%

“…Impaired coronary flow in hypertensive LVH has high prognostic significance for the development of malignant arrhythmias and sudden death (30,31).…”

Section: Pathophysiology Of Left Ventricular Hypertrophymentioning

confidence: 99%

“…LVH adjusted for body weigh was 16% greater in obese compared to lean adolescents. Obese subjects have higher resting systolic blood pressure, higher fasting trigliceride and insulin levels, HDL-cholesterol levels is lower in the obese compared with the lean patients (31). However, the most important factors for the development of LVH are hemodynamic factors such as chronic pressure load, volume overload, arterial structure, contractility, and blood viscosity and nonhemodynamic presented by stimulation of the sympathetic nervous system, activation of the renin-angiotensin-aldosterone system, and genetic predisposition.…”

Section: Pathophysiology Of Left Ventricular Hypertrophymentioning

confidence: 99%

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How to estimate left ventricular hypertrophy in hypertensive patients

Lović¹,

Erdine²,

Çatakoğlu³

2014

Anadolu Kardiyol Derg

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Left ventricular hypertrophy (LVH) is a structural remodeling of the heart developing as a response to volume and/or pressure overload. Previous studies have shown that hypertension is not an independent factor in the development of LVH and occurrence does not depend on the length and severity of hypertension, but the role played by other comorbidities such as triglycerides, age, gender, genetics, insulin resistance, obesity, physical inactivity, increased salt intake and chronic stress. LVH develops through three phases: adaptive, compensatory, and pathological phase. Contractile dysfunction is reversible in the first two phases and irreversible in the third. According to the Framingham study, LVH develops in 15-20% of patients with mild arterial hypertension, and in 50% of patients with severe hypertension. The pathophysiology of LVH includes hypertrophy of cardiomyocytes, interstitial and perivascular fibrosis, coronary microangiopathy and macroangiopathy. Individuals with LVH have 2-4 times higher risk of having adverse CV events compared to patients without LVH. (Anadolu Kardiyol Derg 2014; 14: 389-95)

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“…[2,3] Several authors have demonstrated that obesity has resulted in increased left ventricular mass (LVM). [4][5][6] As a consequence cardiomyopathy of obese individuals often develops initially with diastolic dysfunction and possibly later in the course with worsening left ventricular systolic function. [7] A strong association between obesity and heart failure has also been described by the Framingham Heart Study.…”

Section: Introductionmentioning

confidence: 99%

Effects of Weight Loss on Pericardial Fat and Left Ventricular Mass Assessed with Cardiac Magnetic Resonance Imaging in Morbid Obesity

Schneiter¹,

Warrier²,

Lefkovits³

et al. 2011

IJCM

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Increased left ventricular mass in obese adolescents*1

Abstract: Obese adolescents had a higher LVM than age-matched lean subjects, which correlated mainly with body mass index and systolic blood pressure. These findings add to the established cardiovascular risk profile of obese adolescents.

Cited by 61 publications

References 27 publications

Left ventricular hypertrophy by Sokolow-Lyon voltage criterion predicts mortality in overweight hypertensive subjects

Left ventricular hypertrophy by Sokolow-Lyon voltage criterion predicts mortality in overweight hypertensive subjects

How to estimate left ventricular hypertrophy in hypertensive patients

Effects of Weight Loss on Pericardial Fat and Left Ventricular Mass Assessed with Cardiac Magnetic Resonance Imaging in Morbid Obesity

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