Increased Left Ventricular Mass as a Predictor of Sudden Cardiac Death

Stevens, Steven; Reinier, Kyndaron; Chugh, Sumeet S.

doi:10.1161/circep.112.974931

Cited by 85 publications

(57 citation statements)

References 67 publications

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Section: Discussionmentioning

confidence: 98%

“…In the Framingham Study, for every 50 g increase in LVM, CVD increased by 1.49-and 1.57-fold for men and women, respectively, with higher relative risks for cardiovascular death of 1.73 and 2.12, respectively [14]. In our studies, although the higher LVMI noted in the RA patients with high-ACPA levels fell within the normal range, a progressive increase in LVM is a heart failure precursor in the general population, and strong sudden cardiac death predictor, even in subsets with normal ejection fraction [13,14]. A recent meta-analysis of cross-sectional studies in RA patients without clinical heart failure revealed no consensus on LVMI differences between RA and controls, as higher LVMIs, lower LVMIs and no difference in LVMI have all been reported [10,15].…”

Section: Discussionmentioning

confidence: 98%

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Association of anti-citrullinated protein or peptide antibodies with left ventricular structure and function in rheumatoid arthritis

et al. 2016

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Objective. High levels of ACPAs in RA are associated with more severe arthritis and worse prognosis. However, the role of ACPAs in mediating the increased risk of heart failure in RA remains undefined. We examined whether specific ACPAs were associated with subclinical left ventricular (LV) phenotypes that presage heart failure.Methods. Sera from RA patients without clinical cardiovascular disease were assayed for specific ACPAs using a custom Bio-Plex bead assay, and their cross-sectional associations with cardiac magnetic resonance-derived LV measures were evaluated. High ACPA level was defined as 5 75th percentile. Findings were assessed in a second independent RA cohort with an expanded panel of ACPAs and LV measures assessed by 3D-echocardiography.Results. In cohort 1 (n = 76), higher levels of anti-citrullinated fibrinogen 41 60 and anti-citrullinated vimentin antibodies were associated with a 10 and 6% higher adjusted mean LV mass index (LVMI), respectively, compared with lower antibody levels (P < 0.05). In contrast, higher levels of anticitrullinated biglycan 247 266 were associated with a 13% lower adjusted mean LVMI compared with lower levels (P < 0.001). In cohort 2 (n = 74), the association between ACPAs targeting citrullinated fibrinogen and citrullinated vimentin peptides or protein and LVMI was confirmed: higher anticitrullinated fibrinogen 556 575 and anti-citrullinated vimentin 58 77 antibody levels were associated with a higher adjusted mean LVMI (19 and 15%, respectively; P < 0.05), but no association with biglycan was found.Conclusion. Higher levels of antibodies targeting citrullinated fibrinogen and vimentin peptides or protein were associated with a higher mean LVMI in both RA cohorts, potentially implicating autoimmune targeting of citrullinated proteins in myocardial remodelling in RA.Key words: anti-citrullinated peptide antibody (ACPA), RA, ventricular mass, CVD Rheumatology key messages. Higher levels of ACPAs targeting citrullinated fibrinogen and citrullinated vimentin peptides or protein were associated with higher left ventricular mass index. . Seroreactivity towards citrullinated proteins may play a role in myocardial remodelling in RA.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Association of anti-citrullinated protein or peptide antibodies with left ventricular structure and function in rheumatoid arthritis

et al. 2016

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“…An increase in LV mass leads to myocardial remodelling and fibrosis, which predispose patients to re-entrant arrhythmias. 40 Studies have demonstrated that a LV-wall thickness ≥30 mm is an independent risk factor for SCD, with a 20 % increase in the relative risk of death at 10 years compared to the general HCM population. 41 Based on these studies, the guidelines recommend a LV-wall diameter ≥30 mm be considered an established risk marker.…”

Section: Maximal Left Ventricular-wall Thicknessmentioning

confidence: 99%

ICD Therapy for Primary Prevention in Hypertrophic Cardiomyopathy

Trivedi

Knight

2016

Arrhythmia &Amp; Electrophysiology Review

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HCM is a heterogeneous disease that is classically transmitted in an autosomal dominant fashion. HCM often arises from mutations in genes responsible for the formation of cardiac sarcomeres.Sarcomeric mutations, initially discovered in the 1980s, are found in up to 70 % of patients with a family history of HCM.11 The most common mutations are in the myosin heavy chain (MYH7 gene) and myosin binding protein C (MYBPC3 gene). 12 There is marked heterogeneity in penetrance, however, and a poor understanding of how the different genotypes manifest as HCM phenotypes. Currently, there is minimal evidence to support the use of genetic testing to identify patients who are at high risk of SCD. Small studies have found that patients with a more malignant inheritance of their mutations (i.e. homozygous mutations) as well as the presence of a MYH7 gene mutation have AbstractHypertrophic cardiomyopathy (HCM) is a common and heterogeneous disorder that increases an individual's risk of sudden cardiac death (SCD). This review article discusses the relevant factors that are involved in the challenge of preventing SCD in patients with HCM.The epidemiology of SCD in patients is reviewed as well as the structural and genetic basis behind ventricular arrhythmias in HCM. The primary prevention of SCD with implantable cardioverter-defibrillator (ICD) therapy is the cornerstone of modern treatment for individuals at high risk of SCD. The focus here is on the current and emerging predictors of SCD as well as risk stratification recommendations from both North American and European guidelines. Issues related to ICD implantation, such as programming, complications and inappropriate therapies, are discussed. The emerging role of the fully subcutaneous ICD and the data regarding its implantation are reviewed. KeywordsHypertrophic cardiomyopathy, sudden cardiac death, implantable cardioverter defibrillator, subcutaneous implantable cardioverter-defibrillator Disclosure: Dr Trivedi has no conflicts of interest to declare. Dr Knight has been a consultant to manufacturers of implantable defibrillators and participated in clinical trials sponsored

