Increased ischaemia-modified albumin is associated with inflammation in acute rheumatic fever

Karataş, Zehra; Baysal, Tamer; Şap, Fatih; Alp, Hayrullah; Mehmetoğlu, İdris

doi:10.1017/s1047951113000516

Cited by 9 publications

(9 citation statements)

References 35 publications

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“…Karataş et al have found that the IMA levels were higher in the acute period and correlated with acute phase reactants in patients with acute rheumatic fever and that the levels were similar to healthy controls in the chronic period. It was suggested that the IMA levels might be associated with acute inflammation [33]. Among patients with Behcet' s disease, the IMA levels were found to increase in those with active disease and vascular involvement [34].…”

Section: Discussionmentioning

confidence: 99%

The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis

Sertpoyraz¹

2020

North Clin Istanbul

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The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis Orıgınal Article PT&R Cite this article as: Sertpoyraz FM, Colak A, Dikici A, Erdinc Gunduz N, Zeytinli Aksit M. The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis. North Clin Istanb UNCORRECTED PROOF A nkylosing Spondylitis (AS) is a chronic rheumatic disease that is characterized by inflammatory low back pain, is often accompanied by peripheral arthritis, and has a prevalence of 0.9% worldwide [1]. It often affects young men, causing loss of function and deterioration in the quality of life [2]. AS is characterized by the inflammation of the sacroiliac joint, peripheral enthesis, and subchondral bone marrow. The mechanism of pathogenesis has not been fully elucidated; however, several genes including human leukocyte antigen (HLA) B27, chronic inflammation caused by intestinal bacteria, cytokines, and oxidative stress are known to have a role in pathogenesis [3]. In an organism, the rate of formation and elimination of free radicals are at equilibrium, which is called oxidative equilibrium. When the oxidative equilibrium is achieved, free oxygen radicals do not affect the organism; oxidative stress occurs when this balance is uneasy.

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Section: Discussionmentioning

confidence: 99%

The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis

Sertpoyraz¹

2020

North Clin Istanbul

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“…Ischemia‐modified albumin (IMA) is a new biochemical marker. It is associated with ischemia, inflammation, and oxidative stress 6 . Recently, high IMA levels have been determined in various inflammatory dermatological diseases such as psoriasis, alopecia areata, vitiligo, and Behçet's disease 7 .…”

Section: Introductionmentioning

confidence: 99%

Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris

Akyürek

Kurtipek

Kurku

et al. 2020

J of Cosmetic Dermatology

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Background Acne vulgaris is a common skin disease in adolescents known to be associated with oxidative stress. However, the number of studies in which oxidative stress and antioxidants are evaluated together is limited. Aims In this study, we aimed to investigate L‐arginine/nitric oxide (NO) pathway metabolites, ischemia‐modified albumin (IMA), and vitamin A and E levels in patients with acne and its association with disease severity. Patients/Methods Ninety patients with acne and 30 healthy adults were included in the study. The serum levels ofL‐arjinin, L‐arginine metabolites, IMA, and vitamins A and E measured in the patient and control groups. Results Asymmetric dimethylarginine (ADMA), LNG‐monomethyl‐L‐arginine (L‐NMMA) and symmetric dimethylarginine (SDMA), and IMA levels were significantly higher in the patients with acne than in the control group (P ˂ .05). The L‐arginine/ADMA ratio and citrulline and vitamin A levels were significantly lower in patients with acne than those of the controls (P ˂ .05). ADMA and IMA plasma levels were increased in parallel with the disease severity (P ˂ .05). L‐arginine/ADMA ratio, L‐arginine, citrulline, and vitamin A plasma levels decreased as the disease became severe (P ˂ .05). Although L‐arginine and vitamin E levels were lower in the patient group compared to the control group, the difference was not statistically significant (P ˃ .05). Conclusion These results suggest that IMA and L‐arginine‐NO pathway associated with ischemia and oxidative stress may play an important role in the pathogenesis and progression of acne vulgaris.

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“…In many diseases with oxidative stress in their etiology and with developed tissue perfusion damage, it has been indicated that IMA has increased and correlated with the disease activity . As far as we know, there is no study in the literature investigating the relation between IBD and IMA.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5] In many diseases with oxidative stress in their etiology and with developed tissue perfusion damage, [6][7][8] it has been indicated that IMA has increased and correlated with the disease activity. 9,10 As far as we know, there is no study in the literature investigating the relation between IBD and IMA. Considering the relation of IMA with oxidative stress and tissue perfusion damage, we think that IMA might be related with the pathogenesis of IBD.…”

Section: Introductionmentioning

confidence: 99%

Is ischemia modified albumin a disease activity marker for inflammatory bowel diseases?

Kaplan¹,

Yüksel²,

Ateş

et al. 2016

J of Gastro and Hepatol

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This is the first study showing that IMA levels in IBD were determined higher in comparison with the control group. Moreover, IMA being a predictor for IBD and being positively correlated with disease activity indexes were determined for the first time in the study. In accordance with these results, it is possible to say that IMA in IBD might be related with the pathogenesis of disease and correlated with the severity of the disease.

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Increased ischaemia-modified albumin is associated with inflammation in acute rheumatic fever

Abstract: The increased level of ischaemia-modified albumin in children with acute rheumatic fever seems to be associated with inflammation. However, further studies are needed to provide stronger evidence.

Cited by 9 publications

References 35 publications

The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis

The relationship of ischemia-modified albumin levels to disease activity scores and HLA-B27 in patients with ankylosing spondylitis

Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris

Is ischemia modified albumin a disease activity marker for inflammatory bowel diseases?

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