Increased iron stores influence glucose metabolism in sickle cell anaemia

Shah, Binal N.; Hassan, Taif; Zhang, Xu; McClain, Donald A.

doi:10.1111/bjh.16596

Cited by 1 publication

(1 citation statement)

References 10 publications

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“…Moreover, it has been reported that in SCD patients intravascular haemolysis contributes to organ damage by increasing oxidative stress due to unbound plasma iron and haeme. 45,46 To our knowledge, the only study that evaluated the relationship between iron stores and glucose metabolism was by Shah et al 47 Their findings suggested that elevated iron stores, in terms of ferritin, were associated with glucose intolerance, even without the diagnosis of diabetes. Past studies showed that diabetes prevalence in SCD was lower than in TM patients and that diabetes approximately affected 2% of SCD patients, 6 similar to 2.9% reported in our study.…”

Section: Discussionmentioning

confidence: 99%

Relationship between pancreatic iron overload, glucose metabolism and cardiac complications in sickle cell disease: An Italian multicentre study

Pistoia

Meloni

Allò

et al. 2022

European J of Haematology

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Objectives: Evidence about the cross-talk between iron, glucose metabolism, and cardiac disease is increasing. We aimed to explore the link of pancreatic iron by Magnetic Resonance Imaging (MRI) with glucose metabolism and cardiac complications (CC) in sickle cell disease (SCD) patients. Methods: We considered 70 SCD patients consecutively enrolled in the Extension-Myocardial Iron Overload in Thalassemia Network. Iron overload was quantified by R2* technique and biventricular function by cine images. Macroscopic myocardial fibrosis was evaluated by late gadolinium enhancement technique. Glucose metabolism was assessed by the oral glucose tolerance test. Results: Patients with an altered glucose metabolism showed a significantly higher pancreas R2* than patients with normal glucose metabolism. Pancreatic siderosis emerged as a risk factor for the development of metabolic alterations (OddsRatio 8.25, 95%confidence intervals 1.51-45.1; p = .015). Global pancreas R2* values were directly correlated with mean serum ferritin levels and liver iron concentration. Global pancreas R2* was not significantly associated with global heart R2* and macroscopic

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Section: Discussionmentioning

confidence: 99%