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“…Laporan The Framingham Heart Study dinyatakan bahwa massa ventrikel kiri berhubungan erat dengan morbiditas serta mortalitas kardiovaskular. 8 Hipertrofi konsentrik sangat berhubungan dengan beban hemodinamik dan abnormalitas struktural yang lebih berat. 6 Sebuah artikel yang ditulis oleh Muiesan dkk.…”

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Indeks Massa Ventrikel Kiri dengan Disfungsi Diastole pada Pasien Konsentrik Penyakit Jantung Hipertensi

Achmad

Martanto

Aprami

et al. 2017

GMHC

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AbstrakHipertrofi ventrikel kiri ditunjukkan secara objektif dengan peningkatan indeks massa ventrikel kiri (IMVK). Peningkatan massa ventrikel kiri dan dilatasi jantung ruang adalah parameter untuk penyakit jantung hipertensi (PJH). Remodeling jantung ini mengubah fungsi jantung yang mengakibatkan disfungsi diastolik. Penelitian ini bertujuan menemukan korelasi antara IMVK dan disfungsi diastolik pada pasien PJH konsentrik. Terdapat 49 pasien PJH konsentrik. Dari 49 pasien, 43 pasien dilibatkan, 15 laki-laki (35%) dan 28 perempuan (65%) memenuhi kriteria inklusi. Penelitian dilakukan di Cardiac Centre RSUP Dr. Hasan Sadikin Bandung periode 1 Oktober 2014-15 Februari 2015. Pemeriksaan tinggi dan berat badan menggunakan alat SMIC ZT 120. Pemeriksaan ekokardiografi standar dilakukan dan fungsi diastolik dinilai dengan pemeriksaan E/e' menggunakan mesin ekokardiografi Vivid 7. Usia rata-rata subjek adalah 56,56 tahun dan indeks massa tubuh rata-rata adalah 25,96 kg/m 2 . Tekanan darah sistole rata-rata 145,51 (SD 21,969) mmHg dan diastole rata-rata 85,13 (SD 10,227) mmHg. Frekuensi denyut jantung rata-rata 74,07 kali/menit. Fraksi ejeksi rata-rata 73,02. Obat yang secara teratur diminum oleh subjek angiotensin-converting enzyme inhibitor pada 17 orang (40%), calcium channel blocker 19 orang (44%), betablocker 15 orang (35%), angiotensin II reseptor blocker 9 orang (21%), dan diuretik 4 orang (9%). Nilai IMVK rata-rata 130,36 (SD 21,077) g/m 2 . Nilai E/e' rata-rata 10,56 (SD 2,761). Hasil penelitian menunjukkan tidak ada hubungan yang signifikan antara IMVK dan derajat disfungsi diastolik (p=0,73). Data IMVK dan derajat tingkat disfungsi diastolik terdistribusi normal. Simpulan, tidak terdapat hubungan antara IMVK dan disfungsi diastolik pada pasien PJH jenis konsentrik.Kata kunci: Disfungsi diastolik, hipertensi, hipertrofi ventrikel kiri, indeks massa ventrikel kiri, penyakit jantung hipertensi Left Ventricular Mass Index with Diastolic Dysfunction in Hypertensive Heart Disease Patients AbstractLeft ventricular hypertrophy was shown with increased left ventricular mass index (LVMI). Increased left ventricular mass and cardiac chamber dilatation are parameters for hypertensive heart disease (HHD). This cardiac remodeling causes changes in heart function resulting in diastolic dysfunction. This study aimed to find the correlation between LVMI and diastolic dysfunction in patients with concentric HHD. We enrolled 49 patients with concentric HHD in Cardiac Centre RSUP Dr. Hasan Sadikin Bandung during 1 October 2014 to 15 February 2015, whom 43 met the inclusion criteria, 15 males (35%) and 28 females (65%). The subjects of study height and weight measured using SMIC tool ZT 120. The standard echocardiography examination was performed and diastolic function was assessed by examination of the E/e' using echocardiography machine Vivid 7. The average age of the subjects was 56.56 years with body mass index of 25.96 kg/m 2 . The average of systolic blood pressure and diastolic blood pressure were 145.51 (SD 21.969) and 85...

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Increased Left Ventricular Mass as a Predictor of Sudden Cardiac Death

Cited by 85 publications

References 67 publications

Association of anti-citrullinated protein or peptide antibodies with left ventricular structure and function in rheumatoid arthritis

Association of anti-citrullinated protein or peptide antibodies with left ventricular structure and function in rheumatoid arthritis

ICD Therapy for Primary Prevention in Hypertrophic Cardiomyopathy

Indeks Massa Ventrikel Kiri dengan Disfungsi Diastole pada Pasien Konsentrik Penyakit Jantung Hipertensi

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